Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913250
rs121913250
NRAS
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 GeneticVariation BEFREE KRAS c.34G>A mutation was detected in primary tumor and liver metastasis, which additionally revealed 2 rare PI3KCA mutations (c.1633G>C and c.1645G>C). 29409955

2018
dbSNP: rs121913250
rs121913250
NRAS
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 GeneticVariation BEFREE KRAS exon 2 mutation variants were associated with heterogeneous outcome compared with unmutated tumors with KRAS G12C and G13D (trend) being associated with rather poor survival. 27358379

2016
dbSNP: rs121913250
rs121913250
NRAS
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 GeneticVariation BEFREE Since hypoxic microenvironments select for tumor cells with diminished therapeutic response, we investigated whether hypoxia unequally increases resistance to 3-BrPA in wt p53 MelJuso melanoma harbouring (Q61L)-mutant NRAS and wt BRAF, C8161 melanoma with (G12D)-mutant KRAS (G464E)-mutant BRAF, and A549 lung carcinoma with a KRAS (G12S)-mutation. 27863474

2016
dbSNP: rs121913250
rs121913250
NRAS
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 GeneticVariation BEFREE One tumor harbored a missense mutation in the c-Kit (p.F504L) and in the KRAS gene (p.G12S). 21131919

2011