Source: INFERRED ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 221 0.236 0.962 0.53 0.900 None 1.000 0 0 1993 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 85 0.300 0.885 0.39 0.800 None 1.000 0 0 1996 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 382 0.320 0.923 7.9E-04 0.700 None 0.974 0 0 1997 2019
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		Q13485 SMAD family member 4 Transcription factor 190 0.401 0.808 1.00 0.700 None 1.000 0 0 1999 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 218 0.379 0.846 2.4E-25 0.650 None 0.857 0 0 2003 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		P38398 BRCA1 DNA repair associated Enzyme 170 0.367 0.923 9.2E-29 0.620 None 1.000 0 0 2005 2015
Entrez Id: 6794
Gene Symbol: STK11
STK11 		Q15831 serine/threonine kinase 11 Kinase 72 0.435 0.808 0.99 0.610 None 1.000 1 1 2004 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 341 0.305 0.923 0.26 0.440 None 1.000 0 0 2002 2018
Entrez Id: 7015
Gene Symbol: TERT
TERT 		O14746 telomerase reverse transcriptase Enzyme 142 0.374 0.846 0.99 0.440 None 1.000 0 0 2004 2015
Entrez Id: 324
Gene Symbol: APC
APC 		P25054 APC regulator of WNT signaling pathway 187 0.373 0.962 1.00 0.430 None 1.000 0 0 2002 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		Q86YC2 partner and localizer of BRCA2 173 0.485 0.769 3.0E-19 0.420 None 1.000 0 0 2011 2015
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1 		P00995 serine peptidase inhibitor Kazal type 1 44 0.492 0.808 0.31 0.410 None 1.000 0 0 2003 2009
Entrez Id: 8314
Gene Symbol: BAP1
BAP1 		Q92560 BRCA1 associated protein 1 Enzyme 43 0.454 0.731 0.99 0.410 None 1.000 0 0 2014 2015
Entrez Id: 7249
Gene Symbol: TSC2
TSC2 		P49815 TSC complex subunit 2 Enzyme modulator 105 0.439 0.808 1.00 0.410 None 1.000 0 0 2005 2010
Entrez Id: 7490
Gene Symbol: WT1
WT1 		P19544 WT1 transcription factor Nucleic acid binding 151 0.422 0.808 1.00 0.400 None 1.000 0 0 2009 2009
Entrez Id: 1019
Gene Symbol: CDK4
CDK4 		P11802 cyclin dependent kinase 4 Kinase 24 0.412 0.808 6.3E-02 0.300 None 1.000 0 0 2012 2012
Entrez Id: 5888
Gene Symbol: RAD51
RAD51 		Q06609 RAD51 recombinase 137 0.447 0.846 2.7E-02 0.300 None 1.000 0 0 2010 2010
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		P24385 cyclin D1 Enzyme modulator 62 0.344 0.923 0.89 0.130 None 1.000 0 0 1996 2013
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A 		P10644 protein kinase cAMP-dependent type I regulatory subunit alpha 217 0.401 0.846 1.00 0.120 None 1.000 0 0 2011 2017
Entrez Id: 7428
Gene Symbol: VHL
VHL 		P40337 von Hippel-Lindau tumor suppressor Enzyme 112 0.443 0.846 8.0E-02 0.120 None 1.000 0 0 2005 2010
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		Q00987 MDM2 proto-oncogene Nucleic acid binding 17 0.362 0.846 1.00 0.120 None 1.000 0 0 2009 2014
Entrez Id: 2313
Gene Symbol: FLI1
FLI1 		Q01543 Fli-1 proto-oncogene, ETS transcription factor Transcription factor 134 0.468 0.692 0.99 0.110 None 1.000 0 0 2016 2016
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B 		P42772 cyclin dependent kinase inhibitor 2B 54 0.417 0.769 7.3E-03 0.110 None 1.000 0 0 1996 1996
Entrez Id: 4255
Gene Symbol: MGMT
MGMT 		P16455 O-6-methylguanine-DNA methyltransferase 20 0.412 0.885 1.2E-07 0.110 None 1.000 0 0 2009 2009
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		O96017 checkpoint kinase 2 Kinase 79 0.460 0.808 1.2E-24 0.110 None 1.000 0 0 2006 2006