Source: GWASDB

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17228212
rs17228212
SMAD3
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.810 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282

2011
dbSNP: rs17228212
rs17228212
SMAD3
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		C 0.810 GeneticVariation GWASDB The combined analysis of the two studies identified four additional loci significantly associated with coronary artery disease (P<1.3x10(-6)) and a high probability (>80%) of a true association: chromosomes 1p13.3 (rs599839), 1q41 (rs17465637), 10q11.21 (rs501120), and 15q22.33 (rs17228212). 17634449

2007
dbSNP: rs744910
rs744910
SMAD3
CUI: C0004096
Disease: Asthma
Asthma 		0.810 GeneticVariation GWASDB Genome-wide association study to identify genetic determinants of severe asthma. 22561531

2012
dbSNP: rs744910
rs744910
SMAD3
CUI: C0004096
Disease: Asthma
Asthma 		0.810 GeneticVariation GWASDB Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. 21907864

2011
dbSNP: rs744910
rs744910
SMAD3
CUI: C0004096
Disease: Asthma
Asthma 		G 0.810 GeneticVariation GWASDB We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)). 20860503

2010
dbSNP: rs12913547
rs12913547
SMAD3
CUI: C0524957
Disease: Corneal Topography
Corneal Topography 		T 0.800 GeneticVariation GWASDB Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. 23291589

2013
dbSNP: rs17228058
rs17228058
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		G 0.800 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs17293632
rs17293632
SMAD3
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		T 0.800 GeneticVariation GWASDB Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. 23128233

2012
dbSNP: rs17293632
rs17293632
SMAD3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		T 0.800 GeneticVariation GWASDB Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463

2010
dbSNP: rs17294280
rs17294280
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		G 0.800 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs16950687
rs16950687
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		G 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs17293632
rs17293632
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		T 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs1866316
rs1866316
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		C 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs2033784
rs2033784
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		G 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs2278546
rs2278546
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		G 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs35874463
rs35874463
SMAD3
CUI: C0489786
Disease: Height
Height 		0.700 GeneticVariation GWASDB Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. 21194676

2011
dbSNP: rs4562997
rs4562997
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		A 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs7173698
rs7173698
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		G 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs7174445
rs7174445
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		G 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs7181556
rs7181556
SMAD3
CUI: C0524957
Disease: Corneal Topography
Corneal Topography 		0.700 GeneticVariation GWASDB Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. 23291589

2013
dbSNP: rs8032739
rs8032739
SMAD3
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		G 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013