Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11134527
rs11134527
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 GeneticVariation BEFREE In summary, the findings of this meta-analysis did not support an association between miR-218 rs11134527 polymorphism and cancer risk. 30120974

2018

dbSNP: rs11134527
rs11134527
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 GeneticVariation BEFREE Previous studies have reported that <i>miR-218</i> rs11134527 A>G is associated with susceptibility to various cancer risks. 29717030

2018

dbSNP: rs11134527
rs11134527
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 GeneticVariation BEFREE Previous studies have reported that <i>miR-218</i> rs11134527 A>G is associated with susceptibility to various cancer risks. 29717030

2018

dbSNP: rs11134527
rs11134527
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 GeneticVariation BEFREE In summary, the findings of this meta-analysis did not support an association between miR-218 rs11134527 polymorphism and cancer risk. 30120974

2018

dbSNP: rs11134527
rs11134527
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.040 GeneticVariation BEFREE These results indicated that rs11134527 in pri-miR-218-2 and rs531564 in pri-miR-124-1 could be associated with CIN and cervical cancer in the Chinese Han population. 29152130

2017

dbSNP: rs11134527
rs11134527
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 GeneticVariation BEFREE The findings suggest that pre-miR-218 rs11134527 polymorphism may have some relation to cancer development in Chinese. 24761857

2014

dbSNP: rs11134527
rs11134527
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 GeneticVariation BEFREE Pri-mir-218 rs11134527 and LAMB3 rs2566 were genotyped in ESCC patients and 745 controls to assess their associations with cancer risk and overall survival. 25337271

2014

dbSNP: rs11134527
rs11134527
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 GeneticVariation BEFREE Pri-mir-218 rs11134527 and LAMB3 rs2566 were genotyped in ESCC patients and 745 controls to assess their associations with cancer risk and overall survival. 25337271

2014

dbSNP: rs11134527
rs11134527
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 GeneticVariation BEFREE The findings suggest that pre-miR-218 rs11134527 polymorphism may have some relation to cancer development in Chinese. 24761857

2014

dbSNP: rs11134527
rs11134527
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.040 GeneticVariation BEFREE The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women. 23320911

2013

dbSNP: rs11134527
rs11134527
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.040 GeneticVariation BEFREE MiR-218 plays an important role in heart development in zebrafish. pri-miR-218 rs11134527 variant is associated with cervical cancer carcinogenesis. 23566829

2013

dbSNP: rs11134527
rs11134527
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.040 GeneticVariation BEFREE These findings indicate that pri-miR-218 rs11134527 and LAMB3 rs2566 may contribute to cervical cancer carcinogenesis, and further validations in diverse populations and functional characterizations are warranted. 20163849

2010

dbSNP: rs11134527
rs11134527
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.030 GeneticVariation BEFREE These results indicated that rs11134527 in pri-miR-218-2 and rs531564 in pri-miR-124-1 could be associated with CIN and cervical cancer in the Chinese Han population. 29152130

2017

dbSNP: rs11134527
rs11134527
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.030 GeneticVariation BEFREE These results indicated that rs11134527 in pri-miR-218-2 and rs531564 in pri-miR-124-1 could be associated with CIN and cervical cancer in the Chinese Han population. 29152130

2017

dbSNP: rs11134527
rs11134527
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.030 GeneticVariation BEFREE rs11134527 may be a novel genetic risk factor of HCC in HBV-exposed subjects, can facilitate HBV preS deletion generation and predispose the host to the effect of T1674C/G and preS1 start codon mutation in hepatocarcinogenesis. 24118778

2014

dbSNP: rs11134527
rs11134527
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.030 GeneticVariation BEFREE However, no significant association between the rs11134527 polymorphism and hepatocellular carcinoma risk was observed in all comparison models tested (AG vs AA: OR=0.94, 95%CI: 0.79-1.11; GG vs AA: OR=0.88, 95%CI: 0.70-1.10; GG+AG vs AA: OR=0.92, 95%CI: 0.79-1.08; GG vs AA+AG: OR=0.91, 95%CI: 0.75-1.11). 24761857

2014

dbSNP: rs11134527
rs11134527
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.030 GeneticVariation BEFREE MiR-218 plays an important role in heart development in zebrafish. pri-miR-218 rs11134527 variant is associated with cervical cancer carcinogenesis. 23566829

2013

dbSNP: rs11134527
rs11134527
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.030 GeneticVariation BEFREE MiR-218 plays an important role in heart development in zebrafish. pri-miR-218 rs11134527 variant is associated with cervical cancer carcinogenesis. 23566829

2013

dbSNP: rs11134527
rs11134527
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.030 GeneticVariation BEFREE These findings suggested that the AG genotype of pri-miR-218 rs11134527 might relate to genetic predisposition and be involved in regulating the expression of AFP in Chinese HCC patients. 22011248

2012

dbSNP: rs11134527
rs11134527
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.030 GeneticVariation BEFREE These findings indicate that pri-miR-218 rs11134527 and LAMB3 rs2566 may contribute to cervical cancer carcinogenesis, and further validations in diverse populations and functional characterizations are warranted. 20163849

2010

dbSNP: rs11134527
rs11134527
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.030 GeneticVariation BEFREE These findings indicate that pri-miR-218 rs11134527 and LAMB3 rs2566 may contribute to cervical cancer carcinogenesis, and further validations in diverse populations and functional characterizations are warranted. 20163849

2010

dbSNP: rs11134527
rs11134527
Squamous cell carcinoma of esophagus
0.020 GeneticVariation BEFREE Stratified analysis showed that rs11134527 variant significantly increased the risk of developing ESCC. 30120974

2018

dbSNP: rs11134527
rs11134527
Squamous cell carcinoma of esophagus
0.020 GeneticVariation BEFREE Although there was a significant association between rs11134527 and better survival of ESCC patients under codominant, recessive and additive models, the association disappeared after adjustment for TNM and LNM. 25337271

2014

dbSNP: rs11134527
rs11134527
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.010 GeneticVariation BEFREE Our results indicated that the A allele of rs11134527 might be a risk factor (OR=1.24; 95% CI: 1.03-1.50) and that the T allele of rs4705343 might be a protective factor (OR=0.80; 95% CI: 0.66-0.98) for NSCLC in a Han Chinese population. 29692628

2018

dbSNP: rs11134527
rs11134527
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.010 GeneticVariation BEFREE Moreover, the association analysis of these SNPs between adenocarcinoma and squamous cell carcinoma (SCC) showed that allele A of rs11134527 was associated with SCC (OR=0.65; 95% CI: 0.48-0.88). 29692628

2018