DisGeNET - a database of gene-disease associations

Source: GWASDB

Disease: Bilirubin measurement ×

Gene: UGT1A8 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs10178992

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs10178992

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs10179091

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

23371916

2013

dbSNP:

rs10179091

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs10179091

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs10179091

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

19419973

2009

dbSNP:

rs10929301

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3 ; LOC100286922

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs10929301

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3 ; LOC100286922

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs10929302

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3 ; LOC100286922

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

In addition, SNP rs10929302 located in phenobarbital response enhancer module was significantly associated with bilirubin level with a P-value of 1.37 × 10(-11); this enhancer module is believed to have a critical role in phenobarbital treatment of hyperbilirubinemia.

22085899

2012

dbSNP:

rs11673726

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3 ; LOC100286922

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs11673726

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3 ; LOC100286922

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs11695484

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3 ; DNAJB3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

23371916

2013

dbSNP:

rs11695484

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3 ; DNAJB3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs11888459

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A2P ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs11888459

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A2P ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs11891311

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

23371916

2013

dbSNP:

rs11891311

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

23642732

2013

dbSNP:

rs11891311

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs11891311

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

19419973

2009

dbSNP:

rs12988520

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A9

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs17862875

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A3

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs17863787

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A9

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs1875263

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs1875263

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs2070959

UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A9

CUI:	C0344395
Disease:	Bilirubin measurement

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

23642732

2013