|
rs2075291
|
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
A genetic variant c.553G > T (rs2075291) in the apolipoprotein A5 gene is associated with altered triglycerides levels in coronary artery disease (CAD) patients with lipid lowering drug.
|
30606120 |
2019 |
|
rs2075291
|
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
We identified a missense SNP, rs2075291, in APOA5 associated with CAD</span> at a genome-wide significance level and provided new insights into pathways contributing to the susceptibility to CAD in the multi-ethnic populations from Southeast Asia.
|
29263402 |
2017 |
|
rs2075291
|
|
Coronary Artery Disease
|
A |
0.720 |
GeneticVariation
|
GWASCAT |
We identified a missense SNP (rs2075291, G > T, G185C) in APOA5 for CAD that reached robust genome-wide significance (Meta P = 7.09 × 10<sup>-10</sup>, OR = 1.636).
|
29263402 |
2017 |
|
rs651821
|
|
Coronary Artery Disease
|
T |
0.710 |
GeneticVariation
|
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
rs651821
|
|
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
<i>APOA5</i> SNPs rs662799 and rs651821 exhibited significant differences in genotype and allele distributions between patients with CAD and control subjects.
|
29866721 |
2018 |
|
rs662799
|
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |
|
rs662799
|
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
<i>APOA5</i> SNPs rs662799 and rs651821 exhibited significant differences in genotype and allele distributions between patients with CAD and control subjects.
|
29866721 |
2018 |
|
rs662799
|
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women.
|
27716220 |
2016 |
|
rs662799
|
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis.
|
26309253 |
2015 |
|
rs662799
|
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
CAD association was replicated and/or verified for 4 loci: SORT1 rs611917 (p=1.7 × 10(-8)), APOA5 rs662799 (p=0.0014), LDLR rs1433099 (p=2.1 × 10(-7)), and APOE rs7412 (p=6.1 × 10(-13)).
|
23050023 |
2012 |
|
rs662799
|
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Polymerase chain reaction-based genotyping of PON1 Q192R (rs662) and APOA5-1131T>C (rs662799) polymorphism was carried out in 520 individuals, including 250 CAD patients (160 with T2DM and 90 without T2DM), 150 T2DM patients with no identified CAD, and 120 normal healthy sex- and age-matched individuals as controls.
|
21438666 |
2011 |
|
rs662799
|
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
We assessed the -1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride concentration, several other risk factors, and risk of coronary heart disease.
|
20452521 |
2010 |
|
rs3135506
|
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Mediation analysis yielded a mediation effect of p.S19W on risk of premature CAD through HDL-C (OR = 0.98, P = 0.040) and TG (OR = 0.98, P = 0.042), suggesting a causal relationship between p.S19W and premature CAD partially through its effects on HDL-C and TG levels.
|
30024021 |
2018 |
|
rs3135506
|
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
The genetic variants of rs3135506 (G), rs10455872 (A) and rs3798220 (G) have low frequency in our population and reflected no association with CAD.
|
29309886 |
2018 |
|
rs3135506
|
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
From these data, we conclude that (1) APOA5 p.S19W is a common variant, with very few additional APOA5 gene mutations; (2) APOA5 p.S19W plays a major role in triglyceride metabolism; and (3) APOA5 p.S19W is a CAD risk factor.
|
22914599 |
2012 |
|
rs3135506
|
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Therefore, the present study aimed to elucidate the relationship of four single nucleotide polymorphisms (SNPs) in the Apo11q cluster, namely the -75G>A, +83C>T SNPs in the APOA1 gene, the Sac1 SNP in the APOC3 gene and the S19W variant in the APOA5 gene to plasma lipids and CAD in 190 affected sibling pairs (ASPs) belonging to Asian Indian families with a strong CAD history.
|
18801202 |
2008 |
|
rs3135506
|
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Nine hundred and thirteen angiografically defined patients (669 CAD and 244 CAD-free) were genotyped for APOA5 -1131 C>T and S19W polymorphisms.
|
16682041 |
2007 |
|
rs2266788
|
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The polymorphic variants of Apo-A5; rs2266788 (C), 9p21.3; rs1333049 (C) rs2383207 (A) are associated with CAD, its severity and exerts the risk of MI in North Indian population.
|
29309886 |
2018 |
|
rs2266788
|
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Of note, gene dosage of rs2266788 demonstrated a robust association with triglyceride level (p = 1.39 × 10(-19)), modified Gensini scores (p = 1.67 × 10(-3)), and numbers of vascular lesions in CAD patients (odds ratio: 1.96, 95% confidence interval: 1.31 to 2.14, p = 8.96 × 10(-4)).
|
25034063 |
2014 |