|
rs4430796
|
|
Prostate carcinoma
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
|
17603485 |
2007 |
|
rs4430796
|
|
Prostate carcinoma
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
rs7501939
|
|
Prostate carcinoma
|
C |
0.740 |
GeneticVariation
|
GWASCAT |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Notably, rs4430796 was significantly associated with prostate cancer among men diagnosed at an early (<50 years) but not later age (P = 0.006 versus P = 0.118).
|
18701471 |
2008 |
|
rs7501939
|
|
Prostate carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
SNPs rs4430796 and rs7501939, which were in strong linkage disequilibrium (r(2) = 0.68), showed the strongest evidence of prostate cancer association.
|
18701471 |
2008 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recent studies have identified 2 distinct genetic variants along chromosome 17, including allele T of single nucleotide polymorphism rs4430796 on 17q12 and allele G of single nucleotide polymorphism rs1859962 on 17q24, that have been linked to prostate cancer risk.
|
19371897 |
2009 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Specifically, we sought to evaluate for effect modification between DM, a newly discovered prostate cancer susceptibility locus on chromosome 17q12 (single nucleotide polymorphism rs4430796) and prostate cancer features.
|
19627283 |
2009 |
|
rs7501939
|
|
Prostate carcinoma
|
|
0.740 |
GeneticVariation
|
GWASCAT |
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
|
19767753 |
2009 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Three HNF1B SNPS, rs11649743, rs4430796, and rs7501939, were associated with decreased risk of prostate cancer and were also associated, with marginal statistical significance, with increased risk of diabetes.
|
19998368 |
2010 |
|
rs7501939
|
|
Prostate carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Three HNF1B SNPS, rs11649743, rs4430796, and rs7501939, were associated with decreased risk of prostate cancer and were also associated, with marginal statistical significance, with increased risk of diabetes.
|
19998368 |
2010 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These associations remained significant after excluding HNF1B SNP rs4430796 (a known PCa risk factor) from the analysis.
|
20203524 |
2010 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The per-T2D-risk-allele odds ratios (95% confidence intervals) for rs4430796 were 0.79 (0.76, 0.83)] per G allele for prostate cancer (p<10(-15) for both); and 1.03 (0.99, 1.07) for all other cancers.
|
20526366 |
2010 |
|
rs7501939
|
|
Prostate carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Similarly for rs7501939 the per-T2D-risk-allele odds ratios (95% confidence intervals) were 0.80 (0.77, 0.83) per T allele for prostate cancer (p<10(-15) for both); and 1.00 (0.97, 1.04) for all other cancers.
|
20526366 |
2010 |
|
rs7501939
|
|
Prostate carcinoma
|
|
0.740 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
|
20676098 |
2010 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.
|
21499250 |
2011 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
After adjustments for age, the C allele of rs6983561 and the A allele of rs4430796 were significantly more frequent among the SPCa patients than among the controls.
|
21557267 |
2011 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Ten SNPs were significantly related to prostate cancer risk at a genome-wide significance level of P < 5 × 10(-8) with the most significant association with rs4430796 (P = 1.62 × 10(-24)).
|
21576123 |
2011 |
|
rs11649743
|
|
Prostate carcinoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
As expected, rs11649743 was related to prostate cancer risk (P = 3.54 × 10(-8)); however, the association within this second locus was stronger for rs4794758 (P = 4.95 × 10(-10)), which explained all of the risk observed with rs11649743 when both SNPs were included in the same model (P = 0.32 for rs11649743; P = 0.002 for rs4794758).
|
21576123 |
2011 |
|
rs4794758
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
As expected, rs11649743 was related to prostate cancer risk (P = 3.54 × 10(-8)); however, the association within this second locus was stronger for rs4794758 (P = 4.95 × 10(-10)), which explained all of the risk observed with rs11649743 when both SNPs were included in the same model (P = 0.32 for rs11649743; P = 0.002 for rs4794758).
|
21576123 |
2011 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Six markers associated with early-onset prostate cancer [rs2171492 (7q32), rs6983561 (8q24), rs10993994 (10q11), rs4430796 (17q12), rs1799950 (17q21), and rs266849 (19q13)] were genotyped.
|
22144497 |
2012 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Individuals with the rs4430796 TT genotype were at increased CaP risk in the Chinese via a recessive model (odds ratios (OR) = 1.56, 95% CI = 1.04-2.33).
|
22561070 |
2013 |
|
rs757210
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Ten T2D markers near 9 loci (NOTCH2, ADCY5, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, MTNR1B, FTO, and HNF1B) were nominally associated with PCa (P < 0.05); the association for single nucleotide polymorphism rs757210 at the HNF1B locus was significant when multiple comparisons were accounted for (adjusted P = 0.001).
|
23193118 |
2012 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa.
|
23464444 |
2012 |
|
rs4430796
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The polymorphism rs4430796 of the chromosome 17q12 appears to be a biomarker for cancer aggressiveness, increased PSA and tumor volume of PCa.
|
24627192 |
2014 |
|
rs2005705
|
|
Prostate carcinoma
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association scan for variants associated with early-onset prostate cancer.
|
24740154 |
2014 |