Source: CURATED

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3771180
rs3771180
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		T 0.820 GeneticVariation GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806

2018
dbSNP: rs3771180
rs3771180
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		0.820 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs3771180
rs3771180
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		0.820 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs10197862
rs10197862
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		A 0.810 GeneticVariation GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013

2014
dbSNP: rs10197862
rs10197862
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		0.810 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs13015714
rs13015714
IL18R1
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		C 0.810 GeneticVariation GWASCAT Newly identified genetic risk variants for celiac disease related to the immune response. 18311140

2008
dbSNP: rs13015714
rs13015714
IL18R1
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		C 0.810 GeneticVariation GWASDB Newly identified genetic risk variants for celiac disease related to the immune response. 18311140

2008
dbSNP: rs13408661
rs13408661
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		G 0.810 GeneticVariation GWASDB We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483

2012
dbSNP: rs13408661
rs13408661
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		G 0.810 GeneticVariation GWASCAT We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483

2012
dbSNP: rs13408661
rs13408661
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		0.810 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs3771166
rs3771166
IL18R1
CUI: C0004096
Disease: Asthma
Asthma 		0.810 GeneticVariation GWASDB Genome-wide association study to identify genetic determinants of severe asthma. 22561531

2012
dbSNP: rs3771166
rs3771166
IL18R1
CUI: C0004096
Disease: Asthma
Asthma 		0.810 GeneticVariation GWASDB Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. 21907864

2011
dbSNP: rs3771166
rs3771166
IL18R1
CUI: C0004096
Disease: Asthma
Asthma 		G 0.810 GeneticVariation GWASDB We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)). 20860503

2010
dbSNP: rs3771166
rs3771166
IL18R1
CUI: C0004096
Disease: Asthma
Asthma 		G 0.810 GeneticVariation GWASCAT We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)). 20860503

2010
dbSNP: rs13015714
rs13015714
IL18R1
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		G 0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. 26482879

2015
dbSNP: rs13015714
rs13015714
IL18R1
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		G 0.800 GeneticVariation GWASDB Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. 23042114

2012
dbSNP: rs13015714
rs13015714
IL18R1
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		G 0.800 GeneticVariation GWASCAT Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. 23042114

2012
dbSNP: rs1420101
rs1420101
IL18R1 ; IL1RL1
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure 		A 0.800 GeneticVariation GWASCAT Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. 19198610

2009
dbSNP: rs1420101
rs1420101
IL18R1 ; IL1RL1
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure 		A 0.800 GeneticVariation GWASDB Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. 19198610

2009
dbSNP: rs950881
rs950881
IL18R1 ; IL1RL1
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		0.800 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965

2016
dbSNP: rs950881
rs950881
IL18R1 ; IL1RL1
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		T 0.800 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569

2013
dbSNP: rs9807989
rs9807989
IL18R1
CUI: C0004096
Disease: Asthma
Asthma 		0.800 GeneticVariation GWASCAT Genome-wide association study to identify genetic determinants of severe asthma. 22561531

2012
dbSNP: rs9807989
rs9807989
IL18R1
CUI: C0004096
Disease: Asthma
Asthma 		0.800 GeneticVariation GWASDB Genome-wide association study to identify genetic determinants of severe asthma. 22561531

2012
dbSNP: rs10192157
rs10192157
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		0.710 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503

2010
dbSNP: rs1420101
rs1420101
IL18R1 ; IL1RL1
CUI: C0004096
Disease: Asthma
Asthma 		T 0.710 GeneticVariation GWASCAT Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults. 30578877

2019