Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4986790
rs4986790
TLR4
CUI: C0030920
Disease: Peptic Ulcer
Peptic Ulcer 		0.030 GeneticVariation BEFREE There was no significant difference in TLR4 + 3725 G/C and Asp299Gly genotype frequencies between non-peptic ulcer (NPUD) and peptic ulcer (PUD) individuals in the context of peptic ulcer development and susceptibility to infection with H. pylori. 29135054

2018
dbSNP: rs4986790
rs4986790
TLR4
CUI: C0030920
Disease: Peptic Ulcer
Peptic Ulcer 		0.030 GeneticVariation BEFREE No significant differences were found among the PU, AS, and NHS groups regarding the genetic differences at rs4986790 in the TLR4 gene. 29755012

2018
dbSNP: rs4986790
rs4986790
TLR4
CUI: C0030920
Disease: Peptic Ulcer
Peptic Ulcer 		0.030 GeneticVariation BEFREE We observed that the individuals harboring heterozygous and homozygous polymorphic variants of TLR4 conferred a significant risk to develop chronic H. pylori infection and peptic ulcer disease [rs4986790 AG, p=0.001, OR-2.7, 95%CI: 1.5-5.03; GG, p=0.0006, OR-9.8, 95%CI: 2.4-39.4; rs4986791CT, p=0.0001, OR-7.2, 95%CI: 3.7-7.2; TT, p=0.0001, OR-7.9, 95%CI: 2.6-23.7]. 27993530

2017