When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.
When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.
A cluster of 12 SNPs on 12q24 were found to significantly (P<5×10(-8)) associate with drinking behavior in stage 1, among which rs671 (a Glu-to-Lys substitution at position 504) in the ALDH2 gene showed the strongest association (odds ratio (OR)=0.16, P=3.6×10(-211) in the joint analysis).
Notably, by an integrated analysis of the genotypes and the serum levels of APOA5, BUD13 and triglyceride, we observed that BUD13 was another potential mediator, besides APOA5, of the association between rs651821 and serum triglyceride. rs671 (ALDH2), an east Asian-specific common variant, was found to be associated with MetS (P<sub>combined</sub> = 9.7 × 10<sup>-22</sup> ) in Han Chinese.
Moreover, 9 missense variants were newly identified, of which we identified new associations between a common population-specific missense variant, rs671 (p.Glu457Lys) of ALDH2, and two traits including aspartate aminotransferase (P = 5.20 × 10<sup>-13</sup>) and alanine aminotransferase (P = 4.98 × 10<sup>-8</sup>).
"ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample."
"ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample."
"ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample."