|
rs12936231
|
|
Asthma
|
|
0.720 |
GeneticVariation
|
BEFREE |
This study aimed to investigate whether variation in the functional 17q21 single nucleotide polymorphism rs12936231 affects the preventive potential of vitamin D against asthma.A combined secondary analysis of two randomised controlled trials of prenatal vitamin D supplementation for the prevention of asthma in offspring (Vitamin D Antenatal Asthma Reduction Trial (VDAART) and Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC<sub>2010</sub>)) was performed, stratifying by genotype and integrating metabolite data to explore underlying mechanisms.The protective effect of vitamin D on asthma/wheeze was evident among children with the low-risk rs12936231 GG genotype (hazard ratio (HR) 0.49, 95% CI 0.26-0.94, p=0.032) but not the high-risk CC genotype (HR 1.08, 95% CI 0.69-1.69, p=0.751).
|
31439681 |
2019 |
|
rs12936231
|
|
Asthma
|
|
0.720 |
GeneticVariation
|
BEFREE |
For 3 of these SNPs, we found significant interaction with smoking and asthma (rs12936231, rs2290400, and rs8079416).
|
22626592 |
2012 |
|
rs12936231
|
|
Asthma
|
|
0.720 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs11557467
|
|
Asthma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Subjects carrying the G allele of rs11557467 or the C allele of rs9303277 showed increased risk of asthma (odds ratio [OR] 1.27, 95% confidence interval 1.07-1.51, P = 0.006, and OR 1.27, 1.07-1.49, P = 0.005, respectively), even after adjusting for age and sex.
|
21985515 |
2011 |
|
rs11557467
|
|
Asthma
|
|
0.710 |
GeneticVariation
|
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs4795397
|
|
Asthma
|
A |
0.710 |
GeneticVariation
|
GWASCAT |
A meta-analysis of genome-wide association studies of asthma in Puerto Ricans.
|
28461288 |
2017 |
|
rs4795397
|
|
Asthma
|
|
0.710 |
GeneticVariation
|
BEFREE |
We found that a single nucleotide polymorphism rs4795397 influences the activity of ZPBP2 promoter in vitro in an allele-dependent fashion, and also leads to nucleosome repositioning on the asthma-associated allele.
|
22271045 |
2012 |
|
rs1054609
|
|
Primary biliary cirrhosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
rs1054609
|
|
Asthma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs10852935
|
|
Primary biliary cirrhosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
rs10852936
|
|
Allergic Reaction
|
T |
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
rs10852936
|
|
Primary biliary cirrhosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
rs11078925
|
|
Allergic Reaction
|
C |
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
rs11078925
|
|
Primary biliary cirrhosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
rs11078925
|
|
Asthma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs11557466
|
|
Allergic Reaction
|
T |
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
rs11557466
|
|
Primary biliary cirrhosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
rs11557466
|
|
Asthma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs11557467
|
|
Allergic Reaction
|
T |
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
rs11557467
|
|
Primary biliary cirrhosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
rs11557467
|
|
Primary biliary cirrhosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.
|
22936693 |
2012 |
|
rs11557467
|
|
Childhood asthma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.
|
17611496 |
2007 |
|
rs11650661
|
|
Primary biliary cirrhosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
rs11655198
|
|
Asthma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
rs11658278
|
|
Atrial Fibrillation
|
T |
0.700 |
GeneticVariation
|
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |