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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment.
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23769397 |
2013 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent association studies have suggested that the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene could play a role in the development of AD.
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18786162 |
2009 |
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rs759834365
|
|
Alzheimer's Disease
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|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the <i>BDNF</i> Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics.
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28468845 |
2017 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of AD in the Chinese population and do not support previous findings that homozygosity for the 66Val allele confers an increased risk for AD.
|
14730194 |
2004 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF.
|
28720165 |
2017 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nevertheless, after adjusting for age and APOE ε4 status, Val66Met was not associated with AD in females (OR, 1.02; 95% CI, 0.94-1.11; P = .57).
|
28984138 |
2018 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although Val66Met polymorphisms were not associated with the cross-sectional diagnoses of MCI or AD, the presence of Met-BDNF allele was associated with a higher risk of disease-progression in patients with MCI (OR=3.0 CI(95%) [1.2-7.8], P=0.02).
|
20491609 |
2010 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and Alzheimer disease, dementia with Lewy bodies, and Pick disease.
|
19812463 |
2010 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis confirmed the gender-related association between BDNF 196A/G polymorphism and AD risk, which may indicate a certain effect of female hormone on progression of the disease.
|
24279351 |
2014 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A sample of AD subjects (N = 341) was genotyped for the BDNF polymorphisms: Val66Met, C270T, and G-712A.
|
19542613 |
2009 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study examined potential association between single nucleotide polymorphisms (SNPs) of the BDNF gene (G11757 C, C270T, G196A, G-712A) and Alzheimer's disease-related depression (AD-D).
|
21677379 |
2011 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease.
|
27494844 |
2016 |
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rs759834365
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Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD).
|
29896439 |
2018 |
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rs759834365
|
|
Alzheimer's Disease
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|
0.100 |
GeneticVariation
|
BEFREE |
We also tested BDNF Val66Met-C270T haplotypes for an interaction with the apolipoprotein E upsilon4 (APOE4) allele in AD.
|
16391475 |
2006 |
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rs759834365
|
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Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The gene variants of the BDNF Val66Met polymorphism were significantly associated with the presence of psychotic symptoms in male, but not in female patients with AD.
|
21044653 |
2011 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
|
27335045 |
2017 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD.
|
16627933 |
2006 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism should be considered as a potential moderator of clinical trial outcomes in current treatment and prevention trials in DIAD and sporadic AD.Ann Neurol 2018;84:424-435.
|
30014553 |
2018 |
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rs759834365
|
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Alzheimer's Disease
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|
0.100 |
GeneticVariation
|
BEFREE |
Among 200 outpatients with dementia and MCI, 146 outpatients with mild AD or A-MCI were recruited and divided into two genotypic groups, valine homozygosity (Val/Val) and methionine (Met) carriers, based on the representative BDNF functional polymorphism Val66Met.
|
22699449 |
2012 |
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rs759834365
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Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
One hundred and sixty-nine outpatients with AD or amnestic mild cognitive impairment (A-MCI) were recruited to the study and divided into three genotypic groups for each representative BDNF functional polymorphism as follows: (i) Val66Met (G196A): G/G (n = 45), G/A (n = 104), and A/A (n = 20); and (ii) C270T: C/C (n = 160), C/T (n = 9), and T/T (n = 0).
|
21951954 |
2011 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese.
|
16054753 |
2005 |
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rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether the BDNF Val66Met gene variant interacts with age to predict brain and cognitive measures in healthy volunteers across the adult lifespan in an intermediate phenotype pattern related to AD by examining (1) cortical thickness, (2) fractional anisotropy of white matter tracts (ie, white matter integrity), and (3) episodic memory performance.
|
21300947 |
2011 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, the plasma BDNF level did not differ significantly among the three BDNF Val66Met genotypic groups or between patients with A-MCI and those with AD.
|
24253237 |
2014 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression.
|
18179845 |
2009 |