|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relative risks (odds ratio, OR) of various risk factors for venous thrombophilia, including sex, antithrombin III, protein C (PC), protein S (PS) and plasminogen deficiencies, and C677T homozygous mutation of methylenetetrahydrofolate reductase gene were assessed using age matched (+/-5 years) conditional logistic regression analysis in 116 Chinese venous thrombophilic patients (58 males; 58 females; mean age 47.5+/-17.7 [SD] years) and 125 healthy controls (67 males; 58 females; mean age 45.5+/-15.7 years).
|
10973672 |
2000 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Factor V Leiden G1691A, prothrombin G20210A, MTHFR C677T, and Factor XII C46T mutations are associated with the risk of developing thrombophilia.
|
22521752 |
2012 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thrombophilia workup includes the level of homocysteine and other related parameters such as: vitamin B(12), folic acid, and methylenetetrahydrofolate reductase (MTHFR) C677T genotype.
|
17043779 |
2007 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A postmortem genetic testing for common mutations resulting in thrombophilia should be performed in all individuals who die as a result of thrombosis, regardless of predisposing risk factors, to determine the true prevalence of mutations in these individuals, and to assess the true role of a certain mutation, such as heterozygote MTHFR C677T, in the pathogenesis of thrombosis.
|
25074331 |
2014 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Over 50 unselected women with maternal venous thromboembolism were screened for the prothrombin 20210 G-->A and MTHFR C677T mutations, in addition to screening for other thrombophilias.
|
10759281 |
2000 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While factor V Leiden mutation was more common in women with pregnancy loss (25% vs. 7.6%), factor II G20210A and homozygosity for MTHFR C677T contributed to pregnancy loss only in the presence of other thrombophilia.
|
11821094 |
2002 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors used polymerase chain reaction (PCR) measures for thrombophilia (FVL, PTG, C677T-A1298C methylenetetrahydrofolate reductase [MTHFR], platelet glycoprotein PLA1A2) and hypofibrinolysis (plasminogen activator inhibitor-1 4G4G).
|
18796459 |
2009 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The main inherited thrombophilias (antithrombin deficiency, protein C and S deficiency, FVL, the prothrombin gene variant, and MTHFR C677T homozygotes) have a combined prevalence in Western European populations of 15% to 20%.
|
16962918 |
2006 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study supports the association between MTHFR C677T and patients with early RPL among north Indian Rajputs and strengthens the notion that thrombophilia plays a role in this clinical entity.
|
19839754 |
2009 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether risk factors for placental abruption because of such thrombophilias (such as carriership of factor V Leiden (FVL), prothrombin G20210A gene mutation and homozygous MTHFR C677T) might be used as a predictor for placental abruption.
|
17627684 |
2007 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hypercoagulable state and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with beta-thalassemia major in Kuwait.
|
19940469 |
2010 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and hyperhomocysteinemia were more prevalent than other thrombophilias.
|
17688607 |
2007 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A literature review identified case-control and cohort studies evaluating the relationship between IUGR and the following thrombophilias: homozygous or heterozygous factor V Leiden or prothrombin (PT) G20210A mutations and homozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation.
|
19461414 |
2009 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Factor V Leiden (FVL) G1691A, methylenetetrahydrofolate reductase (MTHFR) C677T, and factor II (FII) G20210A mutations are three important causes of thrombophilia, the condition that might be related to infertility and recurrent spontaneous abortion (RSA).
|
16450127 |
2006 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ancillary testing revealed inherited thrombophilia (Prothrombin 20,210 G > A and MTHFR 677 C > T mutation).
|
29299826 |
2018 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The laboratory tests revealed high D-dimers, and positive IgG anti-cardiolipin and anti-beta2 glycoproteins I antibodies, whereas the genetic profile for thrombophilia revealed heterozygote mutation in MTHFR C677T and A1298C genes.
|
31725629 |
2019 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interpretation These results suggest that the MTHFR C677T-mutant genetically predisposes its carriers to SVT which may contribute to hypercoagulation in pre-existing varicose vein disease.
|
20881312 |
2011 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic analysis for thrombophilia-predisposing mutations factor V Leiden, factor II (prothrombin) G20210A and methylenetetrahydrofolate reductase C677T was performed in all subjects.
|
25977387 |
2016 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single-nucleotide polymorphisms (SNPs) within the genes of factor V (FV) (G1691A; exon 10), prothrombin (FII) (G20210A; 3'untranslated - region) and methylenetetrahydrofolate reductase (MTHFR) (C677T; exon 4) are associated with hypercoagulability, and systematic screening of individuals being at higher risk of thrombosis has been suggested.
|
16305681 |
2005 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?
|
15821810 |
2005 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on the hypothesis that an inherited predilection to hypercoagulability may predispose to HSP or may mark those who develop acute clinical manifestations, we evaluated the possible roles of methylenetetrahydrofolate reductase (MTHFR) gene C677T, factor V (FV) gene G1691A (Leiden), and prothrombin gene G20210A polymorphisms in patients with HSP.
|
16791607 |
2006 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common C677T polymorphism in the methylenetetrahydrofolate reductase gene increases the risk for deep vein thrombosis in patients with predisposition of thrombophilia.
|
10706928 |
2000 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We concluded that, in Taiwanese Chinese, methylenetetrahydrofolate reductase C677T mutation is a common genetic mutation, but T/T homozygote is not a significant risk factor for venous thrombophilia.
|
10680639 |
2000 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The thrombophilia workup included methylenetetrahydrofolate reductase (MTHFR) C677T, antiphospholipid antibodies, protein C, protein S, antithrombin, factor VIII, factor V Leiden, prothrombin mutation G20210A, activated protein C resistance, JAK2 V617F and homocysteine.Ninety-five individuals were tested.
|
26825628 |
2016 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While it is important to consider that milder forms of pyridoxine-responsive classical homocystinuria will be detected only by tHcy, we suggest that routine testing of MTHFR c.677C>T genotype as part of a thrombophilia evaluation in children with incident thromboembolism is not warranted until larger studies have been performed in order to establish or refute a link between MTHFR and adverse outcomes.
|
23866722 |
2013 |