Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519847
rs1057519847
EGFR
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE Occurrence and severity of skin rash was significantly associated with trough concentration in patients with exon 19 deletions but not exon 21 L858R point mutations. 30039303

2018
dbSNP: rs1057519848
rs1057519848
EGFR
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE Occurrence and severity of skin rash was significantly associated with trough concentration in patients with exon 19 deletions but not exon 21 L858R point mutations. 30039303

2018
dbSNP: rs1128503
rs1128503
ABCB1
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE Patients with ABCB1 rs1128503 TT genotype had greater risk of skin rash and diarrhea. 27089937

2017
dbSNP: rs11942466
rs11942466
LOC107986229
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE SNP rs11942466 located close to rs9996584 had a borderline significant association, and none of the other SNPS were significantly associated with risk of skin rash. 29771169

2018
dbSNP: rs121434568
rs121434568
EGFR
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE Occurrence and severity of skin rash was significantly associated with trough concentration in patients with exon 19 deletions but not exon 21 L858R point mutations. 30039303

2018
dbSNP: rs1893592
rs1893592
UBASH3A
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE A statistically significant association was observed between UBASH3A rs1893592 C allele and skin rash, oral ulcer and arthritis (p<0.05). 25843625

2015
dbSNP: rs2069762
rs2069762
IL2
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE However, we demonstrated an association between the SNP in IL2 (rs2069762) and the onset of skin rash (P = 0·0001). 30203425

2019
dbSNP: rs2234693
rs2234693
ESR1
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE Results The SNP rs2234693 was not associated with SLE per se but the minor allele rs2234693-C was correlated with the presence of nephritis and discoid skin rash. 27681518

2017
dbSNP: rs750713244
rs750713244
EGFR
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE The EGFR polymorphisms, 497G/A (P=0.008), and the haplotypes of the promoter variants, EGFR-216G/T and -191C/A (P=0.029), were associated with the appearance of skin rash. 22158333

2013
dbSNP: rs8176345
rs8176345
CYP27B1
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE Although exploratory, this study indicates rs8176345 in CYP27B1 gene as significantly correlated with erlotinib-induced SR in aNSCLC patients probably through a mechanism mediated by vitamin D3 and inflammation at skin level. 26607259

2016
dbSNP: rs9996584
rs9996584
LOC107986229
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 GeneticVariation BEFREE SNP rs11942466 located close to rs9996584 had a borderline significant association, and none of the other SNPS were significantly associated with risk of skin rash. 29771169

2018