Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 351
Gene Symbol: APP
APP
P05067 amyloid beta precursor protein enzyme modulator 371 0.430 0.862 6.2E-02 0.400 0.939 83 8 1993 2018
Entrez Id: 1756
Gene Symbol: DMD
DMD
P11532 dystrophin 299 0.477 0.724 1.00 0.160 1.000 6 0 1995 2013
Entrez Id: 6334
Gene Symbol: SCN8A
SCN8A
Q9UQD0 sodium voltage-gated channel alpha subunit 8 transporter 168 0.557 0.552 1.00 0.130 0.333 3 0 2006 2016
Entrez Id: 207
Gene Symbol: AKT1
AKT1
P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 760 0.355 0.862 0.98 0.130 1.000 3 0 2011 2013
Entrez Id: 3643
Gene Symbol: INSR
INSR
P06213 insulin receptor 338 0.459 0.724 2.0E-05 0.120 1.000 2 0 2006 2013
Entrez Id: 355
Gene Symbol: FAS
FAS
P25445 Fas cell surface death receptor 490 0.393 0.862 0.84 0.120 1.000 2 0 2007 2014
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
P42345 mechanistic target of rapamycin kinase kinase; nucleic acid binding; transferase 466 0.399 0.793 1.00 0.120 1.000 2 0 2014 2015
Entrez Id: 4128
Gene Symbol: MAOA
MAOA
P21397 monoamine oxidase A nucleic acid binding; oxidoreductase; transferase 196 0.497 0.655 1.00 0.120 1.000 2 0 1998 2016
Entrez Id: 339453
Gene Symbol: TMEM240
TMEM240
Q5SV17 transmembrane protein 240 37 0.735 0.172 0.23 0.120 1.000 2 0 2014 2017
Entrez Id: 80208
Gene Symbol: SPG11
SPG11
Q96JI7 SPG11, spatacsin vesicle trafficking associated 107 0.586 0.483 6.3E-39 0.120 1.000 2 0 2008 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.110 1.000 1 0 2009 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.110 1.000 1 0 2013 2013
Entrez Id: 6712
Gene Symbol: SPTBN2
SPTBN2
O15020 spectrin beta, non-erythrocytic 2 61 0.648 0.483 3.0E-05 0.110 1.000 1 0 2013 2013
Entrez Id: 79738
Gene Symbol: BBS10
BBS10
Q8TAM1 Bardet-Biedl syndrome 10 42 0.676 0.414 2.0E-12 0.110 1.000 1 0 2016 2016
Entrez Id: 120
Gene Symbol: ADD3
ADD3
Q9UEY8 adducin 3 cytoskeletal protein 38 0.659 0.483 1.00 0.110 1.000 1 0 2010 2010
Entrez Id: 57165
Gene Symbol: GJC2
GJC2
Q5T442 gap junction protein gamma 2 cell junction protein 90 0.619 0.517 1.0E-02 0.110 1.000 1 0 2014 2014
Entrez Id: 4774
Gene Symbol: NFIA
NFIA
Q12857 nuclear factor I A nucleic acid binding; transcription factor 67 0.633 0.621 1.00 0.110 1.000 1 0 2014 2014
Entrez Id: 166379
Gene Symbol: BBS12
BBS12
Q6ZW61 Bardet-Biedl syndrome 12 33 0.696 0.414 2.0E-07 0.110 1.000 1 0 2016 2016
Entrez Id: 80347
Gene Symbol: COASY
COASY
Q13057 Coenzyme A synthase kinase; transferase 66 0.621 0.448 1.4E-09 0.110 1.000 1 0 2010 2010
Entrez Id: 3920
Gene Symbol: LAMP2
LAMP2
P13473 lysosomal associated membrane protein 2 membrane traffic protein 90 0.604 0.517 0.30 0.110 1.000 1 0 2018 2018
Entrez Id: 84197
Gene Symbol: POMK
POMK
Q9H5K3 protein-O-mannose kinase 101 0.616 0.414 2.5E-08 0.110 1.000 1 0 2015 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
P02649 apolipoprotein E 770 0.352 0.931 1.7E-03 0.100 0.906 288 2 1995 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
P23560 brain derived neurotrophic factor signaling molecule 591 0.382 0.828 0.70 0.100 0.971 35 4 2006 2017
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
P10636 microtubule associated protein tau 265 0.492 0.724 7.3E-03 0.100 0.920 25 3 2002 2018
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
Q13753 laminin subunit gamma 2 enzyme modulator; extracellular matrix protein; receptor 400 0.419 0.931 3.6E-12 0.100 1.000 20 0 2000 2016