|
rs6561334
|
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
rs6561334
|
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
rs6561334
|
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
rs6561334
|
|
Low density lipoprotein cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Insomnia symptom of MDD was not resolved in patients with the A/A genotype of HTR2A-rs6311 when treated with SSRI.
|
31111219 |
2019 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant association was found between the SNPs analysed and response to escitalopram in patients with MDD though a significant association was seen between the side effect of memory loss and rs6311.
|
26261165 |
2015 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no significant association between FSD and the 5HT2A (rs6311) SNP in patients with MDD on SSRI therapy.
|
24533444 |
2014 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The most replicated findings are the associations between rs6295 (HTR1A gene) G allele or G/G genotype and rs6311 (HTR2A gene) A allele or A/A genotype and MD or depressive symptoms.
|
23547754 |
2013 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The purpose of this study was to determine the prevalence of female SDD, its clinical correlates and association with 5HT2A (rs6311) SNP in patients with major depressive disorder (MDD) treated with SSRIs.
|
23857836 |
2013 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the current meta-analysis indicated that the SNP rs6311 within the 5-HTR2A gene may be not associated with an increased risk for MDD, the results require further study to acquire more direct evidence.
|
23317793 |
2013 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To explore the possible relationship between six single nucleotide polymorphisms (SNPs) (rs6311 and rs6305 of 5-HT2A, rs5443 of Gβ3, rs2230739 of ACDY9, rs1549870 of PDE1A and rs255163 of CREB1, which are all related with 5-HT2A the signal transduction pathway) and the response efficacy to selective serotonin reuptake inhibitor (SSRI) treatments in major depressive disorder (MDD) Chinese.
|
22480177 |
2012 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5HT2A receptor gene (HTR2A) polymorphisms rs7997012 and rs6311 have in some earlier studies been associated with serotonin selective reuptake inhibitor (SSRI) treatment response in major depressive disorder (MDD), but the findings are inconsistent.
|
21741447 |
2011 |
|
rs6311
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population.
|
20589614 |
2010 |
|
rs6313
|
|
Unipolar Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
rs6313
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygous short (SS) genotype-HTTLPR, GG genotype of HTR2A-rs6311 and CC genotype of HTR2A-rs6313 were associated with AD treatment-induced insomnia, while val/met genotype of BDNF-rs6265 and the TT genotype of GSK-3beta-rs5443 reduced it.
|
31111219 |
2019 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To explore further, the present study aimed to assess the influence of DRD2 -141 C Ins/Del, Taq1A and HTR2A -1438 G/A, 102T/C and HTR2C -759 C/T genetic polymorphisms in response to risperidone in patients with schizophrenia.
|
30332506 |
2019 |
|
rs6313
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
rs6313
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
After all, according to these findings, -1438A/G, 102T/C, and 5-HTTLPR polymorphisms could be considered as promising pharmacogenetic biomarkers in CIT/SERT treatment in major depressive disorder (MDD) patients to avoid the occurrence of SD.
|
31792367 |
2019 |
|
rs6313
|
|
Unipolar Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder.
|
30221791 |
2018 |
|
rs6313
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder.
|
30221791 |
2018 |
|
rs6313
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant association was covered between allelic and recessive models of 5-HT2A T102C and AD (allelic model: <i>p</i> = 0.003, OR [95% CI] = 1.23 [1.07, 1.40]; recessive model: <i>p</i> = 0.03, OR [95% CI] = 1.28 [1.02, 1.59]).
|
29599928 |
2018 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that rs6311 and rs6313 polymorphisms of 5-HT<sub>2A</sub>R are not associated with schizophrenia.
|
27598719 |
2017 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three CpG sites were hypermethylated in schizophrenia (cg5 <i>p</i> = 0.028, cg7 <i>p</i> = 0.021, cg10 <i>p</i> = 0.017) and <i>HTR2A</i> polymorphisms rs6314 (<i>p</i> = 0.008) and rs6313 (<i>p</i> = 0.026) showed genetic association with schizophrenia.
|
28054990 |
2017 |
|
rs6313
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the 5HT2A T102C might be a susceptible factor for hallucinations, aberrant motor behavior, and psychosis in AD.
|
29349076 |
2017 |