|
rs1537415
|
|
Acute periodontitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Moreover, SNPs rs1333048 and rs1537415, previously associated with AgP in other population, was not validated to Brazilian population.
|
30030838 |
2019 |
|
rs1537415
|
|
Acute periodontitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The study independently replicated the finding that rs1537415, a variant in glycosyl transferase gene GLT6D1, is associated with AgP and provided the first report of genetic associations with AgP in a Sudanese population.
|
25682733 |
2015 |
|
rs1537415
|
|
Acute periodontitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found AgP to be strongly associated with the intronic SNP rs1537415, which is located in the glycosyltransferase gene GLT6D1.
|
19897590 |
2010 |
|
rs4986791
|
|
Acute periodontitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP).
|
26079505 |
2015 |
|
rs4986791
|
|
Acute periodontitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
All case-control studies evaluating the TLR4 Asp299Gly and Thr399Ile polymorphisms in chronic or aggressive periodontitis were identified.
|
19426173 |
2009 |
|
rs4986791
|
|
Acute periodontitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
One hundred and eleven patients with aggressive periodontitis and 80 periodontally healthy controls were genotyped for four functional variants in the TLR4 gene (c.896A>G and c.1196C>T) and in the IL-18 promoter (c.-368G>C and c.-838C>A).
|
18983635 |
2008 |
|
rs1333048
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, SNPs rs1333048 and rs1537415, previously associated with AgP in other population, was not validated to Brazilian population.
|
30030838 |
2019 |
|
rs1333048
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We analyzed our cohort consisting of patients suffering from the most severe form of AgP, generalized AgP (gAgP) (n = 130) and appropriate periodontally healthy control individuals (n = 339) by genotyping four tagging SNPs (rs2891168, rs1333042, rs1333048 and rs496892), located in the chromosomal region 9p21.3, that have been associated with AgP.
|
20696043 |
2010 |
|
rs1800629
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Tumor necrosis factor-α G-308A (rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies.
|
26750615 |
2016 |
|
rs1800629
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to assess the effect of TNF-α -308G/A (rs1800629), -238G/A (rs361525) and -863C/A (rs1800630) polymorphisms on either chronic (CP) or aggressive periodontitis (AgP) risk.
|
24905365 |
2014 |
|
rs1800872
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subgrouping data according to periodontitis type revealed that rs1800872 was associated with both chronic periodontitis (A allele vs. C allele: p = 0.011, OR = 1.72, 95% CI: 1.13-2.62) and aggressive periodontitis (A allele vs. C allele: p = 0.038, OR = 1.32, 95% CI: 1.02-1.72).
|
30343215 |
2019 |
|
rs1800872
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The objective of the current review was to investigate the association between IL10 polymorphisms - 1082 A > G (rs1800896), -819C > T (rs1800871), - 592 A > C (rs1800872) and the risk of either chronic periodontitis or aggressive periodontitis.
|
30348144 |
2018 |
|
rs3795391
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This family-based association study supports the previous findings that SNP rs3795391 (A > G) of the S100A8 gene might contribute to AgP susceptibility.
|
19210342 |
2009 |
|
rs3795391
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The G+ genotype/G allele may be considered to exert a significant protective effect in males against AgP (Genotype: rs3795391: P= 0.032, rs3806232: P= 0.017; Allele: rs3795391: P= 0.024, rs3806232: P= 0.013).
|
17069562 |
2007 |
|
rs3806232
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our previous population-based study found an association between two polymorphisms, rs3795391 (A > G) and rs3806232 (A > G), in the upstream region of the S100A8 gene and aggressive periodontitis (AgP) in Chinese people.
|
19210342 |
2009 |
|
rs3806232
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The G+ genotype/G allele may be considered to exert a significant protective effect in males against AgP (Genotype: rs3795391: P= 0.032, rs3806232: P= 0.017; Allele: rs3795391: P= 0.024, rs3806232: P= 0.013).
|
17069562 |
2007 |
|
rs4252120
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Rs4252120 was not associated with CP.However, a haplotype block downstream of PLG and not in linkage disequilibrium with rs4252120 (r<sup>2 </sup> = .08) was associated with both AgP (rs1247559; p = .002, odds ratio [OR] = 1.33) and CP (p = .02, OR = 1.15).
|
28548211 |
2017 |
|
rs4252120
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In-depth genotyping of 46 published CAD risk loci of genome-wide significance in the worldwide largest case-control sample of the severe early-onset phenotype aggressive periodontitis (AgP) with the Illumina Immunochip (600 German AgP cases, 1448 controls) and the Affymetrix 500K array set (283 German AgP cases and 972 controls) highlighted ANRIL as the major risk gene and revealed further associations with AgP for the gene PLASMINOGEN (PLG; rs4252120: P=5.9×10(-5); odds ratio, 1.27; 95% confidence interval, 1.3-1.4 [adjusted for smoking and sex]; 818 cases; 5309 controls).
|
25466412 |
2015 |
|
rs4986790
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP).
|
26079505 |
2015 |
|
rs4986790
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
One hundred and eleven patients with aggressive periodontitis and 80 periodontally healthy controls were genotyped for four functional variants in the TLR4 gene (c.896A>G and c.1196C>T) and in the IL-18 promoter (c.-368G>C and c.-838C>A).
|
18983635 |
2008 |
|
rs5030879
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
FPR1 SNP c.348T>C is associated with AgP in African Americans.
|
19254133 |
2009 |
|
rs5030879
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Formylpeptide receptor single nucleotide polymorphism 348T>C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis.
|
19722801 |
2009 |
|
rs6667202
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Only the SNP rs6667202 was associated with AgP in a Brazilian population, being the minor C allele protective against AgP.
|
30030838 |
2019 |
|
rs6667202
|
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Upon covariate adjustment for smoking and gender, in the pooled German-Austrian AgP sample, IL10 SNP rs6667202 was associated with p = 0.016, OR = 0.77 (95% CI = 0.6-0.95), and in the Dutch AgP sample, adjacent IL10 SNP rs61815643 was associated with p = 0.0009, OR = 2.31 (95% CI = 1.4-3.8).
|
23587006 |
2013 |
|
rs1042229
|
|
Acute periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Six SNPs were identified including two located in the FPR1 second extracellular loop that were significantly associated with the AP phenotype in African-American patients (p.R190W, P=0.0033; and p.N192K, P=0.0018).
|
12595898 |
2003 |