|
rs3024498
|
|
Helminthiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Allele C of marker rs3024498 was negatively associated with helminth infection or its markers.
|
23273955 |
2013 |
|
rs3024498
|
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The variant of the TNFA gene at rs3093662, the IL12 gene at rs3213094 and rs3212220 and the IL10 gene at rs3024498 did show a strong indication to be of relevance to the immunity to tuberculosis.
|
21463712 |
2011 |
|
rs3024498
|
|
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interestingly, significant differences were detected both in the allele and genotype frequencies of rs3024498 between SLE patients with and without arthritis (P=0.002, P=0.022, respectively).There was significant difference in genotype frequency at rs3024498 between SLE patients with and without malar rash (P=0.040).
|
29199038 |
2018 |
|
rs3024498
|
|
Tick-Borne Encephalitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to estimate a possible association of the IL28B gene rs8103142 and rs12980275 SNPs and IL10 gene rs1800872, rs3021094, and rs3024498 SNPs with predisposition to TBE in a Russian population.
|
27068548 |
2016 |
|
rs3024498
|
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
And, there was significant difference in allele frequency at rs3024498 between SLE patients with and without anti-double-stranded DNA (P=0.032).
|
29199038 |
2018 |
|
rs3024498
|
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interestingly, we have found, majority of the tribal populations have low frequency of VL ('A' of rs3024498); and high frequency of leprosy ('T' of rs1554286), and Behcet's ('A' of rs1518111) associated alleles, whereas these were vice versa in castes.
|
25941808 |
2015 |
|
rs3024498
|
|
Leishmaniasis, Visceral
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interestingly, we have found, majority of the tribal populations have low frequency of VL ('A' of rs3024498); and high frequency of leprosy ('T' of rs1554286), and Behcet's ('A' of rs1518111) associated alleles, whereas these were vice versa in castes.
|
25941808 |
2015 |
|
rs3024496
|
|
Endometriosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant difference was observed in genotypic or allelic frequencies between control and endometriosis groups for rs498679 (TLR4 gene), rs1799964 (TNF-α gene), rs3024496 (IL-10 gene), neither when comparing endometriosis subgroups (I-II versus III-IV).
|
28470452 |
2017 |
|
rs3024496
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations of IL10 haplotypes with prostate cancer were explained by high linkage disequilibrium between two tagSNPs (rs1800890 and rs3024496) and -1082G>A.
|
19267370 |
2009 |
|
rs3024496
|
|
Malignant neoplasm of skin
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the discovery population, genetic variants in the one-carbon metabolism genes phosphatidylethanolamine N-methyltransferase (rs2278952, P for interaction = .004; rs897453, P for interaction = .05) and dihydrofolate reductase (rs1650697, P for interaction = .02), the inflammation gene interleukin 10 (rs3024496, P for interaction =.04), and the skin cancer genes inositol polyphosphate-5-phosphatase (INPP5A; rs1133400, P for interaction = .03) and xeroderma pigmentosum complementation group C (rs2228000, P for interaction = .01) significantly modified the association between arsenic and skin lesions after adjustments for multiple comparisons.
|
25759212 |
2015 |
|
rs3024496
|
|
Infection caused by Helicobacter pylori
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results shown that IL10 single nucleotide polymorphisms rs1800896 (OR = 1.63; 95% CI = 1.11-2.39), rs3024491 (OR = 1.71; 95% CI = 1.14-2.57), rs1878672 (OR = 1.79; 95% CI = 1.19-2.68), and rs3024496 (OR = 1.48; 95% CI = 1.05-2.08) were positively associated with Helicobacter pylori infection.
|
24628819 |
2014 |
|
rs3024496
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations of IL10 haplotypes with prostate cancer were explained by high linkage disequilibrium between two tagSNPs (rs1800890 and rs3024496) and -1082G>A.
|
19267370 |
2009 |
|
rs3024496
|
|
Skin lesion
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the discovery population, genetic variants in the one-carbon metabolism genes phosphatidylethanolamine N-methyltransferase (rs2278952, P for interaction = .004; rs897453, P for interaction = .05) and dihydrofolate reductase (rs1650697, P for interaction = .02), the inflammation gene interleukin 10 (rs3024496, P for interaction =.04), and the skin cancer genes inositol polyphosphate-5-phosphatase (INPP5A; rs1133400, P for interaction = .03) and xeroderma pigmentosum complementation group C (rs2228000, P for interaction = .01) significantly modified the association between arsenic and skin lesions after adjustments for multiple comparisons.
|
25759212 |
2015 |
|
rs1800871
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |
|
rs1800871
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
rs1800871
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Similarly, rs1518111, which showed strong</span> linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026).
|
24269690 |
2014 |
|
rs1800871
|
|
Behcet Syndrome
|
T |
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
rs1800871
|
|
Behcet Syndrome
|
T |
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
rs1800871
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Compared to the controls, an increased frequency of the rs1800871 T allele was observed in BD patients with extraocular findings, including genital ulcers, skin lesions, and a positive pathergy test.
|
26015771 |
2015 |
|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Similarly, rs1518111, which showed strong linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026).
|
24269690 |
2014 |
|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Interestingly, we have found, majority of the tribal populations have low frequency of VL ('A' of rs3024498); and high frequency of leprosy ('T' of rs1554286), and Behcet's ('A' of rs1518111) associated alleles, whereas these were vice versa in castes.
|
25941808 |
2015 |
|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
In IL10, rs1518111 was nominally associated with BD before and after adjustment for population stratification (odds ratio [OR] for T allele 1.20, 95% confidence interval [95% CI] 1.02-1.40, unadjusted P [P(unadj) ] = 2.53 × 10(-2) ; adjusted P [P(adj) ] = 1.43 × 10(-2) ), and rs1554286 demonstrated a trend toward association (P(unadj) = 6.14 × 10(-2) ; P(adj) = 3.21 × 10(-2) ).
|
22378604 |
2012 |
|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
rs1518111
|
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
rs3024493
|
|
Ulcerative Colitis
|
T |
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
|
20228798 |
2010 |