rs12425791
|
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
These findings indicate that rs12425791 G>A polymorphism may be a low-penetrance susceptibility marker of stroke in Asian populations and further studies are warranted to verify this association.
|
26312640 |
2016 |
rs12425791
|
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study (GWAS) identified two common polymorphisms (rs12425791 and rs11833579) on chromosome 12p13 that confer risk to stroke, particularly for large artery atherosclerotic (LAA) stroke.
|
26687183 |
2016 |
rs12425791
|
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
These results suggested that the rs12425791 and rs11833579 polymorphisms on Chromosome 12p13 may be associated with the risk of LAA stroke and might be used as candidate biomarkers for LAA stroke susceptibility.
|
26145198 |
2015 |
rs12425791
|
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
rs12425791 and rs11833579 were not associated with age of stroke onset (P = 0.786 and 0.340, respectively).
|
24995625 |
2014 |
rs12425791
|
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
This is a precedent study that found genetic variants of rs12425791 and rs11833579 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke in Taiwan.
|
22212150 |
2012 |
rs12425791
|
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies (GWAS) have identified two key SNPs (rs11833579 and rs12425791) on chromosome 12p13 that were significantly associated with stroke in Caucasians.
|
22938733 |
2012 |
rs12425791
|
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
In 2009, a GWAS has confirmed that rs11833579 and rs12425791 near the NINJ2 gene could increase the stroke and ischemic stroke (IS) risk.
|
22795341 |
2012 |
rs12425791
|
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
Recent genome-wide association (GWA) studies have identified two intergenic single nucleotide polymorphisms (SNPs) (rs11833579 and rs12425791) on chromosome 12p13 and within 11 kb of the NINJ2 gene that were significantly associated with stroke in Caucasians.
|
21376321 |
2011 |
rs12425791
|
|
Cerebrovascular accident
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our data suggest that rs12425791 on chromosome 12p13 is a genetic marker for atherothrombotic stroke in multiethnic population.
|
20448654 |
2010 |
rs12425791
|
|
Cerebrovascular accident
|
A |
0.890 |
GeneticVariation
|
GWASDB |
Genomewide association studies of stroke.
|
19369658 |
2009 |
rs12425791
|
|
Cerebrovascular accident
|
A |
0.890 |
GeneticVariation
|
GWASCAT |
Genomewide association studies of stroke.
|
19369658 |
2009 |
rs2107595
|
|
Cerebrovascular accident
|
|
0.850 |
GeneticVariation
|
BEFREE |
In HDAC9 SNP rs2107595 risk allele-positive LVAS patients, there were 155 genes differentially expressed compared to risk allele-negative patients (fold change > ;1.2;, p < 0.05).
|
29651704 |
2019 |
rs2107595
|
|
Cerebrovascular accident
|
|
0.850 |
GeneticVariation
|
BEFREE |
Results- Targeted resequencing of the <i>HDAC9</i> locus in patients with atherosclerotic stroke and controls supported candidacy of rs2107595 as the causative single nucleotide polymorphism.
|
31500558 |
2019 |
rs2107595
|
|
Cerebrovascular accident
|
|
0.850 |
GeneticVariation
|
BEFREE |
Apolipoprotein L1 (APOL1) rs73885319 (OR = 1.52; CI: 1.09-2.13, P-value = .013), rs2383207 in CDKN2A/CDKN2B (OR = 3.08; CI: 1.15-8.26, P -value = .026) and rs2107595 (OR = 1.70; CI: 1.12-2.60, P-value = .014) and rs28688791 (OR = 1.52; CI: 1.03-2.26, P-value = .036) in HDAC9 gene were associated with SVD stroke at 0.05 significance level.
|
28975602 |
2018 |
rs2107595
|
|
Cerebrovascular accident
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
|
29531354 |
2018 |
rs2107595
|
|
Cerebrovascular accident
|
|
0.850 |
GeneticVariation
|
BEFREE |
Our results revealed statistically significant associations of the rs2107595 (T/C) polymorphism with an increased risk of stroke in the allele, codominant and dominant models.
|
28145521 |
2017 |
rs2107595
|
|
Cerebrovascular accident
|
|
0.850 |
GeneticVariation
|
BEFREE |
We further performed detailed plaque phenotyping and genotyping of rs2107595, the lead single-nucleotide polymorphism for large-vessel stroke, in carotid endarterectomy samples of 1858 subjects from the Athero-Express study.
|
25388417 |
2015 |
rs2107595
|
|
Cerebrovascular accident
|
A |
0.850 |
GeneticVariation
|
GWASDB |
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
|
23041239 |
2012 |
rs2107595
|
|
Cerebrovascular accident
|
A |
0.850 |
GeneticVariation
|
GWASCAT |
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
|
23041239 |
2012 |
rs11984041
|
|
Cerebrovascular accident
|
|
0.830 |
GeneticVariation
|
BEFREE |
The variant rs556621 but not rs11984041 may increase susceptibility of LAA stroke in the Xinjiang Uyghur population.
|
25307434 |
2015 |
rs11984041
|
|
Cerebrovascular accident
|
|
0.830 |
GeneticVariation
|
BEFREE |
A recent Genome-Wide Association study (GWAS) identified rs11984041 on HDAC9 gene to be significantly associated with stroke in a Caucasian population.
|
23828597 |
2013 |
rs11984041
|
|
Cerebrovascular accident
|
A |
0.830 |
GeneticVariation
|
GWASDB |
We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57).
|
22306652 |
2012 |
rs11984041
|
|
Cerebrovascular accident
|
|
0.830 |
GeneticVariation
|
BEFREE |
We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57).
|
22306652 |
2012 |
rs11984041
|
|
Cerebrovascular accident
|
A |
0.830 |
GeneticVariation
|
GWASCAT |
We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57).
|
22306652 |
2012 |
rs2200733
|
|
Cerebrovascular accident
|
|
0.820 |
GeneticVariation
|
BEFREE |
Subsequently subgroup analysis indicated that both rs2200733 and rs10033464 conferred increased risk for cardioembolic stroke (CE str</span>oke) (for rs2200733, OR 1.38, 95 % CI 1.26-1.51; for rs10033464, OR 1.14, 95 % CI 1.02-1.26), while rs2200733 was marginal associated with non-CE stroke (OR 1.09, 95 % CI 1.02-1.16). our results demonstrated that two SNPs (rs2200733 and rs1003346) on chromosome 4q25 were limited to the stroke of cardioembolic etiology.
|
24065534 |
2013 |