|
rs1217691063
|
|
Acute leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
MTHFR gene polymorphisms, the c. 677C>T and c. 1298A>C have been implicated as risk factors for several types of cancers as the acute leukemia.
|
28374953 |
2018 |
|
rs1217691063
|
|
Acute leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.
|
22706675 |
2012 |
|
rs1217691063
|
|
Acute leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in the Korean population.
|
17970089 |
2007 |
|
rs1217691063
|
|
Acute leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
We retrospectively analyzed the incidence of MTHFR C677T and the influence of genotype on methotrexate (MTX) toxicity in patients with acute leukemia undergoing maintenance chemotherapy.
|
12453860 |
2002 |
|
rs1045642
|
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggest that the ABCB1 G2677T and C3435T sequence variations may affect susceptibility to acute leukemia.
|
27706688 |
2016 |
|
rs1045642
|
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
ABCB1 3435C > T polymorphisms may be associated with susceptibility to acute leukemia, and ABCB1 polymorphisms might be a sensitive indicator for predicting efficacy of MTX therapy in the treatment of acute leukemia.
|
25921280 |
2015 |
|
rs1045642
|
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India.
|
21133625 |
2010 |
|
rs77375493
|
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
A high JAK2(V617F) allele burden was correlated with the transformation to myelofibrosis (p<0.0001), but not with the transformation to acute leukemia.
|
22818858 |
2013 |
|
rs77375493
|
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
JAK2 V617F mutation was detected after transformation to CMML in 1 of them; in the other, a novel translocation t(5;12)(p13;q24) was observed at the time of progression to acute leukemia.
|
21658659 |
2011 |
|
rs77375493
|
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
|
16037387 |
2005 |
|
rs397507444
|
|
Acute leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.
|
22706675 |
2012 |
|
rs397507444
|
|
Acute leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in the Korean population.
|
17970089 |
2007 |
|
rs1048943
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of the present study suggest that CYP1A1 Ile462Val polymorphism might be a low-penetrant risk factor for acute leukemia.
|
23056546 |
2012 |
|
rs1057519766
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K</span>-transduced primary hematopoietic progenitor cells developed acute leukemia (latency of 68, 77, and 273 days), while no hematological malignancy was observed in the control groups including FLT3-ITD.
|
26891877 |
2016 |
|
rs111033563
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We studied the prevalence of 12 hereditary hemochromatosis (HH) gene mutations (C282Y, V53M, V59M, H63D, H63H, S56C, Q127H, E168Q, E168X, W169X and Q283P in the HFE gene and Y250X in the TFR2 gene) and its correlation with the iron status in 82 adult patients with acute leukemia (AL); 48 patients (58.5%) were affected by acute myeloid leukemia (AML) and 34 patients (41.5%) by acute lymphoblastic leukemia (ALL); 27 patients (32.9%) had at least one HH gene mutation (6 heterozygous for C282Y, 6 homozygous for H63D, 13 heterozygous for H63D and 2 heterozygous for S56C).
|
15863206 |
2005 |
|
rs1137101
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the study was to evaluate bone marrow and peripheral blood leptin level and frequency of distribution of leptin receptor gene polymorphism Gln223Arg in children with acute leukemia.
|
17072067 |
2006 |
|
rs11978267
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two common polymorphisms in the IKZF1 gene (rs4132601 and rs11978267 variants) have been reported to be associated with childhood acute leukemia (AL) risk, however the results were inconsistent.
|
25423013 |
2014 |
|
rs121434592
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrated that the AKT1 E17K mutation occurs in breast cancers at a low frequency, and that it is rare in other common cancers, including colorectal, lung, gastric and hepatocellular carcinomas and acute leukaemias.
|
18392055 |
2008 |
|
rs121918464
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, Ptpn11(E76K) mutation has non-lineage-specific effects on malignant transformation of hematopoietic cells and initiates acute leukemias at various stages of hematopoiesis.
|
21930766 |
2011 |
|
rs1239681664
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India.
|
21133625 |
2010 |
|
rs13181
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The effect of XPD/ERCC2 Lys751Gln polymorphism on acute leukemia risk: a systematic review and meta-analysis.
|
24486506 |
2014 |
|
rs1325757098
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism may contribute to development of depressive symptomatology in patients undergoing stressful life events, such as diagnosis of acute leukemia and preparation for HSCT.
|
22652301 |
2013 |
|
rs1470755915
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we aimed to evaluate the association between genotype or allele of CYP2B6 516G>T SNP and acute leukemia and myelodysplastic syndrome (MDS).
|
20878158 |
2011 |
|
rs1532268
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.
|
22706675 |
2012 |
|
rs1799929
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between rs1799929 and decreased AL risk was found in the co-dominant (OR 0.82, 95% CI 0.70-0.97), homozygous (OR 0.65, 95% CI 0.46-0.93), heterozygous (OR 0.71, 95% CI 0.51-1.00), and the recessive model (OR 0.68, 95% CI 0.49-0.94) in the Caucasian group.
|
30896661 |
2019 |