Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.060 AlteredExpression disease BEFREE We find that MUC16 and p120ctn are aberrantly overexpressed in 94 clinical OC samples compared with benign ovarian tumors (BOT). 30795761 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.060 Biomarker disease BEFREE In conclusion, the selected SPs in combination with CA125 show profound promise for discriminating EOCs from BOTs and for predicting the progression after surgery, which provides invaluable information for clinicians in the precision diagnosis and treatment of EOC. 30114318 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.060 Biomarker disease BEFREE In conclusion, combinations of the markers RDW, MPV, and CA125 may improve the differential diagnosis of ovarian cancer and benign ovarian tumors. 29357908 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.060 Biomarker disease BEFREE In this study we investigated plasma levels of selected metalloproteinase and its tissue inhibitor in comparison to plasma levels of the commonly accepted tumor markers (CA 125 and HE4) in selected histological types of epithelial ovarian cancer patients as compared to control groups: patients with a benign ovarian tumor and healthy subjects. 28662671 2017
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.060 Biomarker disease BEFREE Proteomic analysis of serum of women with elevated Ca-125 to differentiate malignant from benign ovarian tumors. 22994745 2012
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.060 Biomarker disease BEFREE CA125 serum values were strikingly increased in ovarian carcinoma (median 264.16 IU/ml, normal range 0-35) and benign ovarian tumors (median 119.59 IU/ml; p <0.05). 17436409 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.050 GeneticVariation disease BEFREE In our study, we analyzed 80 benign ovarian tumors for TP53 and K-ras mutations and for LOH on chromosomes 6, 7, 9, 11 and 17 using 56 microsatellite markers. 12712441 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.050 GeneticVariation disease BEFREE To determine whether genetic abnormalities present in primary ovarian tumors can be used to detect cancer cells in peritoneal fluid, we tested 14 ovarian cancers and 1 benign tumor of the ovary for loss of heterozygosity (LOH) at chromosomal arms 13q, 17p, 17q, and 22q and for mutations in the p53 and K-ras genes. 12861058 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.050 GeneticVariation disease BEFREE In addition, a point mutation in codon 157 of TP53 was detected in one tumour which is the first report of a TP53 mutation in a solitary benign ovarian tumour. 9366520 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.050 GeneticVariation disease BEFREE Our results indicate that this tumor suppressor gene may be involved in tumorigenesis, as its expression was detected in both borderline and malignant tumors while normal ovaries and benign ovarian tumors were unstained with the p53 antibody. 8206402 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.050 GeneticVariation disease BEFREE A high frequency of p53 mutations in ovarian cancers and lack of mutation in 6 benign ovarian tumors and 2 normal ovaries suggested that the mutation of the p53 gene was associated with the genesis and/or progression of ovarian cancer. 1333465 1992
Entrez Id: 346389
Gene Symbol: MACC1
MACC1
0.020 Biomarker disease BEFREE <b>Results</b> The expressions of miR-338-3p and MACC1 gene in epithelial ovarian cancer tissues were (0.331±0.038) and (0.774±0.025), significant differences were noted between epithelial ovarian cancer and normal ovarian tissues, benign ovarian tumors (F=77.916, <i>P</i>=1.205E-18; F=77.945, <i>P</i>=1.187E-18). 31031848 2019
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.020 AlteredExpression disease BEFREE Preoperative serum carbohydrate antigen (CA)-125, CA-15-3, and nestin levels were significantly higher in the malignant group compared to patients with benign ovarian tumors (P < 0.001, respectively). 27995729 2017
Entrez Id: 346389
Gene Symbol: MACC1
MACC1
0.020 AlteredExpression disease BEFREE Levels of VM, ALDH1, and MACC1 were significantly higher, and levels of KiSS-1 significantly lower, in EOC tissues than in benign ovary tumors. 28253891 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.020 Biomarker disease BEFREE BRCA1 showed hypomethylation in 30 normal ovarian and 30 benign ovarian tumors, but showed hypermethylation or methylation in ovarian cancer patients. 23006047 2013
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.020 Biomarker disease BEFREE In our study, we validated the accuracy of methylation specific polymerase chain reaction (MSP) to analyze the methylation pattern of BRCA1, RASSF1A and ER in 59 and 10 Vietnamese patients with epithelial ovarian cancer (EOC) and benign ovarian tumors, respectively. 24460357 2013
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.020 AlteredExpression disease BEFREE Serum level of CA 15-3 was increased in patients with ovarian carcinoma (median 48.33 U/ml, normal range 0-36), while it was normal in patients with benign ovarian tumors (median 20.67 U/ml; p >0.05). 17436409 2007
Entrez Id: 80010
Gene Symbol: RMI1
RMI1
0.010 Biomarker disease BEFREE The area under the curve (AUC) of receiver operator characteristic curves (ROC) and performance indices of RMI I, RMI II, RMI III and RMI IV were calculated and compared for discrimination between benign ovarian tumors and BOTs. 31526390 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.010 AlteredExpression disease BEFREE Here, we investigated the distribution patterns of γδ T cells and their main subsets in peripheral blood and tumor tissues among OC patients, benign ovarian tumor (BOT) patients, and age-matched healthy controls (HC) by flow cytometry, as well as the expression levels of IFN-γ and IL-17A secreted from γδ T cells. 31064389 2019
Entrez Id: 1500
Gene Symbol: CTNND1
CTNND1
0.010 AlteredExpression disease BEFREE We find that MUC16 and p120ctn are aberrantly overexpressed in 94 clinical OC samples compared with benign ovarian tumors (BOT). 30795761 2019
Entrez Id: 442906
Gene Symbol: MIR338
MIR338
0.010 AlteredExpression disease BEFREE <b>Results</b> The expressions of miR-338-3p and MACC1 gene in epithelial ovarian cancer tissues were (0.331±0.038) and (0.774±0.025), significant differences were noted between epithelial ovarian cancer and normal ovarian tissues, benign ovarian tumors (F=77.916, <i>P</i>=1.205E-18; F=77.945, <i>P</i>=1.187E-18). 31031848 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.010 AlteredExpression disease BEFREE Here, we investigated the distribution patterns of γδ T cells and their main subsets in peripheral blood and tumor tissues among OC patients, benign ovarian tumor (BOT) patients, and age-matched healthy controls (HC) by flow cytometry, as well as the expression levels of IFN-γ and IL-17A secreted from γδ T cells. 31064389 2019
Entrez Id: 9148
Gene Symbol: NEURL1
NEURL1
0.010 Biomarker disease BEFREE In the discovery step we screened 441 proteins in plasma using the proximity extension assay (PEA) and five Olink Multiplex assays (CVD II, CVD III, INF I, ONC II, NEU I) in women with ovarian cancer (n = 106), endometrial cancer (n = 74), benign ovarian tumors (n = 150) and healthy population controls (n = 399). 30519148 2018
Entrez Id: 4758
Gene Symbol: NEU1
NEU1
0.010 Biomarker disease BEFREE In the discovery step we screened 441 proteins in plasma using the proximity extension assay (PEA) and five Olink Multiplex assays (CVD II, CVD III, INF I, ONC II, NEU I) in women with ovarian cancer (n = 106), endometrial cancer (n = 74), benign ovarian tumors (n = 150) and healthy population controls (n = 399). 30519148 2018
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.010 AlteredExpression disease BEFREE (1) FOLR1 protein expression was lowest in normal ovarian tissue, higher in benign ovarian tumors, and highest in malignant tumors (P < 0.01). 29433550 2018