|
rs1052133
|
|
Barrett Esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the role of oxidative DNA damage, glutathione (GSH) concentration as oxidative stress parameters and DNA repair capacity, GSTM1, SOD1 Ala16Val and OGG1 Ser326Cys genetic polymorphisms as individual susceptibility parameters in the etiology of BE.
|
20056743 |
2010 |
|
rs1052133
|
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
Consistent with the above findings, we found that the ADPRT V762A was only significantly involved in bladder cancer</span> risk in never smokers and the OGG1 S326C was only significantly involved in ever smokers.
|
17220334 |
2007 |
|
rs1052133
|
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that hOGG1 Ser326Cys polymorphism may contribute to the susceptibility to bladder cancer in a Chinese population.
|
22463382 |
2012 |
|
rs1052133
|
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
Among four DNA repair gene polymorphisms, the OGG1 326 Ser/Cys and XPD 312 Asp/Asn heterozygous genotypes might be recognized as potential genetic markers modifying susceptibility to bladder cancer in Belarus.
|
25089939 |
2014 |
|
rs1052133
|
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the hOGG1 Ser326Cys polymorphism may be a risk factor for bladder cancer without exposure to smoking.
|
22857644 |
2012 |
|
rs1052133
|
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
Overall, no significant association between the hOGG1 Ser326Cys polymorphism and bladder cancer</span> risk was found for Cys/Cys vs Ser/Ser (OR = 1.10, 95%CI = 0.74-1.65), Ser/Cys vs Ser/Ser (OR = 1.07, 95%CI = 0.81-1.42), Cys/Cys + Ser/Cys vs Ser/Ser (OR = 1.08, 95%CI = 0.87-1.33), and Cys/Cys vs Ser/Cys + Ser/Ser (OR = 1.04, 95%CI = 0.65-1.69).
|
23079842 |
2012 |
|
rs1052133
|
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
We undertook a case-control study of 212 urothelial bladder cancer (UBC) cases and 250 controls to investigate the association between OGG1 (C1245G rs1052133), XRCC3 (C18067T, rs861539) and XRCC7 (G6721T, rs7003908) polymorphisms and bladder cancer susceptibility by PCR-RFLP and the ARMS method.
|
19815090 |
2010 |
|
rs1052133
|
|
Bladder Neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
The overall current literature on hOGG1 Ser326Cys polymorphism and the risk of bladder cancer suggests no statistically significant association between the two.
|
22156293 |
2012 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the c.977C>G polymorphism in hOGG1 is associated with an increased risk of breast cancer in Chinese Han women who are younger than 55 years, premenopausal, triple-negative, or p53-positive subgroups.
|
23369609 |
2013 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis.
|
20058067 |
2010 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant associations were observed among rs1130409, rs1052133, rs2072668 and breast cancer risk.
|
29720094 |
2018 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our novel findings therefore suggest that hOGG1 Ser326Cys polymorphism is unlikely to play a modifying role in individual susceptibility to breast cancer among Asian women.
|
12779082 |
2003 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast to the CC and CG genotypes, the GG genotype of rs1052133 located on theOGG1 gene appeared to be a protective factor against developing breast cancer in both Mongoloid and Caucasoid populations.
|
29662639 |
2018 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The hOGG1 SNP rs1052133 (Ser326Cys) minor allele T showed a significant association with breast cancer samples (OR = 1.78, χ2 = 7.86, p = 0.02024).
|
27822728 |
2017 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between having at least one variant allele and breast cancer risk was stronger among moderate alcohol drinkers for Ser(326)Cys [odds ratio (OR), 1.82; 95% confidence interval (95% CI), 1.06-3.10] relative to nondrinkers with the wild-type genotype and among those with higher BMI for 7143A/G (OR, 1.47; 95% CI, 1.10-1.96) and for 11657A/G (OR, 1.41; 95% CI, 1.05-1.88), relative to women with BMI < 25 kg/m(2) and the wild-type genotype.
|
16614128 |
2006 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study suggested that the carrier of Ser326Cys polymorphism of hOGG1, Cys/Cys vs Ser/Ser, are at higher risk for breast cancer, independent of other hormonal and environmental risk factors.
|
28608470 |
2018 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) of OGG1 (Ser326Cys), XRCC1 (Arg399Gln), and APE1 (Asp148Glu and -141T/G) were genotyped and analyzed for their association with breast cancer risk using multivariate logistic regression models.
|
24606430 |
2014 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A population-based cohort study of 470 women diagnosed with primary breast cancer and a median follow up of 52.44 months was conducted to examine the disease-free and overall survival in rs3736729, rs207454 and rs1052133 genetic variants.
|
23443115 |
2012 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, no significant associations between the hOGG1 Ser32</span>6Cys polymorphism and breast cancer risk were found for Cys/Cys versus Ser/Ser (OR = 1.07, 95% CI: 0.94-1.20), Ser/Cys versus Ser/Ser (OR = 0.99, 95% CI: 0.91-1.07), Cys/Cys + Ser/Cys versus Ser/Ser (OR = 1.00, 95% CI = 0.93-1.08), and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.07, 95% CI: 0.97-1.18).
|
20054639 |
2010 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nonetheless, published data were consistent with associations between: (a) the OGG1 S326C variant and increased risk of various types of cancer; (b) the XRCC1 R194W variant and reduced risk of various types of cancer; and (c) the BRCA2 N372H variant and increased risk of breast cancer.
|
12496039 |
2002 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The APEX1 Asp148Glu carrier, in combination with OGG1 rs2072668 and OGG1 Ser326Cys, was strongly associated with an increased risk of BC.
|
24076439 |
2013 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that the OGG1 Ser326Cys polymorphism may be a risk factor for breast cancer in Asians and postmenopausal patients.
|
24893568 |
2014 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping of polymorphisms of XRCC1 (Arg194Trp and Arg399Gln), OGG1 (Ser326Cys and Arg229Gln), ERCC2 Lys751Gln, ERCC4 Ser662Pro, and ERCC5 His1104Asp was performed and used to evaluate breast cancer susceptibility.
|
20183911 |
2010 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Similarly ~14-fold increased risk was associated with Val159Gly (p < 0.01), ~17-fold with Gly221Arg (p < 0.005), and ~18-fold with Ser326Cys (p < 0.004) in breast cancer patients compared with controls, whereas analysis of nonsense mutation showed that ~13-fold (p < 0.01) increased breast cancer risk was associated with Trp375STOP in patients compared to controls.
|
26089588 |
2015 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed a strong association between breast cancer occurrence and the genotypes C/C of the RAD51-135G/C polymorphism, Ser/Ser of the OGG1-Ser326Cys and Lys/Gln of the XPD-Lys751Gln, whereas the genotypes G/C of the RAD51-135G/C and Lys/Lys of the XPD-Lys751Gln exerted a protective effect against breast cancer.
|
18977234 |
2008 |