|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, whether the influence of rs1625579 on schizophrenia in the Asian population is consistent with these results remains unclear.
|
31586698 |
2019 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Taken together, rs1625579 seems to play an important role in both functional and structural connectivity between the PCC and the ACC/MPFC, which may serve as the brain mechanisms for the link between rs1625579 and schizophrenia.
|
30035013 |
2018 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Schizophrenia patients with the MIR137 rs1625579 risk genotype (homozygous for the schizophrenia risk variant) also have aberrant brain structure.
|
28958479 |
2018 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Polymorphisms of the rs1625579 locus in the <i>miR-13</i> gene are associated with schizophrenia susceptibility, and high glucose-induced upregulation of miR-137 in vascular endothelial cells promotes monocyte chemotaxis and inflammatory cytokine secretion in gestational diabetes mellitus.
|
30122962 |
2018 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
<i>MIR137</i> rs1625579 polymorphism might be an important sex-dependent factor influencing severity of schizophrenia psychopathological manifestations.
|
30026708 |
2018 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three SNPs (rs1625579, rs1344706 and rs4765905) showed a consistent direction of effect with previous studies and the polygenic risk score constructed using the weighted sum of these three SNPs showed a significant association with Schizophrenia in this population (OR=3.78, p=0.005).
|
29599094 |
2018 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Gene interaction analysis showed that MIR137 SNP rs1625579 did not affect schizophrenia susceptibility in interaction with the CPLX1 polymorphic variants.
|
29118371 |
2017 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates that the rs1625579 miR-137 genetic variant significantly increases schizophrenia risk.
|
27706734 |
2016 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that the SNP rs1625579 in miR-137 gene might be involved in schizophrenia susceptibility in Chinese Han population.
|
27095331 |
2016 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We could not confirm the significant association of rs1625579 with schizophrenia in Asian samples, which may have resulted from potential genetic heterogeneity on this locus between continental populations.
|
27096222 |
2016 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genetic influence of the rs2660304 proxy SNP on the transcriptional activity of the internal MIR137 promoter, and thus the levels of miR-137 expression, therefore offers a distinct regulatory mechanism to explain the functional significance of the rs1625579 GWAS SNP for schizophrenia risk.
|
26429811 |
2016 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The most robust finding has been reported for rs1625579 located in MIR137HG, which was associated with schizophrenia on a genome-wide level.
|
25395183 |
2015 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, a meta-analysis indicated that the 'T' allele of SNP rs1625579 was not associated with susceptibility to SCZ in Han Chinese populations (pooled OR 1.087, 95 % CI 0.847-1.396, P = 0.512).
|
25241074 |
2015 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia.
|
26123324 |
2015 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
MIR137 has been identified as a candidate gene for schizophrenia from genome-wide association studies via association with an intronic single nucleotide polymorphism (SNP), rs1625579.
|
25154622 |
2015 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Specifically, SCZ carrying the risk TT genotype had worse negative symptoms and decreased FA in the fronto-striatal regions compared to G and A allele carriers for rs1625579 and rs1198588 respectively, and worse attention and processing speed compared with G-allele for rs1625579.
|
25921703 |
2015 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The miR-137 schizophrenia susceptibility variant rs1625579 does not predict variability in brain volume in a sample of schizophrenic patients and healthy individuals.
|
25044277 |
2014 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
By grouping 81 healthy participants as carrier or non-carriers of the MIR137 rs1625579 risk allele associated with schizophrenia, we investigated MIR137's effects on altered cortical response during an fMRI face processing task and altered functional connectivity using the amygdala as a seed region.
|
24361663 |
2014 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the meta-analysis, we observed a significant association between rs1625579</span> and sch</span>izophrenia under different genetic models (all P < 0.05).
|
25250332 |
2014 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP rs1625579) within the micro-RNA 137 (MIR137) gene recently achieved strong genome-wide association with schizophrenia (SZ).
|
24820543 |
2014 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study suggests that the rs1625579 TT (miR-137 locus) schizophrenia risk genotype is associated with the schizophrenia risk phenotype DLPFC hyperactivation commonly considered a measure of brain inefficiency.
|
23910899 |
2014 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, decreased miR-137 expression is associated with the SZ risk allele of rs1625579, and potential regulation of TCF4, another SZ candidate gene.
|
23786914 |
2013 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped 821 patients with confirmed DSM-IV diagnoses of schizophrenia, bipolar affective disorder I and schizoaffective disorder for the risk SNP (rs1625579) and investigated the clinical profiles of risk allele carriers using a within-case design.
|
22982201 |
2013 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We examined the influence of the genome-wide significant schizophrenia risk variant rs1625579 near the microRNA (miRNA)-137 (MIR137) gene on well-established sources of phenotypic variability in schizophrenia: age-at-onset of psychosis and brain structure.
|
23459466 |
2013 |
|
rs1625579
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We examined three groups of individuals performing a sentence completion paradigm: (i) individuals at high genetic risk of SCZ (n=44), (ii) individuals at high genetic risk of BD (n=90), and (iii) healthy controls (n=81) in order to test the hypothesis that genotype at rs1625579 would influence brain activation.
|
22850735 |
2012 |