Source: CLINVAR ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 22 0.300 0.885 0.39 0.700 None 0.949 1 7 1995 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 125 0.319 0.846 1.00 0.500 None 0.979 1 12 2003 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 84 0.236 0.962 0.53 0.500 None 0.963 1 38 1994 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT 		P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 21 0.366 0.808 0.98 0.500 None 1.000 1 2 2009 2020
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		P01111 NRAS proto-oncogene, GTPase Enzyme modulator 37 0.390 0.808 0.49 0.500 None 0.967 1 6 2001 2020
Entrez Id: 1019
Gene Symbol: CDK4
CDK4 		P11802 cyclin dependent kinase 4 Kinase 7 0.412 0.808 6.3E-02 0.500 None 1.000 1 2 1999 2016
Entrez Id: 5879
Gene Symbol: RAC1
RAC1 		P63000 Rac family small GTPase 1 Enzyme modulator 5 0.429 0.962 0.76 0.440 None 1.000 1 2 2014 2019
Entrez Id: 5894
Gene Symbol: RAF1
RAF1 		P04049 Raf-1 proto-oncogene, serine/threonine kinase Kinase 45 0.418 0.885 0.85 0.440 None 1.000 1 1 2005 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 107 0.305 0.923 0.26 0.440 None 1.000 1 2 2000 2016
Entrez Id: 2767
Gene Symbol: GNA11
GNA11 		P29992 G protein subunit alpha 11 Enzyme modulator 5 0.563 0.731 0.89 0.430 None 1.000 1 1 2014 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 70 0.303 0.885 1.00 0.430 None 1.000 1 10 2001 2017
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 71 0.378 0.885 8.0E-02 0.420 None 1.000 1 7 2013 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 85 0.292 0.923 1.00 0.410 None 1.000 1 11 2006 2016
Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2 		P36507 mitogen-activated protein kinase kinase 2 Kinase 8 0.534 0.731 0.97 0.410 None 1.000 1 2 2013 2016
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1 		Q02750 mitogen-activated protein kinase kinase 1 Kinase 26 0.439 0.846 0.90 0.400 None 1.000 1 6 2016 2016
Entrez Id: 5537
Gene Symbol: PPP6C
PPP6C 		O00743 protein phosphatase 6 catalytic subunit 2 0.729 0.231 0.86 0.400 None 1.000 1 1 2016 2016
Entrez Id: 23451
Gene Symbol: SF3B1
SF3B1 		O75533 splicing factor 3b subunit 1 Nucleic acid binding 8 0.511 0.731 1.00 0.140 None 1.000 1 3 2013 2020
Entrez Id: 2146
Gene Symbol: EZH2
EZH2 		Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 6 0.376 0.885 1.00 0.140 None 1.000 1 3 2015 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 66 0.320 0.923 7.9E-04 0.120 None 1.000 1 2 2001 2016
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 23 0.328 0.923 6.0E-03 0.110 None 0.500 1 3 2001 2016
Entrez Id: 9125
Gene Symbol: CNOT9
CNOT9 		Q92600 CCR4-NOT transcription complex subunit 9 5 0.769 0.192 0.99 0.110 None 1.000 1 4 2015 2016
Entrez Id: 567
Gene Symbol: B2M
B2M 		P61769 beta-2-microglobulin Immune response 12 0.447 0.846 0.56 0.100 None 1.000 1 3 2016 2016
Entrez Id: 83596
Gene Symbol: BCL2L12
BCL2L12 		Q9HB09 BCL2 like 12 2 0.606 0.654 3.8E-09 0.100 None 1.000 1 1 2016 2016
Entrez Id: 8859
Gene Symbol: STK19
STK19 		P49842 serine/threonine kinase 19 2 0.691 0.500 6.7E-09 0.100 None 1.000 1 1 2016 2016
Entrez Id: 90417
Gene Symbol: KNSTRN
KNSTRN 		Q9Y448 kinetochore localized astrin (SPAG5) binding protein 2 0.729 0.500 2.1E-06 0.100 None 1.000 1 1 2016 2016