|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history.
|
23880378 |
2013 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.
|
21037213 |
2010 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aims of the present case-control study were to investigate the possible role of BDNF Val66Met, 5-HTTLPR and -1438 G/A polymorphisms in the development of coronary artery disease (CAD) in patients with and without depression.
|
19885623 |
2009 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord.
|
20921572 |
2010 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess the genetic contribution of BDNF Val66Met functional polymorphism to AD-related depression.
|
18179845 |
2009 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study.
|
23481907 |
2013 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression.
|
26756166 |
2016 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms might predict the incidence of depression with ABB.
|
24274373 |
2013 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
|
29331787 |
2018 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety.
|
25618300 |
2015 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression.
|
17959306 |
2007 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
|
17911362 |
2007 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we determined the effects of the BDNF Val66met polymorphism on the five-factor personality dimensions (assessed using the NEO-FFI), trait depression (assessed with the DASS-21) in a cross-sectional cohort of 467 healthy volunteers.
|
18548532 |
2009 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF.
|
29280414 |
2019 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects.
|
14673216 |
2003 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained.
|
17482146 |
2007 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005).
|
17632285 |
2007 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression.
|
27073970 |
2017 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.
|
18263664 |
2008 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequency of the A allele of rs6265 (Val66Met) was significantly higher in AD-D patients than in the healthy controls (p=0.009 after Bonferroni correction).
|
21880305 |
2011 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity.
|
18721847 |
2008 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.
|
22931410 |
2012 |