rs11540652
|
|
Sarcoma
|
T |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
rs1042522
|
|
Sarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The mutation status of TP53 and expression of MDM2, TP53, and their genetic variants SNP309 and R72P (Arg72Pro) were investigated in 125 sarcoma patient samples and 18 sarcoma cell lines.
|
23165797 |
2013 |
rs1042522
|
|
Sarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis.
|
22205265 |
2012 |
rs1131691014
|
|
Sarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The mutation status of TP53 and expression of MDM2, TP53, and their genetic variants SNP309 and R72P (Arg72Pro) were investigated in 125 sarcoma patient samples and 18 sarcoma cell lines.
|
23165797 |
2013 |
rs1131691014
|
|
Sarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis.
|
22205265 |
2012 |
rs762846821
|
|
Sarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, using FSF-Kras(G12D/+); p53(FRT/FRT) mice, we demonstrate that an adenovirus expressing FlpO recombinase can initiate primary lung cancers and sarcomas in mice. p53(FRT) mice will enable dual recombinase technology to study cancer biology because Cre is available to modify genes specifically in stromal cells to investigate their role in tumor development, progression and response to therapy.
|
22228755 |
2012 |
rs762846821
|
|
Sarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results suggest that genomic alterations present in human MFH are conserved in the LSL-Kras(G12D); p53(Flox/Flox) mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model.
|
19956606 |
2009 |
rs878854066
|
|
Sarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The mutation status of TP53 and expression of MDM2, TP53, and their genetic variants SNP309 and R72P (Arg72Pro) were investigated in 125 sarcoma patient samples and 18 sarcoma cell lines.
|
23165797 |
2013 |
rs878854066
|
|
Sarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis.
|
22205265 |
2012 |
rs1057519747
|
|
Sarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Approximately 50% of the ovarian tumors in p53(wt/wt) mice and 23% in p53(Ala135Val/wt) mice are adenocarcinomas and the remaining tumors were adenocarcinoma mixed with sarcoma or ovarian sarcomas.
|
18234966 |
2008 |
rs1057519975
|
|
Sarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using three viral constructs containing cDNA for wild-type p53, mutant p53 (C135S) and lacZ, we studied the effect of adenoviral-mediated gene therapy in four pediatric sarcoma cell lines, RD and Rh4 (RMS), Rh1 (Ewing's sarcoma) and A204 (undifferentiated sarcoma).
|
15618970 |
2005 |
rs121912665
|
|
Sarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Approximately 50% of the ovarian tumors in p53(wt/wt) mice and 23% in p53(Ala135Val/wt) mice are adenocarcinomas and the remaining tumors were adenocarcinoma mixed with sarcoma or ovarian sarcomas.
|
18234966 |
2008 |