|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Collectively, our analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations.
|
27328316 |
2016 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both methods' results showed two identical significant SNPs associated with the A β-42 levels in CSF (rs2075650 at intron region TOMM40 with p-value ≥ 1 × 10-16 and rs439401 in the intergenic region of LOC100129500 and APOC1 with p-value ≥ 1 × 10-9) and highlighted APOC1 and TOMM40, which are well-known genes previously associated with AD.
|
26576771 |
2016 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We conclude that rs2075650 in TOMM40 gene may increase the risk of Alzheimer disease.
|
26572157 |
2016 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Similarly, our evidence suggested that allele A of TOMM40 rs2075650 polymorphism was a risk factor for AD (OR=2.87, 95% CI: 2.46-3.34, P value <0.001).
|
26795201 |
2016 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (p = 0.0054) and CD33 (rs3865444) with smaller intracranial volume (p = 0.0058).
|
25670335 |
2015 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our prevalent case study comparing prevalent AD cases (n = 428) with participants with no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3865444 (CD33) with late-onset AD that were robust to adjustment with age and apolipoprotein E ε4 genotype.
|
24176626 |
2014 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
There were four significant associations between genotypes and phenotypes of AD patients: CR1 SNP rs11803956 correlated with Mini-Mental State Examination (MMSE) score (β=1.718, Pcorrected=0.002); ABCA7 SNP rs3752232 correlated with Rey Complex Figure Test (RCFT) copy score (β=-6.861, Pcorrected=0.013); APOE SNP rs2075650 correlated with the percentile of RCFT copy score (β=14.005, Pcorrected=0.021) and the percentile of total score in phonemic fluency (β=11.052, Pcorrected=0.035).
|
24530172 |
2014 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three SNPs [rs429358 in APOE: odds ratio (OR)=4.24, 95% confidence interval (CI)=3.01-5.96, P=1.23×10; rs2075650 in APOE: OR=3.57, 95% CI=2.51-5.06, P=1.23×10; and rs677909 in PICALM: OR=0.63, 95% CI=0.49-0.81, P=0.00036, log additive model] were significantly associated with AD susceptibility after correction for multiple testing.
|
22975751 |
2014 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Only TOMM40 rs2075650 showed association with clinical AD after adjusting for APOE-ε4 (p = 0.007), but not after multiple test correction (p>0.05).
|
23573206 |
2013 |
|
rs2075650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, the rs2075650 single nucleotide polymorphism in the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene was identified as a risk factor for AMD and Alzheimer disease.
|
24146538 |
2013 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We believe that our findings provide important information regarding the rs2373115 variant and expression of nearby genes with respect to AD risk.
|
30088171 |
2018 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The fixed effect model analysis again showed no significant association between r</span>s2373115</span> and AD in these pooled populations.
|
28320126 |
2017 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was no significant association between SNPs of GAB2 rs2373115 (G > T) and PICALM rs541458 (C > T) and AD.
|
26611835 |
2016 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We aimed to investigate the GAB2 rs2373115 and BDNF rs6265 polymorphisms and the risk of AD in a Brazilian sample.
|
25853819 |
2015 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele.
|
23525328 |
2013 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
GAB2 polymorphism rs2373115 confers susceptibility to sporadic Alzheimer's disease.
|
24161894 |
2013 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results showed negative results, indicating GAB2 rs2373115 polymorphism was not a remarkable factor in developing Alzheimer disease among Mongolian.
|
20188796 |
2010 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
GAB2 rs2373115 marker does not modify the risk of Alzheimer's disease in Spanish APOE epsilon 4 carriers.
|
19262956 |
2009 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common polymorphism (rs2373115) in the GRB-associated binding protein 2 (GAB2) gene has been recently associated with the risk of developing Alzheimer's disease (AD) in 644 apolipoprotein E (ApoE) epsilon4 carriers.
|
19276544 |
2009 |
|
rs2373115
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases.
|
18272374 |
2008 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Thus, in African Americans the interactive effects of ABCA7 rs3764650 and aerobic fitness likely compound overall ABCA7-related AD risk, and may contribute to health disparities whereby African Americans are at a higher risk for dementia, with double the prevalence of AD.
|
31024289 |
2019 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The associations of rs3764650 with CSF Aβ<sub>1-42</sub>, t-tau and p-tau were analyzed in non-dementia AD, including preclinical and prodromal AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
|
30596067 |
2018 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races.
|
29782324 |
2018 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
ABCA7 rs3764650 polymorphism was significantly associated with A</span>D risk (OR=1.21, 95% CI 1.16-1.26, P<0.00001; I2=5%).
|
29441941 |
2017 |