|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
FTO gene rs9939609 polymorphism is significantly more prevalent among Sri Lankan PCOS subjects while the other selected SNPs of HPG axis genes and INSR gene showed no association.
|
30596735 |
2018 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs9939609 variation of FTO gene is significantly associated with risk of PCOS.
|
28451524 |
2017 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, subgroup analysis in Asian and Caucasian ethnicities also found significant association between rs9939609 </span>A/T polymorphism and PCOS (In Asian subgroup: OR = 1.43, 95% CI = 1.29-1.59, P < 0.0001.
|
28826396 |
2017 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicate that neither the FTO rs9939609 and rs8050136 polymorphisms nor its haplotypes are related to PCOS, but suggest an association between the presence of risk alleles of SNPs rs9939609 and rs8050136 in FTO and glucose levels in women from Southern Brazil.
|
25592819 |
2015 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association found between PCOS and FTO rs9939609 (p=0.0302) was attenuated after adjustment for BMI (p=0.187).
|
26032905 |
2015 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our present meta-analysis indicated that FTO rs9939609 polymorphism (or its proxy) might not be associated with risk of PCOS in overall population.
|
24466303 |
2014 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
FTO rs9939609 was not a major determinant of PCOS.
|
25086788 |
2014 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variant rs9939609 in FTO is associated with PCOS in Chinese women, not only in obese PCOS subjects, but also in non-obese cases.
|
23840863 |
2013 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Seven studies describing eight distinct PCOS cohorts were retrieved; seven were genotyped for SNP rs9939609 and one for SNP rs1421085.
|
22801903 |
2012 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In PCOS the observed per risk allele effect of FTO intron 1 SNP rs9939609 on BMI was +1.56 kg/m2, whereas it was +0.46 kg/m2 in females of the same age range from the general population as shown previously.
|
20092643 |
2010 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped the single nucleotide polymorphism rs9939609 (T/A) in 288 PCOS women and performed metabolic and hormonal measurements, oral glucose tolerance test, hirsutism score, and lipometry.
|
19913856 |
2010 |
|
rs9939609
|
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusions, the rs9939609 variant in the FTO gene is associated with PCOS susceptibility in the Chinese population, probably because of its effect on BMI.
|
19859840 |
2009 |