Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases. 27569446 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE We investigated effects of fish-oil supplementation on both classical and novel markers of endothelial function in subjects prospectively genotyped for the Asp298 endothelial nitric oxide synthase (eNOS) polymorphism and at moderate risk of cardiovascular disease (CVD). 25332321 2015
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 Biomarker group BEFREE Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. 25034973 2015
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Endothelial nitric oxide synthase gene polymorphisms in cardiovascular disease. 25189395 2015
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE It had been proved that the NOS3 polymorphism (rs1799983) was associated with the development of cardiovascular diseases. 23922896 2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 AlteredExpression group BEFREE In contrast, level of eNOS protein was considerably low in the CVD patients. 24587358 2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Presence of endothelial nitric oxide synthase (eNOS) gene polymorphism has been associated with cardiovascular disease (CVD) whereas exercise training (EX) promotes beneficial effects on CVD which is related to increased nitric oxide levels (NO). 21801125 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 Biomarker group BEFREE The eNOS modulatory role of statins may have an imperative influence on the functional regulation of cardiovascular system and may offer new perspectives for the better use of statins in ameliorating cardiovascular disorders. 21968328 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study. 22470539 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Taken together, our results show that the 27 nt repeat polymorphism of the intron 4 in the eNOS gene increases susceptibility to cardiovascular diseases after MeHg exposure by modulating nitric oxide levels. 22134029 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE A single nucleotide polymorphism in the eNOS gene, where thymine (T) replaces guanine (G) at position 894 predicting substitution of glutamate for aspartate at codon 298 (Glu298Asp), has been associated with increased CVD risk due to effects on nitric oxide synthesis and subsequently vascular reactivity. 22689471 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE We therefore assessed the association of glaucoma with polymorphisms of NOS3 and CYBA previously associated with cardiovascular disease. 22919264 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been associated with the pathogenesis of cardiovascular diseases, but few studies have evaluated the role of eNOS haplotypes on the risk and prognosis of heart failure (HF). 22290017 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 Biomarker group BEFREE Cell-based eNOS gene therapy has both proangiogenic and antiatherogenic effects and should be further investigated for the development of efficient therapeutic neovascularization designed to treat ischemic cardiovascular disease. 21224043 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Endothelial nitric oxide synthase (eNOS) gene variations have been linked to a higher risk for cardiovascular diseases (CVD) by unknown mechanisms. 20870316 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 AlteredExpression group BEFREE These data indicate that CAC dysfunction seen in high-risk patients can be partially reversed by eNOS overexpression, suggesting that ex vivo gene delivery may improve the efficacy of autologous cell therapy for cardiovascular disease. 21522135 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE A single nucleotide polymorphism G894T within exon 7 of endothelial nitric oxide synthase (eNOS-7) gene, resulting in a replacement of glutamic acid by aspartic acid, has been studied as a putative candidate gene for cardiovascular diseases. 21623032 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 AlteredExpression group BEFREE Thus, our findings revealed a critical function of Akt in mediating genistein-stimulated eNOS activity in PAECs, partially accounting for the beneficial effects of genistein on the development of cardiovascular diseases observed in animal models. 20926919 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Our findings suggest that eNOS gene polymorphisms (T-786C and Glu298Asp) are not associated with an increased risk for cardiovascular diseases in MeHg-exposed subjects. 21899406 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids. 20409549 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 Biomarker group CTD_human Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. 20610621 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Endothelial nitric oxide synthase gene polymorphisms, either independently or through gene environmental interactions, are associated with cardiovascular diseases in multiple ethnic populations. 20470943 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE Both the thymidine to cytosine transition mutation (T(-786)-->C) in the promoter region and the missense mutation in the exon 7 coding region of the eNOS gene (G(894)-->T) have been associated with several cardiovascular disease states. 20350698 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE However, the genetic background may also affect NO formation in the cardiovascular system, and recent studies have shown that genetic polymorphisms in the eNOS gene modify endogenous NO formation and the risk of developing cardiovascular diseases. 20210789 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation group BEFREE The endothelial nitric oxide (eNOS) gene T-786C polymorphism may influence as a genetic risk factor cardiovascular diseases and shows association with cardiovascular mortality. 20354497 2010