|
rs3769839
|
|
Cholangiocarcinoma
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.
|
28779025 |
2018 |
|
rs7731017
|
|
Cholangiocarcinoma
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.
|
28779025 |
2018 |
|
rs12979860
|
|
Cholangiocarcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Levels of ISGs and IFNL2/3 mRNAs were lower in IFNL3 rs12979860 CC patients compared with non-CC patients, and in treatment responders, compared with nonresponders.
|
26020282 |
2016 |
|
rs12979860
|
|
Cholangiocarcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
|
23936821 |
2013 |
|
rs1003723
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer.
|
18296645 |
2008 |
|
rs1045642
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
C3435T genotype was an independent predictive factor of good response in breast (response >50 %, i.e., Sataloff T-A and T-B): OR: 4.6 (95 % CI: 1.3-16.1), p = 0.015, for TT patients versus CT and CC patients.
|
23666532 |
2013 |
|
rs104886003
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Next-generation sequencing detected mutations at p.Q61H (c.183A>C) of KRAS and p.E545K (c.1633G>A) of PIK3CA, keeping in line with similarity to conventional cholangiocarcinoma.
|
30591492 |
2019 |
|
rs1126579
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.
|
18676870 |
2008 |
|
rs1126580
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.
|
18676870 |
2008 |
|
rs113488022
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
BRAF inhibitors showed activity in BRAF V600E mutated cholangiocarcinomas and pancreatic carcinomas in non-first line settings.
|
31221175 |
2019 |
|
rs11635252
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant decrease was identified in the total cholesterol (TC), triglyceride (TG), and weight in those with CC phenotype compared with those with CT phenotype among the cases with rs11635252 (P < .05).CRTC3 polymorphism was associated with the onset of acute coronary syndrome in Han Chinese patients, which may be related to the imbalance of the lipid metabolism.
|
29979427 |
2018 |
|
rs11887534
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriers of the CG genotype of ABCG8 rs11887534 had higher risk of biliary stones [odds ratio (OR) = 2.3, 95% confidence interval (CI) 0.82-6.5), gallbladder cancer (OR = 4.3, 95% CI 1.7-10.4) and bile duct cancer (OR = 1.94, 95% CI 0.64-5.91), compared with carriers of the GG genotype.
|
21062971 |
2011 |
|
rs1194919682
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Transforming growth factor beta (TGF-β) mRNA expression was assessed according to T869C polymorphism and CC patients presented a higher TGF-β expression but not significant when compared to other genotypes (p = 0.064).
|
22941282 |
2012 |
|
rs1217691063
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population.
|
17201138 |
2007 |
|
rs121913377
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
BRAF inhibitors showed activity in BRAF V600E mutated cholangiocarcinomas and pancreatic carcinomas in non-first line settings.
|
31221175 |
2019 |
|
rs17851045
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Next-generation sequencing detected mutations at p.Q61H (c.183A>C) of KRAS and p.E545K (c.1633G>A) of PIK3CA, keeping in line with similarity to conventional cholangiocarcinoma.
|
30591492 |
2019 |
|
rs17851045
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Next-generation sequencing detected mutations at p.Q61H (c.183A>C) of KRAS and p.E545K (c.1633G>A) of PIK3CA, keeping in line with similarity to conventional cholangiocarcinoma.
|
30591492 |
2019 |
|
rs1799782
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped five non-synonymous single-nucleotide polymorphisms of three genes, including the human homolog of the 8-oxoguanine glycosylase 1 Ser326Cys, X-ray repair cross-complementing protein 1 Arg194Trp, Arg280His and Arg399Gln and poly (adenosine diphosphate ribose) polymerase 1 Val762Ala in 87-94 matched case-control pairs, and examined relations between those polymorphisms and the risk of cholangiocarcinoma.
|
24049014 |
2013 |
|
rs2072671
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
For CDA rs2072671 (A>C), AC and CC patients had a lower risk of neutropenia than AA patients (P=0.01, hazard ratio: 0.61, 95% confidence interval: 0.41-0.89).
|
30889042 |
2019 |
|
rs2076310
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Relative to individuals with the RXR-beta C51T (rs2076310) CC genotype, those having the TT genotype had a 1.6-fold risk for bile duct cancer [odds ratio (OR) = 1.67; 95% confidence interval (CI) = 0.99-2.84], with a more pronounced association among men (OR = 2.30; 95% CI = 1.14-4.65; P interaction = 0.07).
|
18375961 |
2008 |
|
rs2106261
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further, neutrophil/lymphocyte (N/L) ratio, C-reactive protein (CRP), and interleukin-6 (IL-6) expression levels were lower in PAF patients with the ZFHX3 SNP rs2106261 minor allele (TT+TC) than in CC patients (N/L ratio: CC 2.22 ± 0.08, TT+TC 1.98 ± 0.06, p = 0.018; CRP: CC 0.103 ± 0.009 mg/dl, TT+TC 0.076 ±0.007 mg/dl, p = 0.016; IL-6: CC 60.3 ± 3.0 pg/ml, TT+TC 52.8 ± 2.3 pg/ml, p = 0.04).
|
30180182 |
2018 |
|
rs2230054
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.
|
18676870 |
2008 |
|
rs2266788
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also, homozygous risk allele of rs2266788 (CC) significantly associated with risk of MI and UA in patients of chronic stable angina (CSA) patients.
|
29309886 |
2018 |
|
rs2287622
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a trend towards significant association of V444A with CC.
|
21691113 |
2011 |
|
rs2289278
|
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In children sensitized to certain allergens, a genetic predisposition (rs2289278 genotype CC) significantly increased the risk of AD.
|
26712523 |
2016 |