|
rs1003346
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequently subgroup analysis indicated that both rs2200733 and rs10033464 conferred increased risk for cardioembolic stroke (CE stroke) (for rs2200733, OR 1.38, 95 % CI 1.26-1.51; for rs10033464, OR 1.14, 95 % CI 1.02-1.26), while rs2200733 was marginal associated with non-CE stroke (OR 1.09, 95 % CI 1.02-1.16). our results demonstrated that two SNPs (rs2200733 and rs1003346) on chromosome 4q25 were limited to the stroke of cardioembolic etiology.
|
24065534 |
2013 |
|
rs10033464
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequently subgroup analysis indicated that both rs2200733 and rs1</span>0033464 conferred increased risk for cardioembolic stroke (CE stroke) (for rs2200733, OR 1.38, 95 % CI 1.26-1.51; for rs10033464, OR 1.14, 95 % CI 1.02-1.26), while rs2200733 was marginal associated with non-CE stroke (OR 1.09, 95 % CI 1.02-1.16). our results demonstrated that two SNPs (rs2200733 and rs1003346) on chromosome 4q25 were limited to the stroke of cardioembolic etiology.
|
24065534 |
2013 |
|
rs10089084
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs1010
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
The odds ratios for noncardioembolic stroke were 1.31 (90% CI 1.07-1.60) for rs3900940 in MYH15, 1.24 (90% CI 1.01-1.5) for rs20455 in KIF6, 1.21 (90% CI 0.99-1.49) for rs1010 in VAMP8, and 1.20 (90% CI 0.95-1.50) for rs10757274 on chromosome 9p21.
|
19752551 |
2009 |
|
rs10118757
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G allele of rs10118757 was associated with an increased risk of stroke, with a per-allele OR of 1.31(95% CI, 1.04-1.65, p=0.025).
|
19427650 |
2009 |
|
rs1041740
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, three variants were associated with increased risk of death from cardiovascular causes (sudden death, fatal myocardial infarction or stroke) during the follow-up: rs9974610 (HR 0.64, 95% CI 0.46-0.88, p=0.005), rs10432782 (HR 1.71, 95% CI 1.16-2.48, p=0.007) and rs1041740 (HR 1.78, 95% CI 1.10-2.78, p=0.02).
|
22608880 |
2012 |
|
rs10423928
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes.
|
26395740 |
2016 |
|
rs1042579
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thrombomodulin Ala455Val Polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study.
|
15574195 |
2004 |
|
rs1042713
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
A recessive model demonstrated a significant association between Arg16/Gly and: absolute supine and upright HR; HUT-induced change in cardiac index (CI), stroke index (SI) and systemic vascular resistance (SVR); and supine and upright norepinephrine values.
|
21807569 |
2011 |
|
rs10432782
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, three variants were associated with increased risk of death from cardiovascular causes (sudden death, fatal myocardial infarction or stroke) during the follow-up: rs9974610 (HR 0.64, 95% CI 0.46-0.88, p=0.005), rs10432782 (HR 1.71, 95% CI 1.16-2.48, p=0.007) and rs1041740 (HR 1.78, 95% CI 1.10-2.78, p=0.02).
|
22608880 |
2012 |
|
rs10435816
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis indicated that rs10435816 (additive model: OR=0.61, 95%CI, 0.41-0.89; recessive model: OR=0.56, 95%CI, 0.40-0.80), rs7025417 (additive model: OR=0.57, 95%CI, 0.39-0.83), rs11792633 (additive model: OR=0.66, 95%CI, 0.46-0.95; recessive model: OR=0.67, 95%CI, 0.49-0.93), and rs7044343 (additive model: OR=0.69, 95%CI, 0.48-0.97; recessive model: OR=0.67, 95%CI, 0.49-0.91) were associated with a decreased risk of large-artery atherosclerosis stroke after adjustment of confounding factors.
|
31660817 |
2019 |
|
rs1043994
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Altogether, 134 Finnish CADASIL patients with p.Arg133Cys mutation were analysed for possible associations between the apolipoprotein E (APOE) genotype, angiotensinogen (AGT) p.Met268Thr polymorphism or neutral p.Ala202Ala NOTCH3 polymorphism and earlier first-ever stroke or migraine.
|
25819272 |
2015 |
|
rs1044498
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
One mutation in GOLGB1 (Y1212C) and another mutation in ENPP1 (K173Q) were confirmed as having significant associations with a decreased risk for stroke.
|
23422753 |
2013 |
|
rs10478723
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
EDN SNP rs1800542 and rs10478723 were associated with increased stroke susceptibility in whites (OR, 2.1; 95% CI, 1.1-4.2 and OR, 2.2; 95% CI, 1.1-4.4; P=0.02 and 0.02, respectively), as were EDNRB SNP rs4885493 and rs10507875, (OR, 1.7; 95% CI, 1.1-2.7 and OR, 2.4; 95% CI, 1.4-4.3; P=0.01 and 0.002, respectively).
|
19661472 |
2009 |
|
rs1048661
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
For R141L the frequencies of G and timidine (T) alleles were 68.2% and 31.7% in stroke patients, and 82.1% and 17.9% in XFS/XFG (P=0.004).
|
20436359 |
2011 |
|
rs10488682
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs104895564
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
One individual with stroke was a carrier for the p.Arg284Ter variant in the NLRP12 gene, which is associated with familial cold autoinflammatory syndrome 2.
|
30183354 |
2018 |
|
rs1050450
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study we have investigated the association of three single nucleotide polymorphisms in glutathione peroxidase (GPx) genes GPX1 rs1050450 (P198L), GPX3 rs2070593 (G930A) and GPX4 rs713041 (T718C) with the risk of cerebral stroke (CS) in patients with essential hypertension (EH).
|
22158110 |
2012 |
|
rs10507875
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
EDN SNP rs1800542 and rs10478723 were associated with increased stroke susceptibility in whites (OR, 2.1; 95% CI, 1.1-4.2 and OR, 2.2; 95% CI, 1.1-4.4; P=0.02 and 0.02, respectively), as were EDNRB SNP rs4885493 and rs10507875, (OR, 1.7; 95% CI, 1.1-2.7 and OR, 2.4; 95% CI, 1.4-4.3; P=0.01 and 0.002, respectively).
|
19661472 |
2009 |
|
rs1051931
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, subgroup analysis showed that a significant association with A379V was found in large-artery atherosclerotic stroke subgroup.
|
24463064 |
2014 |
|
rs1052700
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Six PLIN tag single nucleotide polymorphisms (rs7176403, rs8179078, rs6496589, rs8179043, rs894160, rs1052700) were genotyped in 1571 patients with stroke (690 cerebral thrombosis, 429 lacunar infarction, 452 intracerebral hemorrhage) and 1638 control subjects.
|
18174481 |
2008 |
|
rs1057910
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Eight variants in five candidate genes were examined for the risk of stroke, including the SG13S32 (rs9551963), SG13S42 (rs4769060), SG13S89 (rs4769874), and SG13S114 (rs10507391) variants of the 5-lipoxygenase activating protein (ALOX5AP) gene, the G860A (rs751141) variant of the soluble epoxide hydrolase (EPHX2) gene, the A1075C (rs1057910) variant of the CYP2C9*2 gene, the C430T (rs1799853) variant of the CYP2C9*3 gene, and the A6986G (rs776746) variant of the CYP3A5 gene.
|
24368493 |
2014 |
|
rs10743980
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
The protective association for LRP6 rs2075241 was observed at a similar magnitude across ischaemic stroke subtypes, whilst the effects of rs23022685, rs10492120 and rs10743980 were most apparent for cardioembolic and large vessel stroke.
|
26031789 |
2015 |
|
rs10757274
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
The odds ratios for noncardioembolic stroke were 1.31 (90% CI 1.07-1.60) for rs3900940 in MYH15, 1.24 (90% CI 1.01-1.5) for rs20455 in KIF6, 1.21 (90% CI 0.99-1.49) for rs1010 in VAMP8, and 1.20 (90% CI 0.95-1.50) for rs10757274 on chromosome 9p21.
|
19752551 |
2009 |
|
rs10848683
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
And rs10848683 was also found to associate with LAA stroke under recessive model (p = 0.027, OR = 0.618, 95% CI: 0.403-0.947) after adjustment for gender and age.
|
29683785 |
2018 |