|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment.
|
12951204 |
2003 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val66 met polymorphism.
|
15719396 |
2005 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder.
|
15630410 |
2005 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we investigated whether val66met, a functional and abundant missense polymorphism in the coding region of the BDNF gene, was associated with the volume of the hippocampal formation in 19 patients with first-episode schizophrenia and 25 healthy volunteers.
|
15768049 |
2005 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our investigation indicates that the BDNF gene Val66Met polymorphism is related to the onset age of schizophrenia and the levels of clinical symptoms that remain after long-term antipsychotic treatment.
|
16533563 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met polymorphism of the BDNF gene may be associated with cognitive performance on the WCST in bipolar mood disorder but not in schizophrenia.
|
16472361 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the association between the Val66Met polymorphism of the gene and schizophrenia in 401 Japanese patients with schizophrenia and 569 controls.
|
16854566 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To characterize the neurocognitive and brain morphometric phenotypic correlates of the BDNF Val66Met polymorphism and to test the specificity of the BDNF(Met) variant on cognitive dysfunction in schizophrenia.
|
16818862 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study tested, in a sample of 94 nuclear families, the hypothesis that the BDNF gene Val66Met polymorphism is associated to SZ and its psychopathologic phenotype using a multidimensional symptom approach.
|
16389585 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess whether three BDNF gene polymorphisms (rs988748, C132T and rs6265) could be implicated in vulnerability to schizophrenia, we conducted a case-control association analysis (349 patients and 423 controls) in Japanese subjects.
|
16631352 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met genotyping was performed in 27 matched pairs of schizophrenia and comparison subjects.
|
16513879 |
2006 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study confirms the association of Val66Met to substance-related disorders, eating disorders, and schizophrenia.
|
17217930 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our population-based study and meta-analysis demonstrate that the BDNF C-270T and Val66Met polymorphisms do not play major roles in the susceptibility to schizophrenia in either Caucasian or Asian populations.
|
17289348 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, a meta-analysis including the present and previous Asian studies comparing 2059 patients with schizophrenia and 2765 controls also revealed no significant association between the BDNF Val66Met polymorphism and schizophrenia.
|
17267117 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine, by meta-analysis, if the Val66Met polymorphism of BDNF influences risk for either schizophrenia, bipolar disorder, or both.
|
17417060 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis based on Asian and Caucasian subjects did not give positive result that rs6265 is associated with schizophrenia.
|
17196936 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The overall analysis for investigating the association of the G196A allele G and the risk of developing schizophrenia relative to the allele A, showed significant evidence of heterogeneity (P=0.05, I(2)=58%) between the studies and nonsignificant association [random effects odds ratio 1.08 and 95% confidence interval (0.88-1.32)].
|
17413445 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF also contains a functional single-nucleotide polymorphism at codon 66 (Val66Met) of its prodomain and this polymorphism is responsible for schizophrenia susceptibility.
|
16897602 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Data from several recent studies have also converged showing that the val66met allele of BDNF, a common single nucleotide polymorphism (SNP), is associated with selective minor deficits in cognitive functioning in subjects with schizophrenia, bipolar illness, and normal controls.
|
17239400 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia.
|
18056245 |
2007 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether the Val66Met polymorphism of the BDNF gene affected weight gain after long-term antipsychotic treatment in schizophrenia.
|
17987059 |
2008 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons.
|
18325670 |
2008 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This differential response to fetal hypoxia was specific to schizophrenia and was not explained by other obstetric complications or by the BDNF valine (val) to methionine (met) polymorphism at codon 66 (val66met).
|
18486103 |
2008 |