|
rs17879961
|
|
Breast Carcinoma
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs17879961
|
|
Breast Carcinoma
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
rs17879961
|
|
Breast Carcinoma
|
G |
0.900 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
CHEK2 mutations and the risk of papillary thyroid cancer.
|
25583358 |
2015 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
|
24880342 |
2014 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
In total, 26,336 cases and 44,219 controls from 18 case-control studies were used in this meta-analysis, and significant associations of the CHEK2 I157T variant with cancer susceptibility were found (OR, 1.39; 95% CI, 1.19-1.63; p<0.0001), breast cancer (OR=1.58, 95% CI=1.42-1.75, p<0.00001) and colorectal cancer (OR=1.67, 95% CI=1.24-2.26, p=0.0008).
|
23713947 |
2013 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma.
|
22811390 |
2013 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
The risk of gastric cancer in carriers of CHEK2 mutations.
|
23296741 |
2013 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
|
22419737 |
2012 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Seven thousand four hundred ninety-four BRCA1 mutation-negative patients with breast cancer and 4,346 control women were genotyped for four founder mutations in CHEK2 (del5395, IVS2+1G>A, 1100delC, and I157T).
|
21876083 |
2011 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
CHEK2 mutations and HNPCC-related colorectal cancer.
|
19876921 |
2010 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer.
|
18725978 |
2008 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Characterization of CHEK2 mutations in prostate cancer.
|
16835864 |
2006 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia.
|
16574953 |
2006 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
The I157T variant may be associated with breast cancer risk, but the risk is lower than for 1100delC.
|
15239132 |
2004 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.
|
11719428 |
2001 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
|
11298456 |
2001 |
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs17879961
|
|
Carcinoma of lung
|
A |
0.730 |
GeneticVariation
|
GWASCAT |
We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)).
|
24880342 |
2014 |
|
rs17879961
|
|
Malignant neoplasm of lung
|
A |
0.730 |
GeneticVariation
|
GWASDB |
We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)).
|
24880342 |
2014 |
|
rs17879961
|
|
Malignant neoplasm of ovary
|
G |
0.710 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs17879961
|
|
Endometrial Carcinoma
|
G |
0.710 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs17879961
|
|
Malignant tumor of colon
|
G |
0.710 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs17879961
|
|
Neoplastic Syndromes, Hereditary
|
G |
0.700 |
CausalMutation
|
CLINVAR |
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
|
26681312 |
2016 |
|
rs17879961
|
|
Neoplastic Syndromes, Hereditary
|
G |
0.700 |
CausalMutation
|
CLINVAR |
Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.
|
27153395 |
2016 |