Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 GeneticVariation BEFREE A total of 37 patients with non-small cell lung cancer (NSCLC) were selected to determine the expression levels of miR-608; 96 NSCLC patients and 136 cancer-free healthy controls were recruited to determine the incidence of miR-608 rs4919510 in lung cancer patients. 31552102

2019
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 GeneticVariation BEFREE A total of 37 patients with non-small cell lung cancer (NSCLC) were selected to determine the expression levels of miR-608; 96 NSCLC patients and 136 cancer-free healthy controls were recruited to determine the incidence of miR-608 rs4919510 in lung cancer patients. 31552102

2019
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.050 GeneticVariation BEFREE A total of 37 patients with non-small cell lung cancer (NSCLC) were selected to determine the expression levels of miR-608; 96 NSCLC patients and 136 cancer-free healthy controls were recruited to determine the incidence of miR-608 rs4919510 in lung cancer patients. 31552102

2019
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation BEFREE Thus, the present study explored the association between five common functional polymorphisms in miRNAs (i.e., miRNA-196a2C>T, rs11614913; miRNA-146aG>C, rs2910164; miRNA-423C>A, rs6505162; miRNA-608G>C, rs4919510; miRNA-27aC>T, rs895819) and the risk of BC. 29782194

2018
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 GeneticVariation BEFREE The meta-analysis suggested that the microRNA-608 rs4919510 polymorphism maybe associate with a significantly decreased risk for colorectal cancer. 29909406

2018
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 GeneticVariation BEFREE Thus, the present study explored the association between five common functional polymorphisms in miRNAs (i.e., miRNA-196a2C>T, rs11614913; miRNA-146aG>C, rs2910164; miRNA-423C>A, rs6505162; miRNA-608G>C, rs4919510; miRNA-27aC>T, rs895819) and the risk of BC. 29782194

2018
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 GeneticVariation BEFREE Moreover, the RegulomeDB database indicated that rs4919510 may affect the expression of two nearby genes ( SEMA4G and MRPL43), and the Cancer Genome Atlas database revealed that the expression level of SEMA4G was significantly lower in colorectal cancer and lung cancer tissues than that in adjacent non-tumour tissues, while the expression level of SEMA4G was significantly higher in gastric cancer tissues than that in adjacent non-tumour tissues. 28653886

2017
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation BEFREE In the present meta-analysis, no relationships between miR-608 rs4919510 polymorphism (C>G) and the risk of breast cancer were found. 28829821

2017
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.050 GeneticVariation BEFREE Moreover, the RegulomeDB database indicated that rs4919510 may affect the expression of two nearby genes ( SEMA4G and MRPL43), and the Cancer Genome Atlas database revealed that the expression level of SEMA4G was significantly lower in colorectal cancer and lung cancer tissues than that in adjacent non-tumour tissues, while the expression level of SEMA4G was significantly higher in gastric cancer tissues than that in adjacent non-tumour tissues. 28653886

2017
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 GeneticVariation BEFREE Moreover, the RegulomeDB database indicated that rs4919510 may affect the expression of two nearby genes ( SEMA4G and MRPL43), and the Cancer Genome Atlas database revealed that the expression level of SEMA4G was significantly lower in colorectal cancer and lung cancer tissues than that in adjacent non-tumour tissues, while the expression level of SEMA4G was significantly higher in gastric cancer tissues than that in adjacent non-tumour tissues. 28653886

2017
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 GeneticVariation BEFREE Moreover, the RegulomeDB database indicated that rs4919510 may affect the expression of two nearby genes ( SEMA4G and MRPL43), and the Cancer Genome Atlas database revealed that the expression level of SEMA4G was significantly lower in colorectal cancer and lung cancer tissues than that in adjacent non-tumour tissues, while the expression level of SEMA4G was significantly higher in gastric cancer tissues than that in adjacent non-tumour tissues. 28653886

2017
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 GeneticVariation BEFREE In the present meta-analysis, no relationships between miR-608 rs4919510 polymorphism (C>G) and the risk of breast cancer were found. 28829821

2017
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.050 GeneticVariation BEFREE However, miR-196a2 rs11614913, miR-30c-1 rs928508, miR-608 rs4919510 and miR-27a rs895819 polymorphisms were not significantly associated with lung cancer risks in any models. 26973201

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 GeneticVariation BEFREE Conflicting results are available on the association between rs4919510, a SNP in mature miR-608 and clinical outcome in CRC. 27381831

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation BEFREE In contrast, the miR-499 (rs3746444) AG/GG genotypes were associated with an increased risk of BC (OR = 1.45, 95% CI = 1.10-1.91), and miR-608 (rs4919510) was not significantly associated with BC risk. 26886638

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 GeneticVariation BEFREE However, miR-196a2 rs11614913, miR-30c-1 rs928508, miR-608 rs4919510 and miR-27a rs895819 polymorphisms were not significantly associated with lung cancer risks in any models. 26973201

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 GeneticVariation BEFREE However, miR-196a2 rs11614913, miR-30c-1 rs928508, miR-608 rs4919510 and miR-27a rs895819 polymorphisms were not significantly associated with lung cancer risks in any models. 26973201

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation BEFREE Our data do not support an association of rs11614913:C > T and rs4919510:C > G with BC risk. 27421647

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.050 GeneticVariation BEFREE Our results showed that rs3746444 in mir-499 (allele C vs T: OR = 1.33; 95% CI = 1.15-1.54; P = 1.2 × 10-4) and rs4919510 in mir-608 (allele G vs C: OR = 1.27; 95% CI= 1.13-1.43; P = 5.1 × 10-5) were significantly associated with increased risk of lung cancer. 27232940

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 GeneticVariation BEFREE Our data do not support an association of rs11614913:C > T and rs4919510:C > G with BC risk. 27421647

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 GeneticVariation BEFREE Our results showed that rs3746444 in mir-499 (allele C vs T: OR = 1.33; 95% CI = 1.15-1.54; P = 1.2 × 10-4) and rs4919510 in mir-608 (allele G vs C: OR = 1.27; 95% CI= 1.13-1.43; P = 5.1 × 10-5) were significantly associated with increased risk of lung cancer. 27232940

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 GeneticVariation BEFREE In contrast, the miR-499 (rs3746444) AG/GG genotypes were associated with an increased risk of BC (OR = 1.45, 95% CI = 1.10-1.91), and miR-608 (rs4919510) was not significantly associated with BC risk. 26886638

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 GeneticVariation BEFREE Our results showed that rs3746444 in mir-499 (allele C vs T: OR = 1.33; 95% CI = 1.15-1.54; P = 1.2 × 10-4) and rs4919510 in mir-608 (allele G vs C: OR = 1.27; 95% CI= 1.13-1.43; P = 5.1 × 10-5) were significantly associated with increased risk of lung cancer. 27232940

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 GeneticVariation BEFREE The results showed that rs4919510</span> was significantly associated with a decreased susceptibility to CRC in co-dominant, allele and recessive genetic models, and the protective role of rs4919510 allele G and genotype GG was more pronounced among stage 0-II cases; significant association between rs531564 and poor RFS was observed in cases undergoing adjuvant chemo-radiotherapy in co-dominant, allele and dominant models; moreover, there was a positive association between rs7372209 and recurrence-free survival in stage II cases in co-dominant and over-dominant models; additionally, a cumulative effect of rs531564 and rs7372209 at-risk genotypes with hazard ratio at 1.30 and 1.95 for one and two at-risk genotypes was examined in stage II cases, respectively. 27713147

2016
dbSNP: rs4919510
rs4919510
SEMA4G ; MRPL43 ; MIR608
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 GeneticVariation BEFREE The individuals with both risk genotypes of miRNA SNPs and exposure to risk factor (cooking oil fumes) were in a higher risk of lung cancer than persons with only one of the two risk factors (ORs were 1.91, 1.05 and 1.41 for miR-146a rs2910164, ORs were 1.94, 1.23 and 1.34 for miR-196a2 rs11614913, ORs were 2.06, 1.41 and 1.68 for miR-608 rs4919510, ORs were 1.76, 0.82 and 1.07 for miR-27a rs895819, and ORs were 2.13, 1.15 and 1.02 for miR-423 rs6505162, respectively). 26083623

2015