Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
0.300 Biomarker disease CTD_human Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice. 23090186 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease CTD_human Effect of age receptor blocker and/or anti-inflammatory coadministration in relation to glycation, oxidative stress and cytokine production in stz diabetic rats. 12123627 2002
Entrez Id: 6364
Gene Symbol: CCL20
CCL20
0.300 Therapeutic disease CTD_human Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 21340626 2011
Entrez Id: 3651
Gene Symbol: PDX1
PDX1
0.300 Biomarker disease CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366 2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.300 Therapeutic disease CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
0.300 Biomarker disease CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366 2005
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.300 Biomarker disease CTD_human Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis. 22138235 2012
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.300 Biomarker disease CTD_human Neuropeptidergic characterization of the leptin receptor mutated obese Koletsky rat. 15093691 2004
Entrez Id: 598
Gene Symbol: BCL2L1
BCL2L1
0.300 Biomarker disease CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
0.300 Biomarker disease CTD_human Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. 19478208 2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease CTD_human Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. 22191573 2012
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
0.300 Biomarker disease CTD_human Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium. 18266981 2008
Entrez Id: 5213
Gene Symbol: PFKM
PFKM
0.300 Biomarker disease CTD_human Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. 14563825 2004
Entrez Id: 53637
Gene Symbol: S1PR5
S1PR5
0.300 Biomarker disease CTD_human S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition. 22406263 2012
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.300 Biomarker disease CTD_human Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications. 14977883 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.300 Biomarker disease CTD_human Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. 21414306 2011
Entrez Id: 355
Gene Symbol: FAS
FAS
0.300 Biomarker disease CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366 2005
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.300 Biomarker disease CTD_human Effects of angiotensin II on insulin receptor binding and mRNA levels in normal and diabetic rats. 9243097 1997
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.300 Biomarker disease CTD_human Octaphlorethol A, a marine algae product, exhibits antidiabetic effects in type 2 diabetic mice by activating AMP-activated protein kinase and upregulating the expression of glucose transporter 4. 26939912 2016
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.300 Biomarker disease CTD_human Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice. 22933112 2012
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.300 Biomarker disease CTD_human Effects of losartan, HO-1 inducers or HO-1 inhibitors on erectile signaling in diabetic rats. 19804535 2009
Entrez Id: 1374
Gene Symbol: CPT1A
CPT1A
0.300 Biomarker disease CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366 2005
Entrez Id: 847
Gene Symbol: CAT
CAT
0.300 Biomarker disease CTD_human Effect of age receptor blocker and/or anti-inflammatory coadministration in relation to glycation, oxidative stress and cytokine production in stz diabetic rats. 12123627 2002
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.300 Biomarker disease CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease CTD_human PPARγ activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice. 21757225 2011