|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Risk alleles for two obesity SNPs were associated with colorectal cancer risk--KCTD15 rs29941 [odds ratio (OR) for C allele = 0.90, 95% confidence interval (CI) 0.83-0.98; p = 0.01] and MC4R rs17782313 (OR for C allele = 1.12, 95% CI 1.02-1.22; p = 0.02).
|
22511254 |
2012 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Impact of the Polymorphism Near <i>MC4R</i> (rs17782313) on Obesity- and Metabolic-Related Traits in Women Participating in an Aerobic Training Program.
|
28828082 |
2017 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The MC4R rs17782313 C allele was more associated with obesity and fat mass deposition in males than in females (P = 0.003 and P = 0.03, respectively) and low physical activity accentuated the effect of the FTO polymorphism on BMI increase and obesity prevalence (P = 0.008 and P = 0.01, respectively).
|
19255736 |
2009 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found correlation for two SNPs--rs11642015 and rs62048402 in the fat mass and obesity-associated protein (FTO) with obesity but no association was detected for rs17782313 located in the MC4R locus in these severely obese individuals.
|
24385306 |
2014 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population, but showed evidence for association with LDL-C (P ~ 0.003) and TC (P ~ 0.001).
|
22350153 |
2012 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data support that the rs9939609 and rs17782313 are strongly associated with obesity and BMI.
|
21063808 |
2011 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the present study, we examined the association between variants in fat mass- and obesity-associated [rs9939609 (A/T)], melanocortin 4 receptor [rs17782313 (C/T), and rs12970134 (A/G)], SLC30A8 [rs13266634 (C/T)], and a member of the potassium voltage-gated channels [rs2237892(C/T)] genes in diabetes patients from Saudi Arabia.
|
25501231 |
2014 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, we could replicate the previously reported association between rs17782313 and complex obesity.
|
21303735 |
2011 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of 11 studied SNPs, four SNPs and genetic risk score (GRS) based on them were statistically significantly associated with central obesity by WC criteria (FTO rs9939609: OR = 1.29, 95%CI = 1.10-1.50, p = 0.001; MC4R rs17782313: OR = 1.27, 95%CI = 1.12-1.44, p = 1.32×10⁻⁴; GNPDA2 rs10938397: OR = 1.22, 95%CI = 1.09-1.37, p = 4.09×10⁻⁴; BDNF rs6265: OR = 1.20, 95%CI = 1.08-1.34, p = 8.86×10⁻⁴; GRS: OR = 1.25, 95%CI 1.16-1.34, p = 2.58×10⁻⁹) after adjustment for sex, age, pubertal stage, physical activity and family history of obesity.
|
23424664 |
2013 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Therefore, the present study aimed to examine the relationships between FTO rs9939609 and the MC4R rs17782313 with REE, leptin, ghrelin and thyrotropin levels in obe</span>se women.
|
24307561 |
2014 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, BDNF rs6265 and MC4R rs17782313 showed gender-dependent associations with decreased risk of having low HDL-C in males and increased risk of having abdominal obesity in females, respectively.
|
31502573 |
2019 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs17782313 C allele is associated with eating behavior traits that may predispose obese children to increased energy intake and obesity.
|
27730429 |
2017 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India.
|
22421923 |
2012 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels.
|
21372613 |
2011 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation.
|
19153581 |
2009 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity.
|
21347432 |
2011 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m<sup>2</sup>) and tend to maintain a BMI > 35 kg/m<sup>2</sup> that characterize treatment failure.
|
28579220 |
2018 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05).
|
22083549 |
2012 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In case-control studies of obesity defined by BMI, the minor C-allele of rs17782313 was associated with overweight/obesity and obesity (odds ratio [OR] 1.09, P = 0.006 and OR 1.12, P = 0.003, respectively).
|
19073769 |
2009 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Most notably, the association between 5 SNPs (Fas apoptotic inhibitory molecule 2 rs7138803, Niemann-Pick disease, type C1 rs1805081, fat mass- and obesity-associated gene rs6499640, melanocortin 4 receptor gene rs17782313, and brain-derived neurotrophic factor rs6265) and obesity risk was only observed in children who had moderate-to-low physical activity levels or engaged in sedentary behavior, regardless of which risk alleles they carried.
|
21527513 |
2011 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.
|
18682847 |
2008 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The common polymorphism rs17782313 lying 188 kb downstream of the MC4R gene has recently been found to be unequivocally associated with body mass index (BMI) and obesity risk in adults and children.
|
20215774 |
2010 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings indicated that rs17782313, rs543874, rs2241423 and rs11084753 were associated with the risk for children obesity in China, and interaction of genetic variants with diet behaviors on obesity.
|
25637721 |
2015 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity.
|
30896429 |
2019 |
|
rs17782313
|
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we investigated the involvement of FTO rs9939609 and MC4R rs17782313 polymorphisms in the development of obesity.
|
19668254 |
2009 |