|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.
|
20613678 |
2010 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, val66met polymorphism and BDNF serum level between the three groups and genotype did not significantly affect the serum BDNF level or age, Mini-Mental State Examination score in AD and aMCI.
|
23270505 |
2013 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
|
20097294 |
2010 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
After stratification by sex, we found a significant allelic association between Val66Met and AD in women (P = 0.017), but not in men.
|
19504537 |
2010 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To study the role of BDNF 196 G>A and 270 C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196 G>A and 270 C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction.
|
16565926 |
2006 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
SEE ROGAEVA AND SCHMITT-ULMS DOI101093/AWW201 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory decline and hippocampal atrophy in preclinical sporadic Alzheimer's disease.
|
27521573 |
2016 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Understanding the role of brain-derived neurotrophic factor (BDNF) in synaptic plasticity and synaptogenesis, the impact of the BDNF Val66Met polymorphism in Alzheimer's disease-relevant endophenotypes - including episodic memory and hippocampal volume - and the technological progress in measuring synaptic changes in humans all pave the way for a 'synaptic repair' therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis.
|
23674053 |
2013 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To date, there have been several conflicting reports on the correlation between AD or PD and Val66Met or C270T polymorphism in the BDNF promoter region, although no data on this relationship have been published with respect to dementia with Lewy bodies (DLB).
|
16899999 |
2006 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Comparison of 487 Japanese AD subjects with 471 cognitively normal elderly controls showed higher frequencies of the G allele (60.5 vs. 55.5%, p = 0.028) and of both the GG and GA genotypes (85.8 vs. 79.8%, p = 0.025) of the G196A polymorphism in AD subjects than in controls and higher frequency of the T allele of the C270T polymorphism in AD subjects who were negative for apolipotrotein E4 (2.0 vs. 4.4%, p = 0.035) or positive for AD family history (2.8 vs. 7.1%, p = 0.046).
|
15375678 |
2005 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer's disease (AD).
|
24475133 |
2014 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, several reports investigated the association between a single nucleotide polymorphism (Val66Met, rs6265) of the BDNF gene and AD but yielded ambiguous results.
|
17657167 |
2007 |
|
rs759834365
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |