rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A non-synonymous polymorphism (R325W) in its gene is associated with Type-2 diabetes.
|
30710592 |
2019 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The current study demonstrated a modest but significant effect of SLC30A8 (rs13266634) polymorphisms on T2D predisposition.
|
31823921 |
2019 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A specific genetic variant, rs13266634 (c.973C>T; p.ARG325TRP) in zinc transporter SLC30A8/ZnT8, is associated with protection against Type-2 Diabetes, suggesting it may be actionable for predicting and preventing POHG.
|
31220282 |
2019 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A common variant W325R in the C-terminal domain (CTD) increases the risk to develop type 2 diabetes and affects autoantibody specificity in type 1 diabetes.
|
29430817 |
2018 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A total of 556 healthy controls and 413 T2DM patients were genotyped for ZnT8 Arg325Trp polymorphism confirming the association of Arg-325 variant with an increased T2DM risk (OR = 1.35 95% C.I: 1.10-1.66; p = 0.0044).
|
30142362 |
2018 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
<b>Conclusion:</b> The present meta-analysis demonstrated that <i>SLC30A8</i> rs13266634 was a potential risk factor for T2DM, and more studies should be performed to confirm the association between rs13266634 polymorphism and IGR.
|
30319545 |
2018 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2).
|
28738793 |
2017 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The non-synonymous single nucleotide polymorphism (SNP) rs13266634 in human zinc transporter 8, ZnT8 (SLC30A8), leads to a R325 variant, which is associated with an increased risk of developing Type 2 Diabetes (T2D).
|
28965566 |
2017 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
ZnT8 null mice have a mild phenotype with a slight decrease in glucose tolerance, whereas patients with the ZnT8 R325W polymorphism (rs13266634) have decreased proinsulin staining and susceptibility to T2DM.
|
27899481 |
2017 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (<i>TCF7L2</i> rs7901695, <i>FTO</i> rs8050136, <i>HHEX</i> rs5015480, <i>SLC30A8</i> rs13266634 and <i>IGF2BP2</i> rs4402960) were observed in this study population.
|
28067832 |
2017 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The solute carrier family 30 member 8 gene (<i>SLC30A8</i>) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in <i>SLC30A8</i> is associated with an increased risk of type 2 diabetes (T2D).
|
29093761 |
2017 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The R325W C-allele were more frequent in women with GDM compared to in controls (OR 1.47, 95 % CI 1.16-1.88, p = 0.0018) but not significantly increased in women with GDM and postpartum development of type 2 diabetes.
|
27003436 |
2016 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
We confirm the association of TCF7L2 (rs7903146) and SLC30A8 (rs13266634) with T2D.
|
27310578 |
2016 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on T2DM in an African population when stratified by ethnicity under additive model even with a small number of studies.
|
26832344 |
2016 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
We assessed the interaction between type 2 diabetes-associated SLC30A8 rs13266634 and gestational weight gain on 1-5 years of postpartum glycemic changes in 1,071 women with prior GDM in a longitudinal study.
|
27600066 |
2016 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
We estimate that the rs13266634 single nucleotide polymorphism, a type 2 diabetes susceptibility genotype, has a genetic prevalence of 56.3%, 47.4% and 37.0% in Mexican Mestizo, Caucasian, and Asian populations.
|
25875676 |
2015 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our results suggest that rs13266634 may be an important genetic factor of type 2 diabetes risk among Asian and European but not African populations.
|
26214053 |
2015 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D.
|
25839936 |
2015 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
SLC30A8 encodes a zinc transporter in the beta cell; individuals with a common missense variant (rs13266634; R325W) in SLC30A8 demonstrate a lower early insulin response to glucose and an increased risk of type 2 diabetes.
|
25348609 |
2015 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Gene-environment interaction analysis showed a significant interaction between rs13266634</span> in SLC30A8 gene and age on T2DM risk (P<0.0001).
|
24736664 |
2014 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
We observed an association between allele variants of SLC30A8 [rs13266634 (C/T)] and type 2-diabetes (P = 0.04).
|
25501231 |
2014 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05].
|
24993573 |
2014 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our study suggested that the C allele of rs13266634 was associated with higher odds of T2D, and higher plasma zinc was associated with lower odds.
|
24306209 |
2014 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The variant rs13266634 in SLC30A8, encoding a β-cell-specific zinc transporter, is associated with type 2 diabetes.
|
24471563 |
2014 |
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Thus, the present study aimed to investigate the association between rs13266634 polymorphism and T2DM in Fars province, Southern Iran and compare the results with other populations.
|
24449369 |
2014 |