rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thrombophilia workup includes the level of homocysteine and other related parameters such as: vitamin B(12), folic acid, and methylenetetrahydrofolate reductase (MTHFR) C677T genotype.
|
17043779 |
2007 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hypercoagulable state and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with beta-thalassemia major in Kuwait.
|
19940469 |
2010 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A literature review identified case-control and cohort studies evaluating the relationship between IUGR and the following thrombophilias: homozygous or heterozygous factor V Leiden or prothrombin (PT) G20210A mutations and homozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation.
|
19461414 |
2009 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A postmortem genetic testing for common mutations resulting in thrombophilia should be performed in all individuals who die as a result of thrombosis, regardless of predisposing risk factors, to determine the true prevalence of mutations in these individuals, and to assess the true role of a certain mutation, such as heterozygote MTHFR C677T, in the pathogenesis of thrombosis.
|
25074331 |
2014 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
After confirming clinically suspected thromboembolism with suitable imaging methods, pediatric patients should be screened for common gene mutations (factor V G1691A, prothrombin G20210A and MTHFR C677T genotypes), rare genetic deficiencies (protein C, protein S, antithrombin, and plasminogen), and new candidates for genetic thrombophilia causing elevated levels of lipoprotein(a), and homocysteine, and probable genetic risk factors (elevations in fibrinogen, factor IX, and factor VIIIC, and decreases in factor XII).
|
12172465 |
2002 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ancillary testing revealed inherited thrombophilia (Prothrombin 20,210 G > A and MTHFR 677 C > T mutation).
|
29299826 |
2018 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?
|
15821810 |
2005 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on the hypothesis that an inherited predilection to hypercoagulability may predispose to HSP or may mark those who develop acute clinical manifestations, we evaluated the possible roles of methylenetetrahydrofolate reductase (MTHFR) gene C677T, factor V (FV) gene G1691A (Leiden), and prothrombin gene G20210A polymorphisms in patients with HSP.
|
16791607 |
2006 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common C677T polymorphism in the methylenetetrahydrofolate reductase gene increases the risk for deep vein thrombosis in patients with predisposition of thrombophilia.
|
10706928 |
2000 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Factor V Leiden (FVL) G1691A, methylenetetrahydrofolate reductase (MTHFR) C677T, and factor II (FII) G20210A mutations are three important causes of thrombophilia, the condition that might be related to infertility and recurrent spontaneous abortion (RSA).
|
16450127 |
2006 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Factor V Leiden G1691A, prothrombin G20210A, MTHFR C677T, and Factor XII C46T mutations are associated with the risk of developing thrombophilia.
|
22521752 |
2012 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic analysis for thrombophilia-predisposing mutations factor V Leiden, factor II (prothrombin) G20210A and methylenetetrahydrofolate reductase C677T was performed in all subjects.
|
25977387 |
2016 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we carried out an investigation of the most common inherited risk factors for hypercoagulability including the mutation in the factor V gene (factor V Leiden), the transition 20.210G-->A in the prothrombin gene, and also the homozygosity for the 677C-->T transition in the methylenetetrahydrofolate reductase gene (MTHFR).
|
9890294 |
1999 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In order to estimate the frequency of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in Jordanian thrombotic patients, we studied 594 patients admitted to the King Hussein Medical Center for thrombophilia assessment.
|
16093732 |
2005 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interpretation These results suggest that the MTHFR C677T-mutant genetically predisposes its carriers to SVT which may contribute to hypercoagulation in pre-existing varicose vein disease.
|
20881312 |
2011 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and hyperhomocysteinemia were more prevalent than other thrombophilias.
|
17688607 |
2007 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study supports the association between MTHFR C677T and patients with early RPL among north Indian Rajputs and strengthens the notion that thrombophilia plays a role in this clinical entity.
|
19839754 |
2009 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Over 50 unselected women with maternal venous thromboembolism were screened for the prothrombin 20210 G-->A and MTHFR C677T mutations, in addition to screening for other thrombophilias.
|
10759281 |
2000 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Placenta slides of 65 IUFDs with known maternal thrombophilia test results (compound MTHFR C677T and A1298C heterozygosity, n = 10; MTHFR 677TT homozygosity, n = 3; protein S deficiency, n = 0; factor V Leiden mutation, n = 2; prothrombin gene mutation G20210A, n = 1; lupus anticoagulant, n = 2; antiphospholipid syndrome, n = 1; MTHFR C677T heterozygosity, n = 5; MTHFR A1298C heterozygosity, n = 4; and MTHFR 1298CC homozygosity, n = 2) and of 30 livebirths with positive maternal thrombophilia test results (n = 5, 2, 0, 9, 2, 0, 2, 7, 2 and 1, respectively, for those thrombophilias) were microscopically examined for septation, fetal vessel thrombosis, intimal fibrin cushions, avascular villi, haemorrhagic endovasculitis and fibromuscular sclerosis.
|
22173239 |
2012 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single-nucleotide polymorphisms (SNPs) within the genes of factor V (FV) (G1691A; exon 10), prothrombin (FII) (G20210A; 3'untranslated - region) and methylenetetrahydrofolate reductase (MTHFR) (C677T; exon 4) are associated with hypercoagulability, and systematic screening of individuals being at higher risk of thrombosis has been suggested.
|
16305681 |
2005 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The thrombophilia workup included methylenetetrahydrofolate reductase (MTHFR) C677T, antiphospholipid antibodies, protein C, protein S, antithrombin, factor VIII, factor V Leiden, prothrombin mutation G20210A, activated protein C resistance, JAK2 V617F and homocysteine.Ninety-five individuals were tested.
|
26825628 |
2016 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether risk factors for placental abruption because of such thrombophilias (such as carriership of factor V Leiden (FVL), prothrombin G20210A gene mutation and homozygous MTHFR C677T) might be used as a predictor for placental abruption.
|
17627684 |
2007 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors used polymerase chain reaction (PCR) measures for thrombophilia (FVL, PTG, C677T-A1298C methylenetetrahydrofolate reductase [MTHFR], platelet glycoprotein PLA1A2) and hypofibrinolysis (plasminogen activator inhibitor-1 4G4G).
|
18796459 |
2009 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The case with factor VIII of 160% had two other thrombophilias (compound MTHFR C677T-A1298C heterozygosity, resistance to activated protein C), and hypofibrinolytic high Lp(a).
|
16015408 |
2005 |
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The important polymorphisms leading to inherited thrombophilia are Factor V Leiden (FVL), Prothrombin G20210A and MTHFR C677T and A1298C.
|
26135458 |
2016 |