|
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
We have found a trend toward an association of rs1143627, rs16944, rs1143623 in IL1B gene with the risk of schizophrenia.
|
28083609 |
2016 |
|
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
Moreover, our meta-analysis results showed no significant association between the common SNV, rs16944, and schizophrenia.
|
24155145 |
2014 |
|
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present study examined the effects of a functional polymorphism at IL1B gene promoter (-511C/T; rs16944) on brain correlates of working memory performance in schizophrenia.
|
22763186 |
2012 |
|
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032).
|
21843369 |
2011 |
|
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
The combined allele-wise odds ratio (OR) for schizophrenia of the rs16944 (IL1B gene; T-511C) polymorphism was 0.86 (95% CI: 0.77to 0.96).When applying stratified analysis to this polymorphism, the pooled allele-wise OR was 0.88 (95% CI, 0.79 to 0.97) in 10 population-based studies and 0.85 (95% CI: 0.73 to 0.99) in Caucasian samples.
|
20347268 |
2010 |
|
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, meta-analysis of our data combined with previously published association studies of rs16944 (IL1beta -511) suggests that the C allele confers modest risk for schizophrenia among individuals reporting Caucasian ancestry, but not Asians (Caucasians, n=819 cases, 1292 controls; p=0.0013, OR=1.24, 95% CI 1.09, 1.41).
|
16905295 |
2006 |
|
rs1143623
|
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have found a trend toward an association of rs1143627, rs16944, rs1143623 in IL1B gene with the risk of schizophrenia.
|
28083609 |
2016 |
|
rs1143627
|
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also performed haplotype analysis of IL1 gene complex and found a trend toward an association with schizophrenia of GAGG haplotype (rs1143627, rs16944, rs1143623, rs4848306) in IL1B gene, haplotypes: TG (rs315952, rs9005) and TT (rs4251961, rs419598) in IL1RN.
|
28083609 |
2016 |
|
rs1143630
|
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Five tagging polymorphisms of IL-1β gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were examined for association with schizophrenia.
|
21843369 |
2011 |
|
rs1143633
|
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study shows the first evidence that the IL-1β gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population.
|
21843369 |
2011 |