Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE β-Elemene attenuates atherosclerosis in apolipoprotein E-deficient mice via restoring NO levels and alleviating oxidative stress. 28962084 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Curcumin Protects against Atherosclerosis in Apolipoprotein E-Knockout Mice by Inhibiting Toll-like Receptor 4 Expression. 29224353 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE DBZ (Danshensu Bingpian Zhi), a Novel Natural Compound Derivative, Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice. 28971954 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Chemokine binding protein 'M3' limits atherosclerosis in apolipoprotein E-/- mice. 28282403 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice. 28760743 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE An atherosclerosis model was established by placing a perivascular collar on the right common carotid artery in apolipoprotein E-deficient (ApoE(-/-)) mice. 27846838 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase. 28351769 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis. 28249002 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Pravastatin attenuates the action of the ETS domain-containing protein ELK1 to prevent atherosclerosis in apolipoprotein E-knockout mice via modulation of extracellular signal-regulated kinase 1/2 signal pathway. 27998006 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Our results show that carrier women of the ApoE4 isoform are more likely to have elevated levels of LDL-C and therefore increased risk of developing atherosclerosis. 25601895 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE PEP-1-MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice. 26410585 2016
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 Biomarker disease BEFREE The aim of this study is to evaluate the relationship of miR-21, nitric oxide (NOx) and endothelial nitric oxide synthase (eNOS) with subclinical atherosclerosis in carotid arteries by measuring carotid intima media thickness (CIMT) in patients with hypertension and healthy controls. 26114349 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1). 25572313 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Cognitive scores and atherosclerosis measures were not impacted by ApoE4 status (p ≥ .455). 25957568 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice. 26104863 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Finally, EGCG inhibited high-fat diet (HFD)-induced atherosclerosis in apolipoprotein E (ApoE) knockout (ApoE-KO) mice through the Jagged-1/Notch pathway. 26648562 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE To study the role of endothelial HIF-1α in atherosclerosis, deletion of the Hif1a gene was induced in ECs from apolipoprotein E knockout mice (EC-Hif1a(-/-)) by Tamoxifen injection. 26483345 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Deletion of the gene of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in apolipoprotein E-deficient (ApoE-/-) mice increased atherosclerosis. 26900933 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 AlteredExpression disease BEFREE Loss of peroxisome proliferator-activated receptor (PPAR)-γ function in the vascular endothelium enhances atherosclerosis and NF-κB target gene expression in high-fat diet-fed apolipoprotein E-deficient mice. 26566726 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 AlteredExpression disease BEFREE Here, we show that reduced endothelial expression of the RNAse Dicer, which generates almost all mature miRNAs, decreases monocyte adhesion, endothelial C-X-C motif chemokine 1 (CXCL1) expression, atherosclerosis and the lesional macrophage content in apolipoprotein E knockout mice (Apoe(-/-)) after exposure to a high-fat diet. 26837267 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE In this study, we investigated the effects of COS treatment on atherosclerosis (AS) in apolipoprotein E deficient mice (apoE-/-). 25843117 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE In the present study, we aimed to explore the role of CRY1 in regulating atherosclerosis in apolipoprotein E (ApoE)-deficient mice and the underlying molecular mechanism. 26218278 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice. 25270622 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 AlteredExpression disease BEFREE CCL22/Macrophage-derived Chemokine Expression in Apolipoprotein E-deficient Mice and Effects of Histamine in the Setting of Atherosclerosis. 25492567 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE ATRQβ-001 vaccine prevents atherosclerosis in apolipoprotein E-null mice. 26771341 2016