|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the rs25489 and rs1799782 polymorphisms were associated with increased risk of HCC.
|
31478224 |
2020 |
|
rs25489
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we have further studied the interactions between these two proteins, including two variants of XRCC1 (R194W and R280H) arising from single-nucleotide polymorphisms (SNPs) that have been associated with elevated cancer risk in some reports.
|
30446622 |
2019 |
|
rs25489
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS1 (rs1805794).
|
31584889 |
2019 |
|
rs25489
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS1 (rs1805794).
|
31584889 |
2019 |
|
rs25489
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we have further studied the interactions between these two proteins, including two variants of XRCC1 (R194W and R280H) arising from single-nucleotide polymorphisms (SNPs) that have been associated with elevated cancer risk in some reports.
|
30446622 |
2019 |
|
rs25489
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS1 (rs1805794).
|
31584889 |
2019 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, there was no association between Arg194Trp or Arg280His and the risk of HCC.
|
30408066 |
2018 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no association between the risk of HCC development and the XRCC1 Arg280His or XRCC1 Arg399Gln genotypes.
|
29935355 |
2018 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In overall analyses, the minor alleles of four variants, Arg280His (odds ratio, 95% confidence interval, P: 1.37, 1.13-1.66, 0.001), Thr241Met (1.93, 1.17-3.20, 0.011), Asp312Asn (1.22, 1.08-1.38, 0.001) and Lys751Gln (1.42, 1.02-1.97, 0.038), were associated with the significant risk for hepatocellular carcinoma.
|
27306318 |
2016 |
|
rs25489
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the four polymorphisms that were previously studied, only rs25489 of XRCC1 was significantly associated with lung cancer risk (dominant model, adjusted odds ratio = 0.61, 95% confidence interval = 0.46-0.83, P = 0.002).
|
25592768 |
2015 |
|
rs25489
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Despite accumulating evidence of an important role that XRCC1 plays in maintaining genomic stability, the relationship between one of its most predominant variants, R280H (rs25489), and cancer prevalence remains ambiguous.
|
26011397 |
2015 |
|
rs25489
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA repair genes is a key factor for cancer susceptibility, and we conducted a case-control study to investigate the association of XRCC1 codons 194 (Arg to Trp), 280 (Arg to His) and 399 (Arg to Gln) with risk of NSCLC.
|
26097609 |
2015 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our analysis suggests that the XRCC1 Arg280His polymorphism is associated with a higher risk of HCC.
|
26125922 |
2015 |
|
rs25489
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Despite accumulating evidence of an important role that XRCC1 plays in maintaining genomic stability, the relationship between one of its most predominant variants, R280H (rs25489), and cancer prevalence remains ambiguous.
|
26011397 |
2015 |
|
rs25489
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the four polymorphisms that were previously studied, only rs25489 of XRCC1 was significantly associated with lung cancer risk (dominant model, adjusted odds ratio = 0.61, 95% confidence interval = 0.46-0.83, P = 0.002).
|
25592768 |
2015 |
|
rs25489
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the four polymorphisms that were previously studied, only rs25489 of XRCC1 was significantly associated with lung cancer risk (dominant model, adjusted odds ratio = 0.61, 95% confidence interval = 0.46-0.83, P = 0.002).
|
25592768 |
2015 |
|
rs25489
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA repair genes is a key factor for cancer susceptibility, and we conducted a case-control study to investigate the association of XRCC1 codons 194 (Arg to Trp), 280 (Arg to His) and 399 (Arg to Gln) with risk of NSCLC.
|
26097609 |
2015 |
|
rs25489
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |
|
rs25489
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |
|
rs25489
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms of the DNA repair gene X-ray repair cross-complementing protein 1 (XRCC1) Arg194Trp, Arg280His, and Arg399Gln have been shown to alter the DNA repair activity and to be associated with genetic susceptibility to several types of cancer.
|
23425027 |
2013 |
|
rs25489
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms of the DNA repair gene X-ray repair cross-complementing protein 1 (XRCC1) Arg194Trp, Arg280His, and Arg399Gln have been shown to alter the DNA repair activity and to be associated with genetic susceptibility to several types of cancer.
|
23425027 |
2013 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
No evidence of association of Arg194Trp (980 HCC cases and 966 controls) and Arg280His (1,200 HCC cases and 1,236 controls) with HCC risk was found.
|
23055199 |
2013 |
|
rs25489
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hence, we performed a meta-analysis to investigate the association between lung cancer risk and XRCC1 Arg399Gln (14,156 cases and 16,667 controls from 41 studies), Arg194Trp (7,426 cases and 9,603 controls from 23 studies), Arg280His (6,211 cases and 6,763 controls from 16 studies), -77T>C (2,487 cases and 2,576 controls from 5 studies), and XRCC3 T241M (8,560 cases and 11,557 controls from 19 studies) in different inheritance models.
|
23990873 |
2013 |
|
rs25489
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The XRCC1 Arg280His gene polymorphism and hepatocellular carcinoma risk: a meta-analysis.
|
23679314 |
2013 |
|
rs25489
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hence, we performed a meta-analysis to investigate the association between lung cancer risk and XRCC1 Arg399Gln (14,156 cases and 16,667 controls from 41 studies), Arg194Trp (7,426 cases and 9,603 controls from 23 studies), Arg280His (6,211 cases and 6,763 controls from 16 studies), -77T>C (2,487 cases and 2,576 controls from 5 studies), and XRCC3 T241M (8,560 cases and 11,557 controls from 19 studies) in different inheritance models.
|
23990873 |
2013 |