Source: ALL
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		P38398 BRCA1 DNA repair associated Enzyme 747 0.367 0.923 9.2E-29 0.400 None 0.970 134 3 1994 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 656 0.379 0.846 2.4E-25 0.100 None 0.918 49 0 1995 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2494 0.236 0.962 0.53 0.100 None 1.000 28 5 1994 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		P03372 estrogen receptor 1 Nuclear receptor 1101 0.324 0.962 1.00 0.100 None 0.947 19 2 1997 2019
Entrez Id: 472
Gene Symbol: ATM
ATM 		Q13315 ATM serine/threonine kinase Kinase 684 0.374 0.885 5.6E-47 0.100 None 1.000 10 0 1996 2014
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		Q92731 estrogen receptor 2 Nuclear receptor 528 0.400 0.923 4.5E-08 0.080 None 1.000 8 2 2005 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 995 0.328 0.923 6.0E-03 0.060 None 1.000 6 0 2003 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 1349 0.305 0.923 0.26 0.050 None 0.800 5 0 1999 2016
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		O96017 checkpoint kinase 2 Kinase 297 0.460 0.808 1.2E-24 0.050 None 1.000 5 0 2007 2018
Entrez Id: 2272
Gene Symbol: FHIT
FHIT 		P49789 fragile histidine triad diadenosine triphosphatase 337 0.444 0.846 5.7E-03 0.050 None 1.000 5 0 1996 2010
Entrez Id: 56946
Gene Symbol: EMSY
EMSY 		Q7Z589 EMSY transcriptional repressor, BRCA2 interacting 52 0.628 0.423 1.00 0.040 None 1.000 4 0 2004 2016
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1 		P09488 glutathione S-transferase mu 1 627 0.380 0.923 2.1E-03 0.040 None 1.000 4 0 2000 2010
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2 		P21802 fibroblast growth factor receptor 2 Kinase 731 0.380 0.808 1.00 0.040 None 1.000 4 1 2009 2014
Entrez Id: 7421
Gene Symbol: VDR
VDR 		P11473 vitamin D receptor Nuclear receptor 852 0.352 0.885 1.7E-05 0.040 None 1.000 4 3 1999 2017
Entrez Id: 2177
Gene Symbol: FANCD2
FANCD2 		Q9BXW9 FA complementation group D2 272 0.479 0.885 1.1E-30 0.040 None 1.000 4 1 2006 2019
Entrez Id: 5888
Gene Symbol: RAD51
RAD51 		Q06609 RAD51 recombinase 363 0.447 0.846 2.7E-02 0.040 None 1.000 4 0 2007 2017
Entrez Id: 6794
Gene Symbol: STK11
STK11 		Q15831 serine/threonine kinase 11 Kinase 372 0.435 0.808 0.99 0.040 None 0.750 4 0 1998 2006
Entrez Id: 142
Gene Symbol: PARP1
PARP1 		P09874 poly(ADP-ribose) polymerase 1 565 0.389 0.923 3.3E-04 0.040 None 1.000 4 0 2012 2016
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		P15692 vascular endothelial growth factor A Signaling 1899 0.266 0.923 2.4E-05 0.040 None 1.000 4 0 2008 2014
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1 		P18887 X-ray repair cross complementing 1 410 0.421 0.923 6.3E-09 0.040 None 1.000 4 2 2007 2015
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 526 0.399 0.808 3.4E-05 0.030 None 1.000 3 0 1999 2005
Entrez Id: 3479
Gene Symbol: IGF1
IGF1 		P05019 insulin like growth factor 1 1206 0.318 0.885 0.27 0.030 None 1.000 3 0 2007 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		P42898 methylenetetrahydrofolate reductase 985 0.337 0.885 3.2E-10 0.030 None 1.000 3 2 2004 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		Q86YC2 partner and localizer of BRCA2 260 0.485 0.769 3.0E-19 0.030 None 0.667 3 0 2012 2017
Entrez Id: 3014
Gene Symbol: H2AX
H2AX 		P16104 H2A.X variant histone Nucleic acid binding 212 0.484 0.808 0.18 0.030 None 1.000 3 2 2008 2011