|
rs1052133
|
|
Acromegaly
|
|
0.010 |
GeneticVariation
|
BEFREE |
Is there any association between the Ser326Cys polymorphism of the 8-oxoguanine glycosylase 1 (OGG1) gene and risk of colon polyp and abnormal glucose tolerance in acromegaly patients?
|
23368532 |
2013 |
|
rs1052133
|
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, the OGG1-Ser326Cys polymorphism was assessed for association with lung ADC risk using a case-control study of a Japanese population consisting of 1097 cases and 394 controls.
|
16800823 |
2006 |
|
rs1052133
|
|
Adenocarcinoma of lung (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
In this study, polymorphisms in five genes involved in the metabolism of carcinogens or in the repair of damaged DNA in lung cells, NQO1-Pro187Ser, GSTT1-positive/null, GSTM1-positive/null, CYP1A1-Ile462Val, and OGG1-Ser326Cys, were examined for association with lung adenocarcinoma risk in a case-control study of 198 patients and 152 control subjects.
|
12163326 |
2002 |
|
rs1052133
|
|
Adenocarcinoma of lung (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
These results indicate that rs1052133 contributes to the risk of adenocarcinoma of lung.
|
19881468 |
2009 |
|
rs1052133
|
|
Adenocarcinoma of lung (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis indicates that OGG1 Ser326Cys show an increased lung cancer risk in Asians and non-smokers, APEX1 Asp148Glu polymorphism may be associated with decreased lung adenocarcinoma risk, and APEX1 Asp148Glu polymorphism show an increased lung cancer risk in Asians and smokers.
|
23065211 |
2012 |
|
rs1052133
|
|
Adenocarcinoma of lung (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of the OGG1-Ser326Cys polymorphism with lung adenocarcinoma risk.
|
16800823 |
2006 |
|
rs1052133
|
|
Adenocarcinoma of lung (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study supported the first study by Sugimura et al (Cancer Epidemiol Biomarkers Prev, 1999; 8: 669-674), that the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma.
|
12164330 |
2002 |
|
rs1052133
|
|
Adenoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriers of the variant allele OGG1 Ser326Cys polymorphism had a lowered risk of colorectal cancer, OR=0.56 (95% confidence interval 0.33-0.95), while no association were found with risk of adenomas.
|
15946795 |
2005 |
|
rs1052133
|
|
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
|
15946795 |
2005 |
|
rs1052133
|
|
Adult Hepatocellular Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In subgroup analyses by cancer types, we found that the hOGG1 Ser326Cys polymorphism may increase hepatocellular cancer and colorectal cancer risks, but decrease the risk of oral cancer.
|
25323581 |
2015 |
|
rs1052133
|
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
We demonstrated that the c.977C>G polymorphism (rs1052133) in the hOGG1 gene and the c.972G>C polymorphism (rs3219489) in the MUTYH gene, the products of which play important roles in the repair of oxidatively damaged DNA, might be associated with the risk of AMD.
|
23202958 |
2012 |
|
rs1052133
|
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our findings suggest that the c.977C>G-hOGG1 polymorphism may be associated with dry AMD.
|
22469746 |
2012 |
|
rs1052133
|
|
Age-related cataract
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association between the 8-oxoguanine DNA glycosylase gene Ser326Cys polymorphism and age-related cataract: a systematic review and meta-analysis.
|
28631182 |
2018 |
|
rs1052133
|
|
Age-related cataract
|
|
0.020 |
GeneticVariation
|
BEFREE |
Results suggest that the Cys/Cys genotype of the OGG1-Ser326Cys polymorphism may be associated with increased risk of age-related cataract.
|
22306120 |
2012 |
|
rs1052133
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
Regarding the OGG1-rs1052133, the GG (OR = 1.925; 95%CI, 1.181-3.136; p = 0.009) and CG (OR = 1.384; 95%CI, 1.171-1.636; p<0.001) genotypes indicated higher risk of ARC.
|
28253266 |
2017 |
|
rs1052133
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The OGG1 gene Ser326Cys polymorphism was associated with ARC risk.
|
28631182 |
2018 |
|
rs1052133
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The polymorphic variants of XRCC1 c.580C>T XRCC1 c.1196A>G and OGG1 c.977C>G are associated with increased DNA damage in AD.
|
27011006 |
2016 |
|
rs1052133
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
It was concluded that oxidative DNA damage is increased in patients with Alzheimer's disease and OGG1 Ser326Cys polymorphism may be responsible for this increase.
|
31299287 |
2019 |
|
rs1052133
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
We performed a case-control study including 178 patients with sporadic AD (sAD) and 146 matched controls to evaluate the role of the Ser326Cys polymorphism as a risk factor for sAD.
|
17240059 |
2007 |
|
rs1052133
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The aim of the present study was to validate the association of the five AD-associated variants, 8-oxoguanine DNA glycosylase 1 (<i>OGG1</i>) rs1052133, bridging integrator 1 rs744373, sortilin-related receptor 1, rs1133174, presenilin 2 rs8383, and nerve growth factor rs6330, in the Xinjiang Chinese population.
|
30214536 |
2018 |
|
rs1052133
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
No significant association was observed between the variant alleles of hOGG1-Ser326Cys (OR=1.32, 95% CI=0.83-2.11), APE1-Asp148Glu (OR=1.08, 95% CI=0.70-1.68), XRCC1-Arg280His (OR=0.53, 95% CI=0.24-1.14) and XRCC1-Arg399Gln (OR=1.05, 95% CI=0.68-1.63) and AD.
|
18672023 |
2008 |
|
rs1052133
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The purpose of this study was to determine the level of 8-oxo-2'-deoxyguanosine (8-oxo2dG) and expression of three isoforms of 8-oxoguanine glycosylase 1 (OGG1), OGG1-1a, 1b, and 1c, and OGG1 protein and Ser326Cys and Arg46Gln polymorphisms of the OGG1 gene, in peripheral blood lymphocytes of patients with Alzheimer's disease (AD) and healthy controls.
|
19630534 |
2009 |
|
rs1052133
|
|
Amyotrophic Lateral Sclerosis, Sporadic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis.
|
17531381 |
2007 |
|
rs1052133
|
|
Angiomyolipoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Taken together, our findings suggest that Ser(326)Cys variant of OGG1 may confer risk for development of an</span>giomyolipomas by increasing oxidative DNA damage.
|
17932460 |
2008 |
|
rs1052133
|
|
Angiomyolipoma of kidney
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association analysis showed the presence of significant association (p = 0.01) only between the Ser(326)Cys polymorphism of OGG1 and angiomyolipoma.
|
17932460 |
2008 |