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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
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BEFREE |
The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression.
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28527683 |
2017 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity.
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23733090 |
2013 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research.
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17700574 |
2007 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
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BEFREE |
The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03).
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24433458 |
2014 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The present findings indicate the gender differences in the effect of Val66Met genotype on the cortisol responses to stress protocol, and extend the evidence for the importance of gender and the role of Val66Met in the modulation of stress reactivity and subsequent depression prevalence.
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28249185 |
2017 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders.
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20515664 |
2010 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness.
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16043130 |
2005 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.
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21996278 |
2012 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
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BEFREE |
The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.
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20220593 |
2010 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the BDNF Val66Met polymorphism is a relevant risk factor for geriatric depression.
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16343697 |
2006 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT.
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29802070 |
2019 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
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27335045 |
2017 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity.
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20346518 |
2010 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression.
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25648279 |
2015 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism may modify the association between stroke and depression.
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17222482 |
2008 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC.
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30904785 |
2019 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The low activity variants of the 5-HTT-linked polymorphic region in the serotonin transporter gene and the Met-allele of a single nucleotide polymorphism (Val66Met) in the gene encoding brain derived neurotrophic factor were independently associated with the presence of stressful life events prior to onset of depression, also when corrected for the effect of age, gender, marital status, personality disorder, neuroticism, and severity of depressive symptoms at the time of interview.
|
19339052 |
2009 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression.
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24745471 |
2014 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
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20515362 |
2010 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase).
|
20163778 |
2010 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects.
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23968401 |
2013 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
Plasma brain-derived neurotrophic factor (BDNF) concentration and the <i>BDNF</i> Val66Met polymorphism in suicide: a prospective study in patients with depressive disorder.
|
31308724 |
2019 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history.
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25347540 |
2014 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.
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25745134 |
2015 |
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rs759834365
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Depressive disorder
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0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression.
|
26462036 |
2015 |