Variant Gene Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Our results show that T45G and G276T polymorphisms of ADPN are associated with a significantly elevated risk of DPN in T2DM patients, likely by down-regulating ADPN serum level. 26144281

2016

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses. 25135112

2015

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE These data suggest that the GG genotype at rs2241766 is implicated in the pathogenesis of risk for diabetic nephropathy defined as UACR greater than 30 mg/day in patients with T2DM. 23260797

2013

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes. 21638131

2012

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only. 22497971

2012

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Adiponectin gene polymorphism 45T>G is associated with carotid artery plaques in patients with type 2 diabetes mellitus. 18191060

2008

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects. 15842511

2005

dbSNP: rs266729
rs266729
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE The polymorphism of rs266729 in adiponectin gene and type 2 diabetes mellitus: A Meta-Analysis. 29381968

2018

dbSNP: rs266729
rs266729
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE However, G vs C allele of -11377C>G (rs266729) might be a risk factor for type 2 diabetes. 21638131

2012

dbSNP: rs266729
rs266729
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only. 22497971

2012

dbSNP: rs266729
rs266729
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis. 20580771

2010

dbSNP: rs266729
rs266729
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE On the contrary, -11377C/G (rs266729) was associated with type 2 diabetes in the obese group only (OR=2.45, 95%CI: 1.13-5.31, P=0.02), and 59% risk of diabesity could be attributed to that. 19359061

2009

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses. 25135112

2015

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE Rs2241766 and rs1501299 of ADIPOQ were genotyped in 708 patients with T2DM. 23260797

2013

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE Recessive protective effect of ADIPOQ rs1501299 on cardiovascular diseases with type 2 diabetes: a meta-analysis. 22040602

2012

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes. 21638131

2012

dbSNP: rs1063539
rs1063539
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE In the case-control analysis, PPARG rs1801282 (Pro12Ala) (OR=1.48 (1.02-2.16)), ADIPOQ rs1063539 (OR=1.17 (1.01-1.35)), and HNF4A rs1884614 (OR=1.16 (1.00-1.32) were associated with T2D (P(allelic)<0.05). 22515931

2013

dbSNP: rs1063539
rs1063539
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE Among these mutations, the 4545G/C mutation (rs1063539) contributed to the genetic risk of T2D in the non-obese group (OR=2.34, 95%CI: 1.31-4.21, P=0.004), and 57% of the risk is related to this polymorphism. 19359061

2009

dbSNP: rs16861194
rs16861194
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE When T2D cohort was further stratified according to the obesity status, PPARγ2 (rs1801282) and FTO (rs9939609) showed association with T2D only in the obese diabetic group and ADIPOQ (rs16861194) showed no difference in risk of susceptibility to the disease. 26243686

2016

dbSNP: rs16861194
rs16861194
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only. 22497971

2012

dbSNP: rs17300539
rs17300539
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes. 21638131

2012

dbSNP: rs17300539
rs17300539
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only. 22497971

2012

dbSNP: rs182052
rs182052
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE In addition, 2-site haplotype analysis in the ADIPOQ locus using only 2 marginally associated SNPs (AD/rs182052 and AD/rs7649121) revealed a significant protective association of the GA haplotype with T2D (P = .009, permutation P = .026). 19846176

2010

dbSNP: rs182052
rs182052
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE The SNP rs182052 in intron 1 of the adiponectin gene is associated with type 2 diabetes in African Americans. 19056609

2009

dbSNP: rs1063538
rs1063538
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only. 22497971

2012