|
rs12252
|
|
Influenza A
|
|
0.040 |
GeneticVariation
|
BEFREE |
Moreover, the risk of <i>IFITM3</i> rs12252-C variant for severe IVI was specific for both influenza A and influenza B.
|
28713779 |
2017 |
|
rs12252
|
|
Influenza A
|
|
0.040 |
GeneticVariation
|
BEFREE |
Several studies suggest that the CC genotype at the single nucleotide polymorphism (SNP) rs12252 of IFITM3 confers a genetic predisposition to pandemic influenza A in Europeans and Han Chinese, although one study in a British cohort failed to show an association.
|
28813716 |
2017 |
|
rs12252
|
|
Influenza A
|
|
0.040 |
GeneticVariation
|
BEFREE |
The IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1)pdm09.
|
27351739 |
2016 |
|
rs12252
|
|
Influenza A
|
|
0.040 |
GeneticVariation
|
BEFREE |
IFITM3 polymorphism rs12252-C restricts influenza A viruses.
|
25314048 |
2014 |
|
rs1129293
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
In humans, we tested the genetic association of disease severity in influenza A/H1N1pdm09-infected patients with three potentially functional <i>PIK3CG</i> single-nucleotide polymorphisms (SNPs), rs1129293, rs17847825, and rs2230460.
|
29867955 |
2018 |
|
rs121434431
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report three unrelated children with influenza A virus (IAV) infection manifesting as acute respiratory distress syndrome (IAV-ARDS), heterozygous for rare <i>TLR3</i> variants (P554S in two patients and P680L in the third) causing autosomal dominant (AD) TLR3 deficiency.
|
31217193 |
2019 |
|
rs16944
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL6 rs1818879 (GA) heterozygous genotype was associated with severe influenza A (H1N1) virus infection (odds ratio [OR] = 5.94, 95% confidence interval [CI] 3.05-11.56), and two IL1B SNPs, rs16944 AG and rs3136558 TC, were associated with a decreased risk of infection (OR = 0.52 and OR = 0.51, respectively).
|
26657940 |
2015 |
|
rs17847825
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed that SNPs rs17847825 and rs2230460 (A and T alleles, respectively) were significantly associated with protection from severe disease using the recessive model in patients infected with influenza A</span>(H1N1)pdm09.
|
29867955 |
2018 |
|
rs1800896
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL10 rs1800896 "C/A" genotype was significantly associated with fatality in influenza A/H1N1pdm09 infections.
|
30475169 |
2018 |
|
rs1801274
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Host genomic DNA was isolated from pharyngeal samples of 110 patients from northern Greece with severe (n = 59) or mild (n = 51) influenza A(H1N1)pdm09 disease, at baseline, and the genotype of CD55 rs2564978, C1QBP rs3786054 and FCGR2A rs1801274 SNPs was investigated.
|
30306260 |
2019 |
|
rs1818879
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL6 rs1818879 (GA) heterozygous genotype was associated with severe influenza A (H1N1) virus infection (odds ratio [OR] = 5.94, 95% confidence interval [CI] 3.05-11.56), and two IL1B SNPs, rs16944 AG and rs3136558 TC, were associated with a decreased risk of infection (OR = 0.52 and OR = 0.51, respectively).
|
26657940 |
2015 |
|
rs2230460
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed that SNPs rs17847825 and rs2230460 (A and T alleles, respectively) were significantly associated with protection from severe disease using the recessive model in patients infected with influenza A(H1N1)pdm09.
|
29867955 |
2018 |
|
rs2275913
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also, the absence of A allele in IL-17 rs2275913 SNP increased the risk of influenza A (H1N1) infection (P = 0.008).
|
31196204 |
2019 |
|
rs2564978
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Host genomic DNA was isolated from pharyngeal samples of 110 patients from northern Greece with severe (n = 59) or mild (n = 51) influenza A(H1N1)pdm09 disease, at baseline, and the genotype of CD55 rs2564978, C1QBP rs3786054 and FCGR2A rs1801274 SNPs was investigated.
|
30306260 |
2019 |
|
rs28454025
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course.
|
26379185 |
2015 |
|
rs3136558
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic susceptibility was determined (pA/H1N1 vs. AHC): the LTA rs909253 TC heterozygous genotype conferred greater risk (OR = 1.9), and a similar association was observed with the IL1B rs3136558 CC genotype (OR = 1.89).
|
26657940 |
2015 |
|
rs333
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Human CCR5Δ32 (rs333) polymorphism has no influence on severity and mortality of influenza A(H1N1)pdm09 infection in Brazilian patients from the post pandemic period.
|
30389547 |
2019 |
|
rs3786054
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Host genomic DNA was isolated from pharyngeal samples of 110 patients from northern Greece with severe (n = 59) or mild (n = 51) influenza A(H1N1)pdm09 disease, at baseline, and the genotype of CD55 rs2564978, C1QBP rs3786054 and FCGR2A rs1801274 SNPs was investigated.
|
30306260 |
2019 |
|
rs524991
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
A common genetic variant (rs524991, P=6.15E-08) as well as past influenza A (P=0.024) or B (P=0.006) infection were identified as predisposing factors for NMDAR-AB seropositivity.
|
23999527 |
2014 |
|
rs7629263
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
The E119D neuraminidase mutation identified in a multidrug-resistant influenza A(H1N1)pdm09 isolate severely alters viral fitness in vitro and in animal models.
|
27185624 |
2016 |
|
rs774024297
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Importantly, Mal-D96N genetic variation confers a physiological protective phenotype to in vivo models of LPS-, <i>Escherichia coli</i>-, and influenza A virus-induced hyperinflammatory disease in a gene dosage-dependent manner.
|
30787108 |
2019 |
|
rs909253
|
|
Influenza A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic susceptibility was determined (pA/H1N1 vs. AHC): the LTA rs909253 TC heterozygous genotype conferred greater risk (OR = 1.9), and a similar association was observed with the IL1B rs3136558 CC genotype (OR = 1.89).
|
26657940 |
2015 |