|
rs1035209
|
|
Colorectal Carcinoma
|
T |
0.810 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
|
rs10380
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR gene (rs1801133 and rs1801131) and in the MTRR gene (rs1801394, rs1532268, rs162036, and rs10380) with the risk for colorectal cancer in 666 patients and 1377 controls from the Czech Republic.
|
21211571 |
2011 |
|
rs1040264140
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The observed statistically significant associations included a decreased CRC risk for TGFBR1 IVS7G+24A minor allele carriers (odds ratio (OR): 0.72, 95% confidence interval (CI): 0.53-0.97), less aggressive tumors with Dukes' stage A+B for carriers of LTBP4 Thr750Ala and BAMBI T-779A minor alleles (OR: 0.58, 95%CI: 0.36-0.93 and OR: 0.51, 95%CI: 0.29-0.89, respectively) and worse survival for FURIN C-229T heterozygotes (hazard ratio: 1.63, 95%CI: 1.08-2.46).
|
19998449 |
2010 |
|
rs10411210
|
|
Colorectal Carcinoma
|
C |
0.840 |
GeneticVariation
|
GWASCAT |
We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)).
|
19011631 |
2008 |
|
rs10411210
|
|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
Among the 22 SNPs, two (rs1321311G>T in CDKN1A and rs10411210C>T in RHPN2) were significantly associated with the survival outcomes of CRC in a multivariate survival analysis.
|
25799222 |
2015 |
|
rs10411210
|
|
Colorectal Carcinoma
|
C |
0.840 |
GeneticVariation
|
GWASDB |
We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)).
|
19011631 |
2008 |
|
rs10411210
|
|
Colorectal Carcinoma
|
C |
0.840 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
|
rs10411210
|
|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
Collectively, our analysis further highlights significant association bet</span>ween rs10411210 polymorphism and colorectal cancer.
|
26349980 |
2015 |
|
rs10411210
|
|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
|
rs10411210
|
|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
In addition, a variant previously identified through fine-mapping in this GWAS in the region 19q13.1, rs7252505, was confirmed to be more strongly associated with CRC in the African American replication set than the variant originally reported in Europeans (rs10411210).
|
28295283 |
2017 |
|
rs10411210
|
|
Colorectal Carcinoma
|
|
0.840 |
GeneticVariation
|
BEFREE |
The present results suggest that the genetic variants of the CDKN1A (rs1321311) and RHPN2 (rs10411210) genes can be used as prognostic biomarkers for patients with surgically resected colorectal cancer.
|
25799222 |
2015 |
|
rs10411210
|
|
Colorectal Carcinoma
|
C |
0.840 |
GeneticVariation
|
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |
|
rs10414971
|
|
Colorectal Carcinoma
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs1041981
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated with an increased risk of CRC in women (P(trend) = 0.003) but not in men (P(interaction) = 0.06); the LTA_rs1041981_A allele was associated with a decreased risk for CRC in women (P(trend) = 0.02), with an opposite effect in men (P(trend) = 0.05; P(interaction) = 0.002); the CDKAL1_rs7754840_C allele was associated with a decreased risk for CRC in men (P(trend) = 0.03), with no effect in women (P(interaction) = 0.03).
|
22419714 |
2012 |
|
rs1042028
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
From this study, we conclude that the SULT1A1 R213H polymorphism is not linked with colorectal cancer in this elderly Australian population.
|
12165038 |
2002 |
|
rs1042028
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates that there is no association between the SULT1A1 R213H polymorphism and CRC.
|
21695180 |
2011 |
|
rs1042028
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Of the 224 SNPs investigated, 20 potential candidates associated with CRC were identified, including IL6 -174G>C (g.22062318G>C), XRCC1 c.685 C>T (p.Arg194Trp), PPARGC1A g.92945042C>T (3'UTR 96516), GSTP1 c.342A>C (p.Ile105Val), GSTM1 c.573C>G (p.Lys173Asn), and SULT1A1 g.19934792G>A (p.Arg213His).
|
16395669 |
2006 |
|
rs1042522
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Age of diagnosis of CRC in HNPCC patients is therefore more complex than that predicted by the R72P TP53 polymorphism alone, suggesting an inter-relationship with other genetic and/or environmental factors.
|
16353134 |
2006 |
|
rs1042522
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |
|
rs1042522
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers.
|
17599946 |
2007 |
|
rs1042522
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.
|
29872345 |
2018 |
|
rs1042522
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population.
|
22393962 |
2011 |
|
rs1042522
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The gene-gene interaction between TP53 Arg72Pro and MDM2 T309G may interact in carcinogenesis of CRC in Chinese, especially in smokers, and this kind of interaction is associated with onset age of CRC.
|
22744426 |
2012 |
|
rs1042522
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that R72P variant seems to be associated with high risk for development of CRC but carries low risk for development of UC.
|
20309662 |
2010 |
|
rs1042522
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms and the risk of CRC.
|
23183747 |
2013 |