|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes disease stage was marginally significantly associated with the frequency of the T variant at rs12255372 (p=0.057; adjusted p=0.017) but not at rs7903146 (p=0.5; adjusted p=0.2).
|
18282631 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes incidence in the DESIR cohort.
|
17977958 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The minor allele frequency for rs7903146 was different between TCP and FCPD patients carrying the N34S SPINK1 variant but did not reach statistical significance (OR = 1.59, 95% CI = 0.93-2.70, P = 0.09), while, TCF7L2variant showed a statistically significant association between TCP and FCPD patients carrying the 26V allele (OR = 1.69, 95% CI = 1.11-2.56, P = 0.013).
|
18706099 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with lower estimated GFR (P = 0.01) and higher cystatin C (P = 0.004) in adjusted analyses overall and among those without diabetes.
|
18650481 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes susceptibility.
|
19169495 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk in a Brazilian population and to assess the use of this genetic marker in improving diabetes risk prediction in the general population.
|
19055834 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
This result suggests that the increased health risk associated with rs7903146 genotype is specific to diabetes.
|
18437354 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Concerned with predisposition for diabetes mellitus in obese children, we tested if risk genotypes TC and TT of rs7903146 are more common in obese children with increased homeostasis model assessment insulin resistance index (HOMA-IR) compared to obese controls with normal HOMA-IR.
|
18546086 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903146) for diabetes.
|
18268068 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of 100K SNPs, one (rs7100927) was in moderate LD (r2 = 0.50) with TCF7L2 (rs7903146), and was associated with risk of diabetes (Cox p-value 0.007, additive hazard ratio for diabetes = 1.56) and with tFPG (GEE p-value 0.03).
|
17903298 |
2007 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using four TCF7L2 single nucleotide polymorphisms (SNPs; including the two most associated in the previous study), we conducted a case-control study in 2,158 type 2 diabetic subjects and 2,574 control subjects and a family-based association analysis in 388 parent-offspring trios all from the U.K. All SNPs showed powerful associations with diabetes in the case-control analysis, with strongest effects at rs7903146 (allele-wise relative risk 1.36 [95% CI 1.24-1.48], P = 1.3 x 10(-11)).
|
16936215 |
2006 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Over an average period of three years, participants with the risk-conferring TT genotype at rs7903146 were more likely to have progression from impaired glucose tolerance to diabetes than were CC homozygotes (hazard ratio, 1.55; 95 percent confidence interval, 1.20 to 2.01; P<0.001).
|
16855264 |
2006 |