|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met polymorphism of the BDNF gene may be associated with cognitive performance on the WCST in bipolar mood disorder but not in schizophrenia.
|
16472361 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia.
|
26503495 |
2015 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
|
29331787 |
2018 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients.
|
29898578 |
2018 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant association of rs6265 AA + AG × rs1799964 CC + CT with schizophrenia was observed (OR = 1.14, 95%CI: 1.02-1.27; P = .02).
|
29306772 |
2018 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single base pair polymorphism (BDNF Val66Met) was reported to be associated with AD and/or schizophrenia, as well as other psychoses, although some studies failed to replicate these findings.
|
21044653 |
2011 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and cognitive performance in antipsychotic-naïve patients with schizophrenia.
|
22477643 |
2012 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia.
|
18056245 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons.
|
18325670 |
2008 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of the brain-derived neurotrophic factor Val66Met polymorphism with negative symptoms severity, but not cognitive function, in first-episode schizophrenia spectrum disorders.
|
27668551 |
2016 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met genotyping was performed in 27 matched pairs of schizophrenia and comparison subjects.
|
16513879 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia.
|
20430595 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met and cannabis use before illness onset were retrospectively assessed in a sample of 585 patients with schizophrenia and their association with age at onset was evaluated.
|
21305693 |
2011 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF G196A gene rs6265 polymorphism is not associated with the cognitive function but with the clinical symptoms of schizophrenia.
|
23923080 |
2013 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF also contains a functional single-nucleotide polymorphism at codon 66 (Val66Met) of its prodomain and this polymorphism is responsible for schizophrenia susceptibility.
|
16897602 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.
|
19018714 |
2008 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia.
|
23319002 |
2013 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Data from several recent studies have also converged showing that the val66met allele of BDNF, a common single nucleotide polymorphism (SNP), is associated with selective minor deficits in cognitive functioning in subjects with schizophrenia, bipolar illness, and normal controls.
|
17239400 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA methylation profiles were generated for CpG sites proximal to Val66Met, within BDNF promoter I and exon V for prefrontal cortex samples from 25 schizophrenia and 25 control subjects.
|
27712141 |
2017 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia.
|
19714565 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia.
|
20957650 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task.
|
20708907 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies will be required in this area to confirm the effect of the BDNF Val66Met polymorphism in the pathophysiology of schizophrenia and patients' response to antipsychotic drugs, especially in a larger sample size and in different ethnic populations.
|
30312750 |
2018 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, a meta-analysis including the present and previous Asian studies comparing 2059 patients with schizophrenia and 2765 controls also revealed no significant association between the BDNF Val66Met polymorphism and schizophrenia.
|
17267117 |
2007 |